Evaluation of recurrent high‐grade gliomas treated with bevacizumab: A preliminary report of 3D pseudocontinuous artery spin labeling

Lyu, Yuelei; Liu, Shuai; You, Hui; Hou, Bo; Wang, Yu; Ma, Wenbin; Feng, Feng

doi:10.1002/jmri.25558

Cited by 5 publications

(4 citation statements)

References 32 publications

(108 reference statements)

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“…Relevant articles were selected according to PRISMA (see relevant flow chart in Figure 1). 104 of them were excluded as they did not met the research question; for example: they applied ASL in animal models [13] use ASL in order to asses the treatment [14, 15] or applied in pediatric population [16]. Eventually, 18 studies were deemed eligible in terms of the selected inclusion criteria.…”

Section: Methodsmentioning

confidence: 99%

The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis

et al. 2019

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This study aimed to evaluate the diagnostic performance of arterial spin labelling (ASL) in grading of adult gliomas. Eighteen studies matched the inclusion criteria and were included after systematic searches through EMBASE and MEDLINE databases. The quality of the included studies was assessed utilizing Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The quantitative values were extracted and a meta-analysis was subsequently based on a random-effect model with forest plot and joint sensitivity and specificity modelling. Hierarchical summary receiver operating characteristic (HROC) curve analysis was also conducted. The absolute tumour blood flow (TBF) values can differentiate high-grade gliomas (HGGs) from low-grade gliomas (LGGs) and grade II from grade IV tumours. However, it lacked the capacity to differentiate grade II from grade III tumours and grade III from grade IV tumours. In contrast, the relative TBF (rTBF) is effective in differentiating HGG from LGG and in glioma grading. The maximum rTBF (rTBFmax) demonstrated the best results in glioma grading. These results were also reflected in the sensitivity/specificity analysis in which the rTBFmax showed the highest discrimination performance in glioma grading. The estimated effect size for the rTBF was approximately similar between HGGs and LGGs, and grade II and grade III tumours, (–1.46 (–2.00, –0.91), p-value < 0.001), (–1.39 (–1.89, –0.89), p-value < 0.001), respectively; while it exhibited smaller effect size between grade III and grade IV (–1.05 (–1.82, –0.27)), p < 0.05). Sensitivity and specificity analysis replicate these results as well. This meta-analysis suggests that ASL is useful for glioma grading, especially when considering the rTBFmax parameter.

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Section: Methodsmentioning

confidence: 99%

The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis

et al. 2019

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“…Other studies have assessed the detection of residual tumor shortly after surgery. 84 ASL has shown success at predicting and monitoring response to bevacizumab, 85 , 86 an anti-angiogenic agent. ASL has also shown value in differentiating pseudoprogression from recurrence.…”

Section: Practical Acquisition and Post-processingmentioning

confidence: 99%

Arterial Spin Labeling: Key Concepts and Progress Towards Use as a Clinical Tool

Jaafar,

Alsop

2024

magn reson med sci

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“…The authors measured CBF before and after treatment in 16 patients with recurrent high-grade glioma receiving bevacizumab-combined chemotherapy and determined that both rCBF with the cerebellar CBF as the reference before treatment and the average magnitude of the change in CBV (aCBF) before and after treatment were significantly associated with OS and PFS. The study suggested that the FSE pcASL technique might be useful for generating predictive images ( Lyu et al, 2017 ).…”

Section: Physiological Parameters In Anti-angiogenic Therapymentioning

confidence: 99%

Imaging biomarkers guided anti-angiogenic therapy for malignant gliomas

Kong

Yan

Zhu

et al. 2018

NeuroImage: Clinical

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Antiangiogenic therapy is a universal approach to the treatment of malignant gliomas but fails to prolong the overall survival of newly diagnosed or recurrent glioblastoma patients. Imaging biomarkers are quantitative imaging parameters capable of objectively describing biological processes, pathological changes and treatment responses in some situations and have been utilized for outcome predictions of malignant gliomas in anti-angiogenic therapy. Advanced magnetic resonance imaging techniques (including perfusion-weighted imaging and diffusion-weighted imaging), positron emission computed tomography and magnetic resonance spectroscopy are imaging techniques that can be used to acquire imaging biomarkers, including the relative cerebral blood volume (rCBV), Ktrans, and the apparent diffusion coefficient (ADC). Imaging indicators for a better prognosis when treating malignant gliomas with antiangiogenic therapy include the following: a lower pre- or post-treatment rCBV, less change in rCBV during treatment, a lower pre-treatment Ktrans, a higher vascular normalization index during treatment, less change in arterio-venous overlap during treatment, lower pre-treatment ADC values for the lower peak, smaller ADC volume changes during treatment, and metabolic changes in glucose and phenylalanine. The investigation and utilization of these imaging markers may confront challenges, but may also promote further development of anti-angiogenic therapy. Despite considerable evidence, future prospective studies are critically needed to consolidate the current data and identify novel biomarkers.

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Evaluation of recurrent high‐grade gliomas treated with bevacizumab: A preliminary report of 3D pseudocontinuous artery spin labeling

Abstract: 3 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:565-573.

Cited by 5 publications

References 32 publications

The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis

The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis

Arterial Spin Labeling: Key Concepts and Progress Towards Use as a Clinical Tool

Imaging biomarkers guided anti-angiogenic therapy for malignant gliomas

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