Evaluation of release retarding property of gum damar and gum copal in combination with hydroxypropyl methylcellulose

Fulbandhe, V M; C, Jobanputra; Wadher, Kamlesh; Umekar, Milind J.; Bhoyar, G S

doi:10.4103/0250-474x.106059

Cited by 12 publications

(8 citation statements)

References 16 publications

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“…Polyurethane can also be used for FDM 3D printing, in particular sustained-release tablets. Tablets loaded with theophylline and metformin were obtained by this method and showed sustained release [88]. Polylactide is a hydrophobic biodegradable polymer and is, therefore, used in research to produce vaginal rings and PLGA patches.…”

Section: Polymers For Additive Inkjet and 4d Printingmentioning

confidence: 99%

Polymers in Technologies of Additive and Inkjet Printing of Dosage Formulations

et al. 2022

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Technologies for obtaining dosage formulations (DF) for personalized therapy are currently being developed in the field of inkjet (2D) and 3D printing, which allows for the creation of DF using various methods, depending on the properties of pharmaceutical substances and the desired therapeutic effect. By combining these types of printing with smart polymers and special technological approaches, so-called 4D printed dosage formulations are obtained. This article discusses the main technological aspects and used excipients of a polymeric nature for obtaining 2D, 3D, 4D printed dosage formulations. Based on the literature data, the most widely used polymers, their properties, and application features are determined, and the technological characteristics of inkjet and additive 3D printing are shown. Conclusions are drawn about the key areas of development and the difficulties that arise in the search and implementation in the production of new materials and technologies for obtaining those dosage formulations.

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Section: Polymers For Additive Inkjet and 4d Printingmentioning

confidence: 99%

Polymers in Technologies of Additive and Inkjet Printing of Dosage Formulations

et al. 2022

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“…Drug retardation was directly proportional to the concentration of polymer, which may be due to the formation of strong compactness between the particles [32].…”

Section: In Vitro Buoyancy Studiesmentioning

confidence: 99%

“…4 and 5. Since, there are very few reports on the applicability of the selected natural gums as controlled release polymers, natural gum matrix tablets were prepared to evaluate their efficacy in controlling the drug release of clarithromycin [33][34][35][36][37]. Release retarding effect of concentration of gums on drug release was performed on batches containing neem (NG01-05), damar (DM01-05) and copal (CP01-05).…”

Section: In Vitro Dissolution Studies Of Clarithromycin Both Controllmentioning

confidence: 99%

Development, Formulation and Evaluation of a Bilayer Gastric Retentive Floating Tablets of Ranitidine HCL and Clarithromycin Using Natural Polymers

Rajeswari

Kudamala

Murthy

2017

Int J Pharm Pharm Sci

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Objective: Bilayer gastric retentive floating tablets (BGRFT) with ranitidine HCl and clarithromycin using natural gums have been developed to prolong the gastric residence time and increase drug bioavailability. Literature review revealed no published studies on the present study. Methods:Immediate release (IR) layer prepared by using different diluents and super disintegrants like sodium starch glycolate, crosscarmellose sodium and crospovidone. Controlled released (CR) layer prepared by using neem gum, damar gum and copal gum. Prepared tablets were evaluated for in vivo and in vitro buoyancy, in vitro dissolution studies and fourier transformation-infrared spectroscopy (FTIR). Drug release was evaluated with zero and first order for release kinetics, Higuchi, Hixson-Crowell erosion models for release mechanism.Results: Prepared IR layer followed first order rate kinetics and CR layer followed zero order rate kinetics with non-Fickian diffusion mechanism. BGRFT also showed similar results as that of the individual layer. Optimized formulations were characterized by FTIR studies and found no interactions between drug and polymer. Conclusion:The results demonstrate the feasibility of the model in the development of BGRFT. BGRFT enhanced the drug release and finally the bioavailability of clarithromycin when compared with commercial tablet (Biomycin 250). The present study could establish the suitability of neem gum as CR polymer in the design of BGRFT.

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“…2 Sustained or controlled drug delivery system is to reduce the frequency of dosing or to increase the effectiveness of drug by localization at the site of action, reducing dose required, providing continuous drug delivery, reduce incidence of adverse effect and maintain drug concentration in system. 1,3 Matrix tablets serve as an important tool for oral extended-release dosage forms. Hence, various problems like patient compliance, drug targeting, local side effects, frequent administration and fluctuations in blood concentration levels, associated with their counterparts, therefore the conventional dosage forms restricted.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 Both HPMC K4M and acacia gums are cellulose polymer based matrix which forms hydrogel due to simultaneous migration to the matrix. 3 Diclofenac sodium is 2-[2,6dichlorophenyl-amino] phenyl acetate and soluble in water. It is a Non-Steroidal Anti-Inflammatory Drug (NSAIDs) with analgesic activity.…”

Section: Introductionmentioning

confidence: 99%

Diclofenac Sodium Loaded Sustained Release Matrix Tablet Possessing Natural and Synthetic Polymers: Formulation and in vitro Characterization

Nagaich¹,

Bharti²,

Pal³

et al. 2014

IJPER

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Object:The objective of the present study was to investigate the effect of various concentrations of natural and synthetic polymers on in vitro drug release from sustained release matrix tablets. Materials and method: HPMC K4M and acacia gum were used as synthetic (hydrophilic) and natural (hydrophobic) polymers respectively. Diclofenac sodium was used as a model drug to study the in vitro release profile. Matrix tablets of Diclofenac sodium were fabricated by varying the concentrations of both natural and synthetic polymer via direct compression method. Result:The results of all evaluation parameters of the matrix tablet were within the acceptable limit. A significant difference was observed on in vitro drug release due to difference in polymers and their concentration. HPMC K4M in the concentration of 7% w/v showed 88.20 ± 0.056% cumulative drug release at the end of 10 h while the same concentration of acacia showed 85.22% ± 0.045%. The release mechanism of matrix tablet followed zero order release kinetics. The finding of current investigation clearly indicates that the synthetic polymer was given a more sustained release profile than natural polymer on varied concentration. Conclusion: On comparing in vitro release of optimized formulation with marketed preparation, it was concluded that F3 was found to be more efficient and promising than marketed preparation.

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Evaluation of release retarding property of gum damar and gum copal in combination with hydroxypropyl methylcellulose

Cited by 12 publications

References 16 publications

Polymers in Technologies of Additive and Inkjet Printing of Dosage Formulations

Polymers in Technologies of Additive and Inkjet Printing of Dosage Formulations

Development, Formulation and Evaluation of a Bilayer Gastric Retentive Floating Tablets of Ranitidine HCL and Clarithromycin Using Natural Polymers

Diclofenac Sodium Loaded Sustained Release Matrix Tablet Possessing Natural and Synthetic Polymers: Formulation and in vitro Characterization

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