Evaluation of Red Blood Cell Transfusion Practice and Knowledge Among Cancer Surgeons

Beal, Eliza W.; Tsung, Allan; McAlearney, Ann Scheck; Gregory, Megan E.; Nyein, Kyi Phyu; Scrape, Scott; Pawlik, Timothy M.

doi:10.1007/s11605-020-04899-7

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Cancerous anemia will not only reduce the quality of life of patients but also reduce the therapeutic effect of cancer, thus indirectly reducing the survival rate of patients. Cancerous anemia may be one of the independent prognostic factors affecting the survival of cancer patients, so it is necessary for cancer patients to receive blood transfusion [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Hemoglobin is an important oxygen-carrying tool in the human body. 1.5% to 2.0% of the oxygen in the blood exists in a physical state, and most of the oxygen binds to hemoglobin, and the decrease in the concentration of hemoglobin in the blood leads to tissue hypoxia, which further increases the percentage of hypoxic cells in tumor tissue [ 2 , 3 ]. The killing effect of tumor radiotherapy depends to a large extent on the oxygen content of tumor cells, which can be said to be the strongest radiosensitizer [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hematocrit Injury on the Survival Rate of Advanced Malignant Tumors and Its Clinical Significance

Li¹,

Wu²,

Yin

2022

Computational and Mathematical Methods in Medicine

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Objective. To investigate the effect of logistic multivariate analysis on the survival rate of advanced malignant tumors and to evaluate the effect of erythrocyte storage injury on the survival rate of advanced malignant tumors and its clinical significance. Methods. A retrospective analysis was performed on 120 advanced cancer patients who received blood transfusion in Shaanxi Cancer Hospital from March 2018 to June 2019, and the risk factors for death were analyzed. A total of 72 advanced cancer patients admitted to hospital from March 2019 to June 2021 were included in the study. The patients with red blood cell transfusion storage time ≤ 14 d were the study group ( n = 36 ), and the patients with red blood cell transfusion storage time > 14 d were the control group ( n = 36 ). Compare the total efficiency of blood transfusion. The levels of Hb, erythrocyte count, hematocrit (HCT), blood oxygen saturation (SPO2), creatinine (Cr), erythrocyte deformability index, whole blood, erythrocyte, and hemoglobin before and after blood transfusion were compared, and the adverse reactions of blood transfusion were recorded. Results. Dyspnea and delirium were significantly associated with patient survival time ( P < 0.05 ). Red blood cell storage time ≤ 14 days, Lym % < 12 % , lactate dehydrogenase LDH > 500 U/L, and ALB < 30 g/L were significantly correlated with survival time. Karnofsky performance status KPS < 30 , delirium, LDH > 500 U/L, and albumin ALB < 30 g/L were independent influencing factors of survival ( P < 0.05 ). The overall effective rate of the research group was higher ( P < 0.05 ). The incidence of adverse reactions in the study group was lower ( P < 0.05 ). The levels of Hb, red blood cell count, and HCT in the study group were higher ( P < 0.05 ). Compared with the control group, the SPO2 level and the red blood cell deformability index were higher in the study group ( P < 0.05 ). After blood transfusion, the level of (diphosphoglycerate) DPG in the study group was higher than that in the control group ( P < 0.05 ). The length of hospital stay in the study group was significantly shortened ( P < 0.05 ). The nosocomial infection rate and case fatality rate in the study group were significantly reduced ( P < 0.05 ). Conclusion. Red blood cell storage time ≤ 14 d, LYM % < 12 % , LDH > 500 U/L, and ALB < 30 g/L are all significantly correlated with survival time. KPS < 30 , delirium, LDH > 500 U/L, and ALB < 30 g/L were independent factors for survival ( P < 0.05 ). Transfusion of red blood cells stored for ≤14 days in patients with advanced malignant tumors can significantly increase the effective infusion rate, improve anemia status, shorten hospital stay, and reduce mortality and risk of nosocomial infection and is worthy of clinical promotion.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Hematocrit Injury on the Survival Rate of Advanced Malignant Tumors and Its Clinical Significance

Li¹,

Wu²,

Yin

2022

Computational and Mathematical Methods in Medicine

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“…O conhecimento dos cirurgiões oncológicos em medicina transfusional varia amplamente, no que tange a investigação de anemia pré-operatória, solicitações, uso de alternativas ao uso de concentrado de hemácias e consequências negativas da transfusão. Dessa forma, é imprescindível uma educação adicional em relação a prática e gatilhos apropriados para a transfusão, os programas de Patient Blood Management (PBM) são grandes aliados nesse processo e podem incentivar o aprimoramento das condutas (Beal et al, 2021). O PBM trata-se de uma abordagem sistemática, centrada no paciente e baseada em evidências para melhorar os resultados, ao manejar e preservar o próprio sangue do paciente, ao mesmo tempo em que promove a segurança e o empoderamento do mesmo (Shander et al, 2022).…”

Section: Introductionunclassified

Análise das reservas cirúrgicas de concentrados de hemácias em um hospital oncológico

Siqueira¹,

Neto

Santos³

et al. 2022

RSD

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O sangue possui um papel fundamental da manutenção da sobrevida de pacientes durante a realização de procedimentos cirúrgicos eletivos. A transfusão de concentrados de hemácias é capaz de corrigir rapidamente o estado anêmico e melhorar a oxigenação, no entanto, sua realização está associada a desfechos adversos. Em pacientes oncológicos está ligada a pior sobrevida e maior risco de recidiva. Dessa forma, buscou-se analisar as reservas de concentrado de hemácias e avaliar o perfil dos pacientes submetidos as cirurgias eletivas, em um hospital oncológico. Foi um estudo do tipo observacional, descritivo com delineamento transversal, com análise de todas as fichas de solicitações de concentrado de hemácias para reserva cirúrgica, com uma amostra de 1386 solicitações. As mulheres e a faixa etária entre 40 e 79 anos foram o público mais transfundido com concentrados de hemácias, as cirurgias eram de grande porte, os setores responsáveis pela maior número de transfusão foram cirurgia oncoabdominal e oncoginecologia, assim como as patologias desses setores câncer de estômago e câncer do colo do útero; procedimentos com excesso de compatibilização foram tratamento cirúrgico para epilepsia, traquelectomia, arteriografia e esplenectomia; a maioria dos procedimentos apresentou um índice de pacientes transfundidos > 10% para os quais é necessário a reserva do hemocomponente, já na análise do Maximal Blood Order Schedule, notou-se que uma ampla gama de procedimentos necessita de duas unidades de concentrados de hemácias. Isso gerou subsídios para estimular o uso racional do sangue na instituição de saúde.

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Goal-Directed Therapy in Liver Surgery

Marcus,

Syed,

Anderson

et al. 2024

Curr Anesthesiol Rep

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Purpose of Review This review summarizes the updated literature on goal-directed therapy during liver surgery. It provides guidance for clinicians regarding physiologic concepts and clinical evidence related to fluid and hemodynamic management strategies during and after liver resection. Recent Findings Open liver resection presents unique anatomic and physiologic challenges for the anesthesiologist. Care must be taken to reduce hemorrhage via control of inflow and outflow of hepatic blood. Resuscitation should be individualized to the patient and primarily utilize balanced crystalloids, blood products, and possibly albumin. Administration of intravenous fluids should be guided by hemodynamic parameters. Minimally invasive liver resection may be beneficial to patients but presents additional considerations for goal-directed therapy. Summary Goal-directed therapy can be utilized to decrease blood loss and optimize the surgical field during liver resection. This strategy holds promise to improve patient outcomes after liver surgery.

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Evaluation of Red Blood Cell Transfusion Practice and Knowledge Among Cancer Surgeons

Cited by 5 publications

References 33 publications

Effect of Hematocrit Injury on the Survival Rate of Advanced Malignant Tumors and Its Clinical Significance

Effect of Hematocrit Injury on the Survival Rate of Advanced Malignant Tumors and Its Clinical Significance

Análise das reservas cirúrgicas de concentrados de hemácias em um hospital oncológico

Goal-Directed Therapy in Liver Surgery

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