Evaluation of Protective Effect of Different Doses of  Terminalia arjuna Bark Ethanolic Extract on Cisplatin Induced Oxidative Nephrotoxicity in Rats

Eggadi, Venkateshwarlu; Korupozu, Sharath Chandra; Korupoju, Bharath kumar; Sheshagiri, Sharavanabhava Bandaru; R, Shiva Kumar; Jupally, Venkateshwar Rao

doi:10.31351/vol23iss2pp89-98

Cited by 2 publications

(2 citation statements)

References 23 publications

(21 reference statements)

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“…Cisplatin has emerged as a panacea for treating all types of cancers [ 25 ]. However, exceeding the recommended dosage may lead to infrequent yet severe side effects such as hepatotoxicity [ 26 ]. Its use is associated with certain limitations, such as the potential for nausea, vomiting, electrolyte imbalances, hemolytic anemia, and neurotoxicity [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…After seven consecutive days of oral alpha-tocopherol administration (100 mg/kg), mice in this group received a solitary intraperitoneal dose of cisplatin (10 mg/ kg) on the eighth day [19][20][21][22][23][24]. After a twenty-four-hour interval since the last administered dose, blood samples were collected from the mice, which were subsequently euthanized by cervical dislocation.…”

Section: Group 5 -Alpha-tocopherol Treatment Vitamin E (At)mentioning

confidence: 99%

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Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice

Abd Alhusen,

Hasan

2023

JMedLife

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Fatty acids, particularly omega-3, omega-6, and omega-9, play a vital role in various biological processes. As the body cannot synthesize omega-3 and omega-6, dietary sources of these fatty acids are essential. Each omega fatty acid has a distinct chemical structure, source, and function. Cisplatin (CP) treatment is known to cause acute kidney injury (AKI) due to its inflammatory effects. This study explored the renoprotective potential of omega-3-6-9 when co-administered with cisplatin in a mice model. We divided adult mice into five groups: a control group received 0.5 ml of liquid paraffin; a cisplatin-only group; two groups were treated with low (50 mg/kg) and high (100 mg/kg) doses of omega-3-6-9 plus cisplatin; and a final group received vitamin E before cisplatin administration. The administration of omega-3-6-9 significantly decreased pro-inflammatory modulators and kidney function markers such as TNF-α, IL-1β, blood urea nitrogen, and creatinine, indicating potential renoprotective effects. Our research concluded that omega-3- 6- 9 had anti-inflammatory properties and was effective against the harmful effects of cisplatin.

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Section: Discussionmentioning

confidence: 99%

Section: Group 5 -Alpha-tocopherol Treatment Vitamin E (At)mentioning

confidence: 99%

Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice

Abd Alhusen,

Hasan

2023

JMedLife

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Formulation and evaluation of nanobiotherapeutics of Terminalia arjuna through plant tissue culture for atherosclerosis

Wadekar,

Salunkhe

2024

Futur J Pharm Sci

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Background The study seeks to investigate the therapeutic potential of Terminalia arjuna callus in addressing atherosclerosis. In order to get maximum beneficial phytoconstituents from Terminalia arjuna, it is recommended to harvest the bark from Arjuna trees that are at least 15 years old and a gap of minimum 2 years should be kept before harvesting bark from the same plant. The callus culture technique was employed to expedite the process. The callus culture extract was subsequently converted into a nanosuspension with the aim of improving the efficacy of its phytoconstituents. It was then subjected to a comprehensive series of in vitro and in vivo evaluations to ascertain its potential for treatment of atherosclerosis. Results Liquid chromatography–mass spectrometry analysis of the callus extract confirmed the presence of flavonoids and terpenoids, known for their antioxidant and anti-inflammatory activities. Some terpenoids were even absent in Arjuna tree naturally. TEM images validated successful entrapment of the extract within the nanoparticles. In vitro analysis for antilipase and antioxidant assay confirmed the antiatherosclerotic potential of the extract. In vivo tests on rat blood serum demonstrated a significant reduction in total cholesterol, low-density lipoprotein, triglycerides, high-density lipoprotein, and very low-density lipoprotein. Histopathological analysis of rat aortas showed additional confirmation of antiatherosclerotic action. Conclusion In conclusion, the study highlights the potential of nanosuspension derived from Terminalia arjuna callus extract as a comprehensive therapeutic strategy for atherosclerosis treatment. The research highlights antioxidant, anti-inflammatory, and antiatherosclerotic properties of the callus, hinting at its viability as a potential treatment for atherosclerosis. This interdisciplinary investigation emphasizes the promising role of traditional medicinal plants within modern medical paradigms.

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Evaluation of Protective Effect of Different Doses of Terminalia arjuna Bark Ethanolic Extract on Cisplatin Induced Oxidative Nephrotoxicity in Rats

Cited by 2 publications

References 23 publications

Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice

Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice

Formulation and evaluation of nanobiotherapeutics of Terminalia arjuna through plant tissue culture for atherosclerosis

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