Evaluation of radiotherapy in high-risk breast cancer patients: Report from the Danish Breast Cancer Cooperative Group (DBCG 82) trial

Overgaard, Marie; Christensen, Jane; Johansen, H; Nybo-Rasmussen, A.; Rose, Carsten; Kooy, P. van der; Panduro, J.; Laursen, Finn; Kjær, Mogens; Sørensen, Nina; Gadeberg, C.; Hjelm-Hansen, M.; Overgaard, Jens; Andersen, Knud West; Zedeler, Karin

doi:10.1016/0360-3016(90)90214-5

Cited by 116 publications

(24 citation statements)

References 11 publications

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“…Secondly, the more limited dissection also increased LRR risk by failing to remove microscopic axillary disease. Indeed, in the patients who did not receive radiation, 45% of all LRR in the Danish study occurred in the axilla [14]. This percentage is significantly higher than the contributions of axillary recurrences to total LRR reported in other series that had standard axillary dissections [15,16].…”

Section: Mastectomy and Adjuvant Chemotherapycontrasting

confidence: 44%

Controversies Regarding the Use of Radiation After Mastectomy in Breast Cancer

et al. 2002

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Despite years of clinical study, there are still many unanswered questions regarding postmastectomy radiation. It is clear that radiation therapy plays a critical role in the multidisciplinary management of patients with locally advanced or inflammatory breast cancer. It is also accepted that postmastectomy radiation is not required for most women with noninvasive disease or stage I disease. Randomized clinical trials studying radiation treatments for women with stage II or III breast cancer have shown that the addition of radiation after mastectomy can reduce local-regional recurrence rates, which then improves survival. However, other data have indicated that the risk of local-regional recurrence after mastectomy and chemotherapy is low for patients with small tumors and one to three positive lymph nodes, leading some to question whether postmastectomy radiation is useful for this group. A second controversy regards the sequencing of postmastectomy radiation and breast reconstruction. In this article we discuss these controversies, review the data that are relevant, and provide our institutional approaches to these issues.

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Section: Mastectomy and Adjuvant Chemotherapycontrasting

confidence: 44%

Controversies Regarding the Use of Radiation After Mastectomy in Breast Cancer

et al. 2002

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“…On the other hand, many patients may benefit from the freedom from local recurrence that may be achieved by radiotherapy. Recent analyses of some randomised trials indicate that the addition of radiotherapy increases the survival for subgroups of patients (5).…”

mentioning

confidence: 99%

Late Effects of Radiotherapy in the Treatment of Breast Cancer

Wallgren¹

1992

Acta Oncologica

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“…Three recently published randomized trials (the British Columbia study, the EBCTCG 2005, and a subgroup analysis of the DBCG 82b&c trials investigating subgroups of breast cancer patients with ≤ 3 pN+ and postoperative RT) demonstrated that RT could improve OS [4,[17][18][19]23]. This survival advantage was also found in "the combined dataset" analysis of the EORTC [34].…”

Section: Discussionmentioning

confidence: 77%