Evaluation of Recurrent Glomerulonephritis in Kidney Allografts

Recurrence of Type I Membranoproliferative Glomerulonephritis After Renal Transplantation

“…In our study, th e graft survival of patients w ith recurrence was poor and comparable to the outcome reported in other single-center studies. Morzycka et al (18) observed graft loss in five of six patients w ith recurrence, O'M eara et al (3) observed it in four of eight, V angelista et al (7) observed it in two of the four patients, and in the series by Berthoux et al (13) all four patients w ith recurrence lost th e ir allograft.…”

“…To our knowledge, this is the first report of a series of patients who received a second transplantation after having lost their first graft due to recurrent type I MPGN, There have, however, been descriptions in the literature of several patients with a recurrence in two successive trans plants (13,18,(22)(23)(24)(25). These data strengthen our findings th a t patients with a recurrence in their first graft have a high risk of a second recurrence.…”

“…It is known th at patients with IgA nephrop athy have a higher risk of recurrent disease when receiving a kidney from a living related donor (19)(20)(21). This information is not available for patients with type I MPGN, although two studies suggest th a t all forms of glomerulonephritis are more likely to occur in recipients of a living related donor graft (3,18).…”

Renal Allograft Survival in Transplant Recipients with Focal Segmental Glomerulosclerosis

“…Surveying 89 U.S. transplant centers in the late 1970s, Zimmerman reported an 82% incidence of recurrent FSGS in transplant recipients who received at least a 4-antigen-matched LRD transplant, and concluded that HLA-identical sibling transplants should be avoided in this population (8). Subsequently, Morzycka et al suggested that recurrent FSGS was more common in those renal transplant recipients who received LRD transplants (9). Current reference literature on renal transplantation continues to suggest that LRD transplants for patients with FSGS have a high rate of recurrence and hence, portend a worse outcome with such transplants as opposed to cadaveric transplants (10,11).…”

The Evaluation of the Renal Transplant Candidates: Clinical Practice Guidelines

“…The incidence of histologic recurrence has been shown to increase with duration of follow-up after transplantation (308). Clinical recurrence (variously defined) has been reported in most studies to be 20-40% (273,275,278,283,300,(308)(309)(310)(311)(312)(313)(314)(315). However, in the largest series (nΩ104, median follow-up of 5 years) clinical recurrence occurred in only 12.5% (315).…”