Evaluation of Radiography and Isotopic Scintigraphy for Detecting Skeletal Metastases in Breast Cancer

Roberts, John G.; Gravelle, I. H.; Baum, Michael; Bligh, A. S.; Leach, K. G.; Hughes, L. E.

doi:10.1016/s0140-6736(76)91351-9

Cited by 50 publications

(12 citation statements)

References 10 publications

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“…One of these 13 had obvious lung metastases on her chest X-ray. Three patients in this group had Roberts et al (1976) and McKillop et al (1978). The statement on bone scanning published by the British Breast Group (1978) revealed a very wide variation in the reported incidence of positive bone scans.…”

Section: At I Year Postoperativelymentioning

confidence: 86%

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Bone scanning: Its lack of value in the follow-up of patients with breast cancer

Bishop

Blamey

Morris

et al. 1979

Journal of British Surgery

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Three hundred and fifty-four women with primary operable breast cancer had a bone scan performed within 6 weeks of a simple mastectomy. Eight (2.3 per cent) were positive, but 7 of these patients had radiological evidence of bony metastases. Follow-up bone scans 1 year postoperatively on 278 patients showed only 12 (4.3 per cent) positive, and of these, 9 had other radiological evidence of metastatic disease. At 2 years postoperatively there were 13 (9.2 per cent) positive bone scans amongst 141 patients. Only 2 of these 13 had no other evidence of metastases. Although a bone scan is a useful investigation in patients with bone pain, there is no place for routine bone scanning in either the staging or follow-up of women with operable breast cancer.

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Section: At I Year Postoperativelymentioning

confidence: 86%

“…In the Nottingham study ( Campbell et al, 1976;Roberts et al, 1976) both report a far higher incidence of positive scans. Citrin et al (1974) have pointed out the considerable advantages of a gamma camera over a rectilinear scanner.…”

Section: General Conclusionmentioning

confidence: 98%

Bone scanning: Its lack of value in the follow-up of patients with breast cancer

Bishop

Blamey

Morris

et al. 1979

Journal of British Surgery

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“…Routine radiological skeletal surveys are not sufficiently useful to justify the demand made on X-ray facilities. Patients with small tumours (T 1-2, N 0-1) have a very low pick-up rate for metastases (Citrin et al, 1975;Roberts et al, 1976) whereas 20-40 per cent of this group are positive on isotopic scintigraphy. Nearly all of these scan 'hot spots' become overt metastases in time and influence prognosis (Galasko, 1975a).…”

Section: Tumour Diagnosis and Assessmentmentioning

confidence: 99%

Early breast cancer: Part I: Surgical pathology and preoperative assessment

Hughes¹,

Forbes²

1978

Journal of British Surgery

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“…However, it is also felt that positive scans must have evolved through a suspicious scan phase. The need for increased expertise in the interpretation of scans is undoubted (Roberts et al, 1976). With its attainment the suspicious scan category may be eliminated.…”

Section: Incidence Of Abnormal Scansmentioning

confidence: 99%

“…Its superiority over conventional radiology has led to the recent suggestion that X-ray skeletal surveying should be abandoned and replaced by skeletal scanning (Roberts et al, 1976). The future position of the biochemical indices of dissemination, measured in blood (Roberts, Keyser et al, 1975) and urine (Cushieri, 1975), awaits further study.…”

mentioning

confidence: 99%

The value of preliminary bone scanning in staging and assessing the prognosis of breast cancer

Campbell

Banks

Oates

1976

British Journal of Surgery

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Preliminary bone scans have been performed on all patients with early breast cancer. The incidence of positive scans has been recorded and several factors determining scan status have been enumerated. Particular attention has been focused on the natrual history of scan positive and scan negative patients. Eighteen per cent of stage I and 41 per cent of stage II cancers had positive bone scans. Scan results were correlated with age, menopausal status, tumour position, tumour size and histological node status. Postmenopausal patients were found to have a significantly increased risk of being scan positive (P less than 0-01). Follow-up studies have confirmed that the lesions demonstrated by scanning actually represent metastatic foci. At 18 months 85-7 per cent of scan positive patients had evidence of disseminated disease compared with only 11-4 per cent of scan negative patients (P less than 0-01). Clinically overt advanced disease evolves from positive scan lesions. It is clear that a significant percentage of patients felt to have early breast cancer already have widely disseminated disease at the initial presentation. The biological significance of bone scan lesions makes a sensitive screening test for dissemination an essential part of the preliminary assessment of patients with breast cancer. Bone scans provide an excellent prognostic index at a patient's initial assessment.

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Evaluation of Radiography and Isotopic Scintigraphy for Detecting Skeletal Metastases in Breast Cancer

Cited by 50 publications

References 10 publications

Bone scanning: Its lack of value in the follow-up of patients with breast cancer

Bone scanning: Its lack of value in the follow-up of patients with breast cancer

Early breast cancer: Part I: Surgical pathology and preoperative assessment

The value of preliminary bone scanning in staging and assessing the prognosis of breast cancer

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