Evaluation of Renal Protective Activity of Adhatoda Zeylanica (Medic) Leaves Extract in Wistar Rats

Abstract

The kidney is especially a susceptible organ to toxic injuries by drugs and toxin, because of a high blood supply and the presence of cellular transport systems that cause accumulation of these compounds within the nephron epithelial cells. Glomerular, tubular and interstitial cells frequently encounter significant concentrations of medications and their metabolites, which can induce changes in kidney function and structure. Renal toxicity can be a result of hemodynamic changes, direct injury to cells and tissue, inflammatory tissue injury and/or obstruction of renal excretion.Gentamicin is potent broad spectrum antibiotic therapeutic agent used in a number of infective conditions. Because of the obvious mediation of Reactive Oxygen Species in Gentamicin induced renal damage. Several antioxidant agents have been used to block Gentamicin nephrotoxicity.There is a proven converse relationship between the consumption of antioxidant rich plants incidence of human diseases. A primary goal of this study is to present the scientific evidence for the use of common herb Adhatoda zeylanica as supplementary in the gentamicin treated acute renal failure (ARF) subjects. The beneficial effect of A. Zeylanica against gentamicin nephrotoxicity, possibly depends on its ability to scavenge the gentamicin induced free radicals.This study demonstrates the effectiveness of the extract improved with the polarity of the solvents over a period of 10 days and the plant has the potential to ameliorate Gentamicin nephrotoxicity.

Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

“…Kidneys have some fragile responsibilities, especially when they have to deal with unwanted substances, which they have to clear from the system, especially toxins. Kidney toxicity caused a rapid decline in renal functions that is mainly attributed to decrease in glomerular filtration rate (GFR) and lack of ability of the kidney to excrete these toxic metabolites produced in our body resulting in abnormal retention of renal biomarkers, i.e., blood urea nitrogen and creatinine (Kumar et al 2013). Also, increase in urea levels might indicate impairment in renal function (Cameron and Greger 1998).…”

Crocetin attenuating Urinary tract Infection and adherence of uropathogenic E. coli in NRK‐52E cells via an inflammatory pathway

“…The MIC of gentamicin has more than doubled from 1000 X to E. Coli , according to the current experimental work. Therefore, its indirect that gentamicin‐induced nephrotoxicity, especially to renal tubular epithelial cells, long treatment and use of large doses of antibiotics in the absence of xenobiotic metabolism (Kumar et al., 2013; McWilliam, 2015). Previously published research suggests that gentamicin‐induced apoptosis via the generation of reactive oxygen species (ROS) (De Almeida et al., 2020; Ma et al., 2018).…”

In vitro exposure of Adhatoda zeylanica to human renal cells lacks acute toxicity

“…Our study is the first to evaluate the in vitro nephrotoxicity of A. zeylanica with a specific focus on the proximal tubules. Although no other study has directly investigated its nephrotoxic potential, recent evidence by other researchers shows that A. zeylanica can help protect against the nephrotoxic effects of gentamycin in vivo [17] . Additionally, there are several publications describing the in vivo effects of A. zeylanica with respect to its reproductive toxicity in rodent models.…”