Evaluation of red cell distribution width in dogs with pulmonary hypertension

Swann, James; Sudunagunta, Siddharth; Covey, Heather L.; English, Kate; Hendricks, Anke; Connolly, David

doi:10.1016/j.jvc.2014.08.003

Cited by 20 publications

(35 citation statements)

References 38 publications

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“…Most of the peer-reviewed veterinary medical literature regarding dogs with PH has evaluated the PDE5i, sildenafil. 40,42,43,52,80,84,[205][206][207] These studies suggest benefit with improvement of clinical signs, 52 quality of life, 52,84,207 exercise capacity, 84 Treatment strategies for PH are highly dependent on cause and chronicity of PH. Some PH-specific treatments (eg, pulmonary artery vasodilators such as PDE5i) might lead to acute pulmonary edema in some dogs with PH.…”

Section: Group 1 Pahmentioning

confidence: 99%

“…Most of the peer‐reviewed veterinary medical literature regarding dogs with PH has evaluated the PDE5i, sildenafil . These studies suggest benefit with improvement of clinical signs, quality of life, exercise capacity, and decreased echocardiographically‐estimated PAP compared with baseline, but TRV might not decrease after PDE5i treatment despite observed clinical benefits .…”

Section: Treatmentmentioning

confidence: 99%

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ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs

Reinero

Visser

Kellihan

et al. 2020

Veterinary Internal Medicne

184

383

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Pulmonary hypertension (PH), defined by increased pressure within the pulmonary vasculature, is a hemodynamic and pathophysiologic state present in a wide variety of cardiovascular, respiratory, and systemic diseases. The purpose of this consensus statement is to provide a multidisciplinary approach to guidelines for the diagnosis, classification, treatment, and monitoring of PH in dogs. Comprehensive evaluation including consideration of signalment, clinical signs, echocardiographic parameters, and results of other diagnostic tests supports the diagnosis of PH and allows identification of associated underlying conditions. Dogs with PH can be classified into the following 6 groups: group 1, pulmonary arterial hypertension; group 2, left heart disease; group 3, respiratory disease/hypoxia; group 4, pulmonary emboli/pulmonary thrombi/pulmonary thromboemboli; group 5, parasitic disease (Dirofilaria and Angiostrongylus); and group 6, disorders that are multifactorial or with unclear mechanisms. The approach to treatment of PH focuses on strategies to decrease the risk of progression, complications, or both, recommendations to target underlying diseases or factors contributing to PH, and PH‐specific treatments. Dogs with PH should be monitored for improvement, static condition, or progression, and any identified underlying disorder should be addressed and monitored simultaneously.

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Section: Group 1 Pahmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs

Reinero

Visser

Kellihan

et al. 2020

Veterinary Internal Medicne

184

383

View full text Add to dashboard Cite

show abstract

“…No correlation between RDW and MCV was noted by Mazzotta et al (2016), in contrast to the previous studies by other authors (Fig. 2), both in humans and dogs (Hampole et al 2009;Guglielmini et al 2013;Swann et al 2014). Reasons for this divergence remain unclear.…”

Section: Discussionmentioning

confidence: 54%

Evaluation of frequency and intensity of asymptomatic anisocytosis in the Japanese dog breeds Shiba, Akita, and Hokkaido

et al. 2017

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Microcytosis is observed in healthy Japanese breed dogs. The aim of the study was to evaluate the frequency and intensity of asymptomatic anisocytosis using a three-grade scale in Japanese dog breeds with special emphasis on the following indices: mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, and red blood cell distribution width. The retrospective study included analyses of blood morphology and blood smear for clinically healthy Japanese dog breeds Shiba, Akita, and Hokkaido aged from 6 months to 14 years, performed as a part of preventative care. A total of 74 dogs of both sexes were qualified for the study. The group included both neutered and non-neutered animals (Akita -17 females, 12 males, Shiba -24 females, 18 males, Hokkaido -2 females, 1 male). The blood smear revealed significant anisocytosis in 60.8% and mild anisocytosis in 28.4% of the tested dogs -89.2% in total. Microcytosis was reported for 25.7% of the tested Japanese breed dogs. Reduced mean cell haemoglobin and mean cell haemoglobin concentration were diagnosed in 75.7% and 40.5% of dogs, respectively. Red blood cell distribution width as an anisocytosis indicator exceeded the norm in 12% of the tested dogs. Compared to mixed breed dogs, the Japanese breeds had a reduced mean cell volume, mean cell haemoglobin concentration and significant anisocytosis in the blood smear as well as a higher red blood cell distribution width indicator. Veterinarians should consider these differences when interpreting the results of morphological blood tests.

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“…It demonstrated that RDW is highly different among dogs suffering from pre-capillary PH and controls; however, no significant differences were found between patients showing post-capillary PH and controls. There was a similar proportion of survival rate among dogs gathered depending on RDW values, but RDW did not properly predict PH seriousness ( 30 ).…”

Section: Traditional Laboratory Testmentioning

confidence: 99%