Evaluation of rat plasma proteins after bothropic venom inoculation and treatment with Mesenquimal stem cells

Telles, Thalita Costa; Michel, Ana Flávia Ribeiro Machado; Lucia, Maria Della; Melo, Bruno Martins; Costa-Val, Adriane Pimenta da; Ocarino, Natália de Melo; Melo, Marília Martins

doi:10.1590/s1516-89132014000100005

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Albumin is an acute negative phase protein common to inflammatory process (Silva et al, 2005). Albumin synthesis is altered by a variety of stress factors, including bothropic envenomation, causing total protein reduction (Telles et al, 2014).…”

Section: Biochemicalmentioning

confidence: 99%

Use of EDTA in the treatment of local tissue damage caused by the Bothrops alternatus venom

Silva-Neto

Santos

Botelho

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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Twelve adult rabbits were distributed in three groups and received on the femoral biceps region, via intradermal injection (ID), 25µg of Bothrops alternatus venom dissolved in NaCl 0.9% and diluted in 0.25mL of phosphate buffered saline (PBS). Thirty minutes later, the group G1 received 0.25mL of phosphate buffered saline (PBS) ID while to G2 and G3 25mg of ethylenediamine tetraacetic acid (EDTA) dissolved in 0.25mL of PBS were administered via intramuscular (IM) and intravenous (IV) injection, respectively. Evaluations included local lesion and blood profile of all animals, before (time zero) and at 1, 2, 3, 4, 5, 6, 12, 18 and 24h after venom administration. All animal treated with PBS (G1) and EDTA IV (G3) presented increase of nociceptive stimuli at the site of inoculation of the venom, followed by moderate edema that persisted for 24h. Animals treated with IM EDTA (G2) only manifested increase of nociceptive stimuli at the site of injection 1h after treatment with discrete local edema between 12 and 24h. In relation to the local hemorrhagic halo no differences were found amongst the studied groups. Blood profile revealed significant decrease of segmented neutrophils in all groups. There was also increase in triglycerides and decrease in total protein and albumin in all groups. The local lesion was not altered by the treatments.

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Section: Biochemicalmentioning

confidence: 99%

Use of EDTA in the treatment of local tissue damage caused by the Bothrops alternatus venom

Silva-Neto

Santos

Botelho

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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Effect of gamma-irradiated honey bee venom on blood parameter and histopathological observations of liver and kidney in a mice animal model

Abbasi,

Shawrang,

Sadeghi

et al. 2023

Research in Veterinary Science

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Evaluation of rat plasma proteins after bothropic venom inoculation and treatment with Mesenquimal stem cells

Abstract: The aim of this work was to evaluate the mesenchymal stem cells treatment of rats with myonecrosis caused by

Cited by 2 publications

References 22 publications

Use of EDTA in the treatment of local tissue damage caused by the Bothrops alternatus venom

Use of EDTA in the treatment of local tissue damage caused by the Bothrops alternatus venom

Effect of gamma-irradiated honey bee venom on blood parameter and histopathological observations of liver and kidney in a mice animal model

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