Evaluation of prognostic factors in the surgical treatment of adrenal gland tumors in dogs: 41 cases (1999–2005)

Abstract

A high mortality rate was associated with adrenalectomy in dogs; however, those that survived until discharge from a hospital had long survival times. Preoperative factors associated with a shorter survival time were weakness or lethargy, thrombocytopenia, increased BUN concentration, increased PTT, increased AST activity, and hypokalemia. Studies are needed to evaluate how treatment for these factors may affect or change outcome after adrenalectomy. Dogs with adrenal masses that require concurrent nephrectomy and cause intraoperative hemorrhage have a guarded prognosis.

Long‐Term Survival of Dogs with Adrenal‐Dependent Hyperadrenocorticism: A Comparison between Mitotane and Twice Daily Trilostane Treatment

“…This survival time is lower compared to dogs in which adrenalectomy is performed (23–31.8 months) 5, 6. When surgery is performed and the tumor is removed, the risk of tumor spreading is minimized (ie, growth of the tumor, invasion of blood vessels), the treatment can be curative in most of the patients, and also the adverse effects of lifelong hypercortisolism are prevented.…”

“…In addition, adrenalectomy has reported frequencies of intraoperative and postoperative complications of 15–50% of affected dogs, respectively. Perioperative mortality rate of adrenalectomy is high (5–29%)3, 4, 5, 6 and this could lead to unwillingness of the owner to accept the risk of this procedure. When surgery is not indicated or the owner declines surgery, medical management with the adrenocorticolytic drug mitotane has been recommended as an alternative treatment.…”

Adrenalectomy in dogs: retrospective study of 13 cases performed in Universidade Anhembi Morumbi Veterinary Hospital (2012-2015)

“…On the other hand, Lang et al (2011), Naan et al (2013) and Andrade et al (2014) showed a very similar incidence between males and females (55.5% females). The ascertained breeds, there was a heterogeneous representation in the group, noting that Labradors were reported by Schwartz et al (2008), Lang et al (2011), Massari et al (2011, Naan et al (2013) and Andrade et al (2014), followed by Shih-Tzus - Schwartz et al (2008), Lang et al (2011) and Massari et al (2011). Throughout the literature, the condition has been reported to also occur in mixed breed's dogs (PELÁEZ et al, 2008;LANG et al, 2011;MASSARI et al, 2011;BARRERA et al, 2013;NAAN et al, 2013).…”

“…Related to adrenalectomy in dogs with hyperadrenocorticism caused by adrenocortical tumors, Van Sluijs et al (1995) reported a small but substantial hypercortisolemia recurrence development index after adrenalectomy, confirmed by measuring urinary cortisol or cortisol suppression by dexamethasone. Moreover, there is the possibility of occurrence of metastases, which also result in the recurrence of the clinical state (LANG et al, 2011).…”

“…However, adrenalectomy is associated with a high rate of perioperative mortality in dogs (SCHWARTZ et al, 2008). On the other hand, Massari et al (2011) found a mean survival time greater than 10 months, postoperatively.…”