Evaluation of proteasomal gene polymorphisms in Lithuanian patients with asthma

Žemeckienė, Živilė; Šitkauskienė, Brigita; Gasiūnienė, Edita; Paramonova, Natalia; Tamašauskienė, Laura; Vitkauskienė, Astra; Sjakste, Tatjana; Sakalauskas, Raimundas

doi:10.3109/02770903.2014.982761

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…In IPF, TGF‐β increases the expression of proteasome 20S subunit alpha 2 (PSMA2), leading to inflammation and pulmonary fibrosis. In asthma, PSMA2 expression causes inflammation by activating the NF‐κB and producing inflammatory cytokines 205 . In COPD, PSMA2 activates NF‐κB and caspase3, causing lung cell apoptosis and worsening patients' clinical course.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review

Rezaeeyan,

Arabfard,

Rasouli

et al. 2023

Immunity Inflam & Disease

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AimRespiratory disease (RD) is one of the most common diseases characterized by lung dysfunction. Many diagnostic mechanisms have been used to identify the pathogenic agents of responsible for RD. Among these, proteomics emerges as a valuable diagnostic method for pinpointing the specific proteins involved in RD pathogenesis. Therefore, in this study, for the first time, we examined the protein markers involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), asthma, bronchiolitis obliterans (BO), and chemical warfare victims exposed to mustard gas, using the proteomics method as a systematic study.Materials and MethodsA systematic search was performed up to September 2023 on several databases, including PubMed, Scopus, ISI Web of Science, and Cochrane. In total, selected 4246 articles were for evaluation according to the criteria. Finally, 119 studies were selected for this systematic review.ResultsA total of 13,806 proteins were identified, 6471 in COPD, 1603 in Asthma, 5638 in IPF, three in BO, and 91 in mustard gas exposed victims. Alterations in the expression of these proteins were observed in the respective diseases. After evaluation, the results showed that 31 proteins were found to be shared among all five diseases.ConclusionAlthough these 31 proteins regulate different factors and molecular pathways in all five diseases, they ultimately lead to the regulation of inflammatory pathways. In other words, the expression of some proteins in COPD and mustard‐exposed patients increases inflammatory reactions, while in IPF, they cause lung fibrosis. Asthma, causes allergic reactions due to T‐cell differentiation toward Th2.

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Section: Discussionmentioning

confidence: 99%

“…In asthma, PSMA2 expression causes inflammation by activating the NF-κB and producing inflammatory cytokines. 205 In COPD, PSMA2 activates NF-κB and caspase3, causing lung cell apoptosis and worsening patients' clinical course. Thus, targeting RBP4 prevents inflammation and reduces apoptosis (Figure 2).…”

Section: Proteomic Biomarkersmentioning

confidence: 99%

Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review

Rezaeeyan,

Arabfard,

Rasouli

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

“…The proteasome gene, PMSA6, encodes the a1 protein, which is involved in the formation of the outer rings of the 20s core proteasome and is subject to post-translational regulation (Choudhary et al, 2009;Wang et al, 2013). The location of the PSMA6 gene occurs in a region containing microsatellites that have been implicated in coronary artery disease (CAD) (Alsmadi et al, 2009), type 2 diabetes mellitus (T2DM) (Sjakste et al, 2007), Grave's disease (Sjakste et al, 2004), asthma (Zemeckiene et al, 2015), ankylosing spondylitis (Zhao et al, 2015), and myocardial infarction (Liu et al, 2009). In a lung cancer study, the expression of PSMA6 was up-regulated, and knocking out PSMA6 could induce lung cancer tumor cell apoptosis or the cell cycle to enter the arrest phase (Kakumu et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of an RNA-Binding Protein-Based Prognostic Model for Ovarian Serous Cystadenocarcinoma

Zeng

et al. 2020

Front. Genet.

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Ribonucleic acid-binding proteins (RBPs) are reportedly involved in tumor progression and recurrence; however, the functions and mechanisms of action of RBPs in ovarian serous cystadenocarcinoma (OSC) are not known. To address these issues, gene expression profiles of OSC tissues from The Cancer Genome Atlas (TCGA) and normal tissues from the Genotype-Tissue Expression database were compared in order to identify RBPs that are differentially expressed in OSC. We also analyzed the biological functions of these RBPs and their relationship to clinical outcome. There were 190 RBPs that were differentially expressed between OSC and normal tissues, including 93 that were upregulated and 97 that were downregulated. Five of the RBPs were used to construct a prediction model that was evaluated by univariate and multivariate Cox regression analyses. TCGA data were randomly divided into training and test cohorts, and further categorized into high-and low-risk groups according to risk score in the model. The overall survival (OS) of the high-risk group was shorter than that of the low-risk group (training cohort P = 0.0007596; test cohort P = 0.002219). The area under the receiver operating characteristic curve of the training and test cohorts was 0.701 and 0.638, respectively, demonstrating that the model had good predictive power. A nomogram was established to quantitatively describe the relationship between the five prognostic RBPs and OS in OSC, which can be useful for developing individualized management strategies for patients.

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Evaluation of proteasomal gene polymorphisms in Lithuanian patients with asthma

Cited by 2 publications

References 22 publications

Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review

Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review

Development and Validation of an RNA-Binding Protein-Based Prognostic Model for Ovarian Serous Cystadenocarcinoma

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