Evaluation of real-world mobility in age-related macular degeneration

Sengupta, Sabyasachi; Nguyen, Angeline; Landingham, Suzanne W. van; Solomon, Sharon D.; Diana, V.; Ferrucci, Luigi; Friedman, David S.; Ramulu, Pradeep Y.

doi:10.1186/1471-2415-15-9

Cited by 39 publications

(43 citation statements)

References 36 publications

(42 reference statements)

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“…*Unilateral any AMD progression to bilateral any AMD.†Unilateral late AMD progression to bilateral late AMD.‡p Trend calculated using Mantel-Haenszel χ2 test for linear association.§Combined risk dichotomised as 0 or 1 risk allele of CFH or ARMS2 or 2 to 4 risk alleles of CFH and/or ARMS2. …”

Section: Resultsmentioning

confidence: 99%

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Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report

et al. 2017

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Purpose To assess the 5-year progression from unilateral to bilateral age-related macular degeneration (AMD) and associated risk factors. Design Pooled data analyses of three prospective population-based cohorts, the Blue Mountains Eye Study, Beaver Dam Eye Study and Rotterdam Study. Methods Retinal photography and interview with comprehensive questionnaires were conducted at each visit of three studies. AMD was assessed following the modified Wisconsin AMD grading protocol. Progression to bilateral any (early and late) or late AMD was assessed among participants with unilateral involvement only. Factors associated with the progression were assessed using logistic regression models while simultaneously adjusting for other significant risk factors. Results In any 5-year duration, 19–28% of unilateral any AMD cases became bilateral and 27–68% of unilateral late AMD became bilateral. Factors associated with the progression to bilateral involvement of any AMD were age (per year increase, adjusted OR 1.07), carrying risk alleles of the complement factor H and age-related maculopathy susceptibility 2 genes (compared with none, OR 1.76 for 1 risk allele and OR 3.34 for 2+ risk alleles), smoking (compared with non-smokers, OR 1.64 for past and OR 1.67 for current smokers), and the presence of large drusen area or retinal pigmentary abnormalities in the first eye. Conclusion One in four to one in five unilateral any AMD cases, and up to one in two unilateral late AMD cases, progressed to bilateral in 5 years. Known AMD risk factors, including smoking, are significantly associated with the progression to bilateral involvement.

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Section: Resultsmentioning

confidence: 99%

“…While the presence of AMD in one eye can be debilitating, vision loss and blindness in both eyes due to bilateral AMD will have severe consequences for the affected individuals 2 3…”

Section: Introductionmentioning

confidence: 99%

Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report

et al. 2017

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“…Patients with AMD have decreased mobility, spend less time in moderate-to-robust physical activity, and are less likely to spend time out of home. 11 Depression and mood disorders are a significant problem in elderly patients affected by AMD. 12 Recent advances in management, such as anti-VEGF agents, have improved the outlook for patients with wet AMD.…”

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confidence: 99%

Prognosis and Treatment of Visual Field Defects

Agarwal

Kedar

2015

Semin Neurol

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Visual field deficits are common in neurologic disease conditions such as cerebrovascular disease, traumatic brain injury, and brain tumors. Loss of visual fields may lead to impairment of reading skills (hemianopic dyslexia) and limitations of daily activities such as driving, which can have a significant impact on an individual's socioeconomic status and quality of life. Moreover, patients with motor deficits from neurologic diseases have a 20% decreased likelihood of achieving independence in ambulation and self-care activities with coexisting hemianopia. Studies on the natural history of homonymous hemianopia have shown that spontaneous improvement of visual fields may occur in less than 40% of individuals early in the disease process. Improvement is usually incomplete, which implies that a significant number of individuals will be left with a disabling visual deficit. Although several methods of rehabilitation (optical, compensatory, and restitution therapy) are used in practice, none, unfortunately, have shown consistent and significant benefits. In this review, the authors focus on the natural history, impact, prognosis, and treatment modalities for neurologic field defects.

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“…http://bjo.bmj.com/ Br J Ophthalmol: first published as 10.1136/bjophthalmol-2019-313864 on 9 July 2019. Downloaded from vision to be binocular visual field, followed by scanning ability, low-contrast VA and finally, high-contrast VA; while another 28 reported reduced VA and CS to predict mobility restriction in AMD.…”

Section: Discussionmentioning

confidence: 99%

Measuring dynamic levels of self-perceived anxiety and concern during simulated mobility tasks in people with non-neovascular age-related macular degeneration

et al. 2019

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Background/aimsTo assess response to real-world mobility scenarios in people with dry age-related macular degeneration (AMD) using a computer-based test.MethodsParticipants were shown 18 point-of-view computer-based movies simulating walking through real-world scenarios, and pressed a button during scenes which would cause them self-perceived anxiety or concern in their day-to-day life. Button pressure was recorded throughout. Pressure traces were generated, which aligned with each movie time point. Group averages based on AMD severity were generated. Bootstrapped confidence intervals (CIs) for responses by group were generated around traces. Traces were examined to discover events causing the greatest differences between groups.ResultsParticipants had early/no AMD (n=8), intermediate AMD (n=7) or geographic atrophy (n=15 (GA)). Median (IQR) logMAR visual acuity was 0.04 (−0.04, 0.18), 0.26 (0.10, 0.40) and 0.32 (0.20, 0.56), respectively. Participants with intermediate AMD or GA recorded greater pressure than those with early and no AMD (Kruskal-Wallis, p=0.04). Four events involving navigating stairs and three under low luminance elicited greatest differences between groups (p<0.001).ConclusionPeople with intermediate AMD or GA likely experience higher levels of concern associated with mobility. The test highlights areas of specific concern. Results should be useful in patient management and educating the public about the everyday effects of AMD.

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Evaluation of real-world mobility in age-related macular degeneration

Cited by 39 publications

References 36 publications

Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report

Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report

Prognosis and Treatment of Visual Field Defects

Measuring dynamic levels of self-perceived anxiety and concern during simulated mobility tasks in people with non-neovascular age-related macular degeneration

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