Evaluation of quantitative magnetic resonance imaging, biochemical and mechanical properties of trypsin‐treated intervertebral discs under physiological compression loading

Mwale, Fackson; Demers, Caroline N.; Michalek, Arthur J.; Beaudoin, G.; Goswami, Tapas; Beckman, Lorne; Iatridis, James C.; Antoniou, John

doi:10.1002/jmri.21242

Cited by 41 publications

(67 citation statements)

References 36 publications

(66 reference statements)

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“…In view of the previous results, the influence of a day of 16 h of compression loading was evaluated on the disc structure and composition, and the MR parameters [41]. Our results confirmed that MR parameters (T1, T2, MTR, ADC) (Fig.…”

Section: Dynamic Axial Cyclic Compression and Open Systemsupporting

confidence: 88%

“…In regards to AF tissues, we demonstrated that loading decreased T1 but had no effect on T2 and MTR. NP treatment with trypsin neither significantly affected MR parameters nor the biochemical content of the AF tissues [41]. These results strongly suggested that loading history is an important parameter to consider in efforts to develop quantitative MRI as a diagnostic tool of IVD matrix composition and integrity and of biomechanical changes in early IVD degeneration.…”

Section: Dynamic Axial Cyclic Compression and Open Systemmentioning

confidence: 85%

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Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity

2008

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Degenerative disc disease has been implicated as a major component of spine pathology. The current major clinical procedures for treating disc degeneration have been disappointing, because of altered spinal mechanics leading to subsequent degeneration at adjacent disc levels. Disc pathology treatment is shifting toward prevention and treatment of underlying etiologic processes at the level of the disc matrix composition and integrity and the biomechanics of the disc. The ability to perform such treatment relies on one's ability to accurately and objectively assess the state of the matrix and the effectiveness of treatment by a non-invasive technique. In this review, we will summarize our advances in efforts to develop an objective, accurate, non-invasive diagnostic tool (quantitative MRI) in the detection and quantification of matrix composition and integrity and of biomechanical changes in early intervertebral disc degeneration.

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Section: Dynamic Axial Cyclic Compression and Open Systemsupporting

confidence: 88%

Section: Dynamic Axial Cyclic Compression and Open Systemmentioning

confidence: 85%

Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity

2008

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“…Preliminary in-vitro work has shown correlations between magnetic resonance images and disc mechanical properties (Campana et al, 2011;Cortes et al, 2014;Mwale et al, 2008;Périé et al, 2006;Recuerda et al, 2012), but in-vivo applications are still lacking. Moreover, cost and accessibility of magnetic resonance imaging represent an issue when considering large scale routine clinical use.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

et al. 2014

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Objectives: Although magnetic resonance is widely spread to qualitatively assess disc morphology, a simple method to reliably determine intervertebral disc status is still lacking. Shear wave elastography is a recent technique that allows quantitative evaluation of soft-tissues mechanical properties; the aim of this study was to preliminary assess the feasibility and reliability of cervical intervertebral disc mechanical characterization by elastography and to provide first reference values for asymptomatic subjects.Methods: Elastographic measurements were performed to determine shear wave speed (SWS) in C6-C7 or C7-T1 disc of forty-seven subjects; repeatability and inter-operator reproducibility were assessed.Results: Global average shear wave speed (SWS) was 3.0 ± 0.4 m/s; measurement repeatability and inter-user reproducibility were 7 and 10 %, respectively. SWS was correlated with both subject's age (p = 1.3e-5) and body mass index (p = 0.008).Conclusions: Shear wave elastography in intervertebral disc proved reliable and allowed stratification of subjects according to age and BMI. Applications could be relevant, for instance, in early detection of disc degeneration or in follow-up after trauma; these results open the way to larger cohort studies to define the place of this technique in routine intervertebral disc assessment.

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“…More invasive measuring techniques are also being explored [23], but they can only be applied during surgery. Direct and non-invasive measurement techniques to assess spine flexibility are still lacking, although preliminary results have been reported in IVD mechanical characterization with magnetic resonance imaging [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Intervertebral disc characterization by shear wave elastography: An in vitro preliminary study

Vergari

Rouch

Dubois

et al. 2014

Proc Inst Mech Eng H

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Science Arts & Métiers (SAM)is an open access repository that collects the work of Arts et Métiers ParisTech researchers and makes it freely available over the web where possible. properties remains a challenge. Ultrasound elastography is a relatively recent measurement technique allowing the evaluation of soft tissue's elastic modulus through the measurement of shear wave speed (SWS). The aim of this study was to determine the feasibility of elastographic measurements in intervertebral disc (IVD). An in-vitro approach was chosen to test the hypothesis that SWS can be used to evaluate IVD mechanical properties and to assess measurement repeatability. Eleven oxtail IVDs were tested in compression to determine their stiffness and apparent elastic modulus at rest and at 400 N. Elastographic measurements were performed in these two conditions and compared to these mechanical parameters. The protocol was repeated six times to determine elastographic measurement repeatability. Average SWS over all samples was 5.3 ± 1.0 m/s, with a repeatability of 7 % at rest and 4.6 % at 400 N; stiffness and apparent elastic modulus were 266.3 ± 70.5 N/mm and 5.4 ± 1.1 MPa at rest, respectively, while at 400 N they were 781.0 ± 153.8 N/mm and 13.2 ± 2.4 MPa. Correlations were found between elastographic measurements and IVD mechanical properties; these preliminary results are promising for further in-vivo application.

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Evaluation of quantitative magnetic resonance imaging, biochemical and mechanical properties of trypsin‐treated intervertebral discs under physiological compression loading

Cited by 41 publications

References 36 publications

Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity

Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

Intervertebral disc characterization by shear wave elastography: An in vitro preliminary study

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