Evaluation of (R)-[11C]PK11195 PET/MRI for Spinal Cord-Related Neuropathic Pain in Patients with Cervical Spinal Disorders

Kitade, Makoto; Nakajima, Hideaki; Tsujikawa, Tetsuya; Noriki, Sakon; Mori, Tetsuya; Kiyono, Yasushi; Okazawa, Hidehiko; Matsumine, Akihiko

doi:10.3390/jcm12010116

Cited by 4 publications

(3 citation statements)

References 55 publications

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“…First, we found that sciatic nerve injury furthers the expression of the TSPO in the DRG and the spinal cord. The overexpression of the mitochondrial translocator protein (TSPO) is linked to several pathological conditions like neuropathic pain, cancer, and traumatic brain injury [ 53 , 54 ]. Besides being a marker for neuroinflammation, some evidence suggests that overexpression of TSPO indicates abnormal mitochondrial activity [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function

Awad-Igbaria,

Ferreira,

Keadan

et al. 2023

J Transl Med

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Background Peripheral nerve injury can cause neuroinflammation and neuromodulation that lead to mitochondrial dysfunction and neuronal apoptosis in the dorsal root ganglion (DRG) and spinal cord, contributing to neuropathic pain and motor dysfunction. Hyperbaric oxygen therapy (HBOT) has been suggested as a potential therapeutic tool for neuropathic pain and nerve injury. However, the specific cellular and molecular mechanism by which HBOT modulates the development of neuropathic pain and motor dysfunction through mitochondrial protection is still unclear. Methods Mechanical and thermal allodynia and motor function were measured in rats following sciatic nerve crush (SNC). The HBO treatment (2.5 ATA) was performed 4 h after SNC and twice daily (12 h intervals) for seven consecutive days. To assess mitochondrial function in the spinal cord (L2–L6), high-resolution respirometry was measured on day 7 using the OROBOROS-O2k. In addition, RT-PCR and Immunohistochemistry were performed at the end of the experiment to assess neuroinflammation, neuromodulation, and apoptosis in the DRG (L3–L6) and spinal cord (L2–L6). Results HBOT during the early phase of the SNC alleviates mechanical and thermal hypersensitivity and motor dysfunction. Moreover, HBOT modulates neuroinflammation, neuromodulation, mitochondrial stress, and apoptosis in the DRG and spinal cord. Thus, we found a significant reduction in the presence of macrophages/microglia and MMP-9 expression, as well as the transcription of pro-inflammatory cytokines (TNFa, IL-6, IL-1b) in the DRG and (IL6) in the spinal cord of the SNC group that was treated with HBOT compared to the untreated group. Notable, the overexpression of the TRPV1 channel, which has a high Ca2+ permeability, was reduced along with the apoptosis marker (cleaved-Caspase3) and mitochondrial stress marker (TSPO) in the DRG and spinal cord of the HBOT group. Additionally, HBOT prevents the reduction in mitochondrial respiration, including non-phosphorylation state, ATP-linked respiration, and maximal mitochondrial respiration in the spinal cord after SNC. Conclusion Mitochondrial dysfunction in peripheral neuropathic pain was found to be mediated by neuroinflammation and neuromodulation. Strikingly, our findings indicate that HBOT during the critical period of the nerve injury modulates the transition from acute to chronic pain via reducing neuroinflammation and protecting mitochondrial function, consequently preventing neuronal apoptosis in the DRG and spinal cord.

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Section: Discussionmentioning

confidence: 99%

HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function

Awad-Igbaria,

Ferreira,

Keadan

et al. 2023

J Transl Med

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“…The lack of efficacy of the latter in the study by Ndao and collaborators [ 79 ] might be, at least in part, explained by the small sample size consisting of patients with different diagnoses and treatment histories. Moreover, the lack of reduction of pain intensity using essential oils in some studies can be due to a late start of treatment which can act only as palliative when chronic pain is established, especially for CIPN, while it should be prevented with earlier therapy [ 100 , 101 ]. Therefore, to provide good certainty of the body of evidence for the management of cancer-related pain using essential oils, it is necessary to establish for natural products a step-by-step preclinical-to-clinical pathway to provide a rationale for effective and safe use.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Essential Oils in Relieving Cancer Pain: A Systematic Review and Meta-Analysis

Corasaniti

Bagetta

Morrone

et al. 2023

IJMS

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Over 80% of patients affected by cancer develops cancer-related pain, one of the most feared consequences because of its intractable nature, particularly in the terminal stage of the disease. Recent evidence-based recommendations on integrative medicine for the management of cancer pain underline the role of natural products. The present systematic review and meta-analysis aims at appraising for the first time the efficacy of aromatherapy in cancer pain in clinical studies with different design according to the most updated Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 recommendations. The search retrieves 1002 total records. Twelve studies are included and six are eligible for meta-analysis. The present study demonstrates significant efficacy of the use of essential oils in the reduction of the intensity of pain associated with cancer (p < 0.00001), highlighting the need for earlier, more homogeneous, and appropriately designed clinical trials. Good certainty body of evidence is needed for effective and safe management of cancer-related pain using essential oils by establishment of a step-by-step preclinical-to-clinical pathway to provide a rational basis for clinical use in integrative oncology. PROSPERO registration: CRD42023393182.

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“…The clinical significance of delayed MRI (>2 weeks after injury) was suggested in a prospective study; however, determining the need for surgery and implementing it as soon as possible are both difficult tasks. Other objective assessments, such as machine learning [79][80][81], biomarkers [82][83][84], and novel imaging technologies [85][86][87], are required to evaluate neurological prognoses and treatment strategies. The increased signal intensity grade in delayed MRI displayed a significantly negative correlation with the JOA score; however, this correlation was absent in acute MRI.…”

Section: Discussionmentioning

confidence: 99%

Management of Cervical Spinal Cord Injury without Major Bone Injury in Adults

Nakajima,

Honjoh,

Watanabe

et al. 2023

JCM

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The incidence of cervical spinal cord injury (CSCI) without major bone injury is increasing, possibly because older people typically have pre-existing cervical spinal canal stenosis. The demographics, neurological injury, treatment, and prognosis of this type of CSCI differ from those of CSCI with bone or central cord injury. Spine surgeons worldwide are debating on the optimal management of CSCI without major bone injury. Therefore, this narrative review aimed to address unresolved clinical questions related to CSCI without major bone injury and discuss treatment strategies based on current findings. The greatest divide among spine surgeons worldwide hinges on whether surgery is necessary for patients with CSCI without major bone injury. Certain studies have recommended early surgery within 24 h after injury; however, evidence regarding its superiority over conservative treatment remains limited. Delayed MRI may be beneficial; nevertheless, reliable factors and imaging findings that predict functional prognosis during the acute phase and ascertain the necessity of surgery should be identified to determine whether surgery/early surgery is better than conservative therapy/delayed surgery. Quality-of-life assessments, including neuropathic pain, spasticity, manual dexterity, and motor function, should be performed to examine the superiority of surgery/early surgery to conservative therapy/delayed surgery.

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Evaluation of (R)-[11C]PK11195 PET/MRI for Spinal Cord-Related Neuropathic Pain in Patients with Cervical Spinal Disorders

Cited by 4 publications

References 55 publications

HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function

HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function

Efficacy of Essential Oils in Relieving Cancer Pain: A Systematic Review and Meta-Analysis

Management of Cervical Spinal Cord Injury without Major Bone Injury in Adults

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