Evaluation of relationship between inflammatory markers and hyperemesis gravidarum in patients admitted to emergency department

Can neutrophil‐to‐lymphocyte and monocyte‐to‐lymphocyte ratios be useful markers for predicting missed abortion in the first trimester of pregnancy?

“…39,40,50 Recently, NLR and MLR have been widely used as promising alternative diagnostic tools for systemic inflammatory response in various fields. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] In the present study, we detected the changes of the total or differential leukocyte counts, NLR and MLR between the MA cases and the normal pregnancy controls at 7 week's gestation. Except for the lymphocyte counts, the total or differential leukocyte counts, NLR and MLR in patients with MA were significantly lower than those in the normal controls (P < 0.05, respectively) ( Table 2).…”

“…Recent studies have reported that routine complete blood count (CBC) components, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) could be used as novel markers of systemic inflammatory response in various medical conditions, including pregnancy complications, [19][20][21][22][23][24][25][26][27][28][29] cancers, 30,31 cerebral hemorrhage, 32,33 ischemic stroke, [34][35][36] major cardiac events, 37,38 sepsis and infectious pathologies 39,40 and other diseases, in which these inexpensive and readily available inflammatory markers can help to stratify patient risks and individualize treatment strategy during everyday clinical practice. In particular, increasing evidence indicates that these inflammatory markers, such as NLR, MLR and neutrophil count, may be useful in predicting the risk of developing preeclampsia and invasion of gestational trophoblastic disease, and diagnosing HELLP syndrome, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, as well as hyperemesis gravidarum.…”

“…In particular, increasing evidence indicates that these inflammatory markers, such as NLR, MLR and neutrophil count, may be useful in predicting the risk of developing preeclampsia and invasion of gestational trophoblastic disease, and diagnosing HELLP syndrome, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, as well as hyperemesis gravidarum. [19][20][21][22][23][24][25][26][27][28][29] Recently, it was found that raised NLR in early second trimester of pregnancy as predictors for development and severity of preeclampsia. 21 Wang et al also reported that NLR and MLR have better diagnostic accuracy in distinguishing preeclampsia from controls, suggesting they are effective indicators of clinical assessment, disease severity evaluation, and prognosis evaluation of preeclampsia.…”

“…25 Kan et al reported that NLR, PLR and C-reactive protein (CRP) levels in patients with hyperemesis gravidarum (<16 weeks gestation) admitted to emergency department were significantly higher than those in normal controls. 29 In addition, MLR has been reported to be associated with increased risk of tuberculosis (TB) disease among human immunodeficiency virus (HIV)-Infected postpartum women. 41 To date, there are several studies on an association between these CBC indices and abortion.…”

Can Inflammatory Hematological Parameters be a Guide to Late-onset Fetal Growth Restriction?

“…Ratios that have been recently investigated in many diseases including the neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are affordable, sensitive, and useful inflammation markers [13]. Studies have indicated that these markers have prognostic value in coronary artery disease, diabetes, inflammatory arthritis, hyperemesis gravidarum, and preeclampsia [14,15]. They are also used for predicting mortality and morbidity in breast, ovarian, and gastric cancers [16].…”