Evaluation of protective efficacy of Spirulina platensis against collagen-induced arthritis in rats

Kumar, Narendra; Singh, Surendra; Patro, Nisha

doi:10.1007/s10787-009-0004-1

Cited by 50 publications

(32 citation statements)

References 47 publications

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“…However, W. somnifera treated arthritic rats at a dose of 600 mg kg À1 showed a significant increase in their body weight in comparison to their arthritic control counterparts. Similar increment in body weight in CIA rat following their treatment with Spirulina platensis and Spirulina fusiformis has also been reported (Kumar et al, 2009;.…”

Section: Discussionsupporting

confidence: 80%

“…Arthritic pain of arthritic control, W. somnifera (600 and 800 mg kg À1 ) and methotrexate (0.3 mg kg À1 ) treated arthritic rats were evaluated using the foot-print assessment of pain that reflects the spontaneous pain behavior Kumar, 2011). The rat's hind paws were dipped in ink and the animals were allowed to walk on white paper for a distance of 60 cm from day 20th to 45th day.…”

Section: Measurement Of Arthritic Painmentioning

confidence: 99%

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Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats

Gupta

Singh

2013

Pharmaceutical Biology

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Context: Withania somnifera (Linn.) Dunal (Solanaceae) has long been used as an herb in Ayurvedic and indigenous medicine and has received intense attention in recent years for its chemopreventive properties. Objective: The present study focuses on the effect of W. somnifera root powder on the behavioral and radiological changes in collagen-induced arthritic rats. Materials and methods: The rats were randomly divided into five groups: normal control, arthritic control, arthritic rats treated with W. somnifera root powder (at dose levels 600 and 800 mg kg À1) and arthritic rats treated with methotrexate (at dose level 0.3 mg kg À1). The treatment with W. somnifera (daily) and methotrexate (weekly) was initiated from the 20th day post collagen immunization and continued up until the 45th day. Arthritis was assessed macroscopically by measuring paw thickness, ankle size and body weight. Arthritic pain was assessed by toe-spread and total print length of the affected paw. Functional recovery due to the oral treatment of W. somnifera and methotrexate was assessed by sciatic functional index and rota rod activity. Results: Administration of W. somnifera root powder (600 mg kg À1) to the arthritic rats significantly decreased the severity of arthritis by effectively suppressing the symptoms of arthritis and improving the functional recovery of motor activity and radiological score. Discussion and conclusion: W. somnifera root has a protective effect against collagen-induced arthritis (CIA) in rats. The results suggest that W. somnifera root powder acts as an antiinflammatory and antioxidant agent in decreasing the arthritic effects in collagen-induced arthritic rats.

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Section: Discussionsupporting

confidence: 80%

Section: Measurement Of Arthritic Painmentioning

confidence: 99%

Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats

Gupta

Singh

2013

Pharmaceutical Biology

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“…The clinical pathological features of this animal model of arthritis are similar to the human rheumatoid arthritis [9][10][11]. There were no significant changes in body weight with collagen-induced arthritis in this study.…”

Section: Discussionmentioning

confidence: 59%

Modulation of C-reactive protein and tumour necrosis factor-alpha in collagen-induced arthritis in Dark Agouti rats: impact of collagen concentration on severity of arthritis

et al. 2011

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“…In recent years, Arthrospira (Spirulina) platensis (SP), a cyanobacterium or more commonly a blue green alga, that belongs to the Oscillatoraceae family (Kumar et al 2009;El-Desoky & Bashandy 2013), has gained more attention from medical scientists for the treatment of a wide spectrum of diseases (Sharma et al 2007). Several studies have attributed various pharmacological properties to SP including anticarcinogenic, immunostimulant, antiviral, hypocholesterolemic, and hypoglycaemic actions (Khan et al 2005;Kulshreshtha et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect ofArthrospira(Spirulina)platensisagainst kainic acid-neuronal death

Pérez-Juárez

Chamorro²,

Alva-Sánchez

et al. 2016

Pharmaceutical Biology

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Context Arthrospira (Spirulina) platensis (SP) is a cyanobacterium which has attracted attention because of its nutritional value and pharmacological properties. It was previously reported that SP reduces oxidative stress in the hippocampus and protects against damaging neurobehavioural effects of systemic kainic acid (KA). It is widely known that the systemic administration of KA induces neuronal damage, specifically in the CA3 hippocampal region. Objective The present study determines if the SP sub-chronic treatment has neuroprotective properties against KA. Materials and methods Male SW mice were treated with SP during 24 d, at doses of 0, 200, and 800 mg/kg, once daily, and with KA (35 mg/kg, ip) as a single dose on day 14. After the treatment, a histological analysis was performed and the number of atrophic neuronal cells in CA3 hippocampal region was quantified. Results Pretreatment with SP does not protect against seizures induced by KA. However, mortality in the SP 200 and the SP 800 groups was of 20%, while for the KA group, it was of 60%. A single KA ip administration produced a considerable neuronal damage, whereas both doses of SP subchronic treatment reduced the number of atrophic neurons in CA3 hippocampal region with respect to the KA group. Discussion The SP neurobehaviour improvement after KA systemic administration correlates with the capacity of SP to reduce KA-neuronal death in CA3 hippocampal cells. This neuroprotection may be related to the antioxidant properties of SP. Conclusion SP reduces KA-neuronal death in CA3 hippocampal cells. ARTICLE HISTORY

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Evaluation of protective efficacy of Spirulina platensis against collagen-induced arthritis in rats

Abstract: S. platensis (400 mg kg(-1)) significantly normalizes changes observed in arthritic rats to near normal conditions, indicates that S. platensis has promising protective efficacy against CIA rats.

Cited by 50 publications

References 47 publications

Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats

Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats

Modulation of C-reactive protein and tumour necrosis factor-alpha in collagen-induced arthritis in Dark Agouti rats: impact of collagen concentration on severity of arthritis

Neuroprotective effect ofArthrospira(Spirulina)platensisagainst kainic acid-neuronal death

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