Evaluation of Red Blood Cell Distribution Width in Patients with Cardiac Syndrome X

Abstract

Abstract. BACKGROUND: Cardiac syndrome X (CSX) is a condition characterized by chest pain with normal coronary arteries. However, its pathogenesis has not fully been understood yet. Red blood cell distribution width (RDW) has recently been suggested as a marker of acute and chronic cardiovascular diseases, while no data is available in patients with CSX. METHODS: One hundred and twenty consecutive patients with CSX and 102 normal controls were prospectively enrolled in this study. Blood samples were drawn from all individuals for measuring RDW and high-sensitivity C-reactive protein (CRP). The baseline data were compared between patients with CSX and normal controls. RESULTS: The RDW levels were significantly higher in patients with CSX than that in those with normal controls (13.1 ± 2.1 versus 12.3 ± 1.8, p = 0.011). Moreover, the data showed that the levels of plasma CRP were marked higher in patients with CSX than those that were observed in normal controls (CRP: 2.8 ± 2.2 mg/L versus 2.0 ± 1.7 mg/dl, p = 0.014). In addition, the multivariate analysis indicated that peripheral monocyte cell, CRP and RDW were the independent variables most strongly associated with CSX. In a receiver operating characteristic (ROC) curve analysis, we found that an RDW value of 12.8% was used as an effective cut-point in the segregation of the presence or absence of cardiac syndrome X, a sensitivity of 52.0% and a specificity of 65.4% were obtained. Finally, correlation analysis suggested that there was positive correlation between plasma levels of CRP and RDW levels (n = 120, γ = 0.381, P = 0.013). CONCLUSIONS: The present study, for the first time, demonstrated that elevated RDW and CRP levels were independently associated with the presence of CSX.

Red Cell Distribution Width Is Associated with Presence, Stage, and Grade in Patients with Renal Cell Carcinoma

“…A retrospective analysis was conducted in patients with primary diagnosed, pathologically confirmed, and sporadic RCC and controls identified hospital patients with simple renal cyst, between January 2010 and June 2013 at Department of Urology at Peking University Third Hospital. The exclusion criteria of the study were the presence of medical history of other malignancy, pregnancy, kidney transplantation, hematological disorders, severe anemia, infectious or inflammatory disease, iron supplementation therapy, recent venous thrombosis (past 6 months), recent blood transfusion (past 3 months), chronic obstructive pulmonary disease, hepatitis B or C, heart failure, arrhythmia, untreated thyroid disease, and severe liver and/or renal insufficiency as described previously [ 26 ]. All data on age, gender, body mass index (BMI), history of hypertension or diabetes, smoking, blood parameters, histology, stage at diagnosis (2009 AJCC TNM classification), and Fuhrman grading were obtained from electronic records and medical charts.…”

The usefulness of plateletcrit to predict cardiac syndrome X in patients with normal coronary angiogram

“…In a study in patients with cardiac syndrome X, CRP level was found to be correlated with the activity of the disease [ 14 ]. In a similar vein, elevated red cell distribution width (RDW) levels were found to be independently associated with presence of CSX, and in the same study RDW and CRP levels were reported to correlate positively [ 15 ]. In another study, the presence of endothelial dysfunction and sub-angiographic atheroma was revealed in patients with CSX [ 16 ].…”

Eritrosit Dağılım Genişliği (RDW): Metastatik Kolorektal Kanserde Prognoz Belirleyici Olarak Kullanımı

“…Çalışmaya Mersin Üniversitesi Tıbbi Onkoloji Kliniği'ne başvuran, dosyasına ulaşılabilen tüm metastatik kolorektal kanserli hastalar alındı. Çalışmanın dışlama kriterleri; başka bir malignite öyküsü olması, gebelik, böbrek nakli, hematolojik hastalıklar, ciddi anemi, enfeksiyon veya inflamatuar hastalıklar, demir eksikliği tedavisi, yeni venöz tromboz (son 6 ayda), yeni kan transfüzyonu (son 3 ayda), kronik obstrüktif akciğer hastalığı, hepatit b veya c, kalp yetmezliği, aritmi, tedavi edilmemiş tiroid hastalığı ve bilinen ciddi karaciğer ve/veya böbrek hastalığı olması (17) . İnflamasyonun, solid tümörlerin progresyonunda rol oynadığı gösterilmiştir, ancak agresif hastalığın artmış inflamasyona neden olup olmadığı veya inflamasyonun agresif hastalıktan kaynaklanıp kaynaklanmadığı belirsizdir.…”