Evaluation of RELN gene polymorphism 
in children with autism spectrum disorder

Sahin, Nilufer; Kara, Murat; Kara, Bilge; Topal, Hatice

doi:10.5455/apd.292500

Cited by 1 publication

(3 citation statements)

References 20 publications

(24 reference statements)

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“…For our study, we selected the four genetic variants which had been more frequently analyzed in previous studies in order to be able to conduct a meta-analysis [20][21][22][23][24][31][32][33][34][35][36][37][38][39][40][41][42][43]. Due to the low sample sizes of previous studies and the low number of studies, it would be of interest to conduct more original gene candidate association studies (in addition to genome-wide association studies, such as the one recently developed by Matoba [16], but, unlike that paper, including healthy unrelated controls) to combine these studies with the meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the studies by Krebs et al [35] and Li et al [36] were excluded since they only considered cases and parents of cases but not healthy unrelated controls. Therefore, 11 studies [20,[22][23][24][37][38][39][40][41][42][43] were ultimately included in our meta-analysis. The allele and genotype distribution among the cases and controls is summarized in Tables 1-3.…”

Section: Study Identification and Selectionmentioning

confidence: 99%

“…The allele and genotype distribution among the cases and controls is summarized in Tables 1-3. Regarding the country of origin, three studies were carried out in China [24,39,43], two studies were performed in India [23,38], two studies were performed in Iran [40,41], and the other studies were performed in Canada [37], South Africa [22], Italy [20], and Turkey [42]. Other demographic characteristics are shown in Table 4.…”

Section: Study Identification and Selectionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Allelic Variants of the Reelin Gene with Autistic Spectrum Disorder: A Systematic Review and Meta-Analysis of Candidate Gene Association Studies

Hernández-García

Chamorro

Vega

et al. 2020

IJERPH

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Autistic spectrum disorder (ASD) is a complex neurodevelopmental disability with a genetic basis, and several studies have suggested a potential role of the reelin gene (RELN) in ASD susceptibility. Accordingly, genetic association studies have explored this potential association, but the results have been controversial thus far. For this reason, we assessed the association of four genetic variants of RELN (the 5′UTR CGG triplet repeat and polymorphisms rs736707, rs362691, and rs2229864) with ASD by means of a systematic review and meta-analysis. We retrieved studies comparing the distribution of the above-mentioned genetic variants between ASD patients and healthy controls. A meta-analysis was conducted using a random effects model, and calculations of the odds ratios (ORs) and confidence intervals (CIs) were performed. A sensitivity analysis and tests to determine the heterogeneity of the results were also performed. Eleven previous studies fulfilled the inclusion criteria and analyzed the association of the above-mentioned genetic variants and ASD. We did not find any significant association between the allele or genotype frequencies of the analyzed polymorphisms and ASD, and large heterogeneity was found for the rs736707 polymorphism. Moreover, no significant differences were found between the 5′UTR triplet repeat and this disorder. In light of current evidence, no single genetic variant within this gene is clearly associated with the development of ASD, and ethnic differences may explain part of the observed heterogeneity. Larger studies among different ethnic groups are needed to establish the role of specific genetic variants within RELN in the etiology of this disorder.

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