Evaluation of progenitor cell cultures from human embryos for neurotransplantation

Полтавцева, Р. А.; Marey, Maria V.; Александрова, М. А.; Revishchin, A. V.; Korochkin, L. I.; Сухих, Г. Т.

doi:10.1016/s0165-3806(02)00274-2

Cited by 34 publications

(23 citation statements)

References 27 publications

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“…95,117 The last precursor and progenitor cell marker to be discussed here is the intermediate filament protein, nestin, which has been used as a marker for neural precursors. 118,119 At one time, nestin was thought to determine neural lineage exclusively; however, this protein has also been found in endothelial cells, embryonic tissues, glioblastoma multiforme, and many melanomas. 119 Therefore, although nestin can be used as a marker for neural progenitors and precursors, its specificity is no longer accepted.…”

Section: Identifying Differentiated Hescs and Hnscsmentioning

confidence: 99%

Therapeutic Potentials of Human Embryonic Stem Cells in Parkinson’s Disease

Newman

Bakay

2008

Neurotherapeutics

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Summary:The loss of dopaminergic neurons of the substantia nigra is the pathological hallmark characteristic of Parkinson's disease (PD). The strategy of replacing these degenerating neurons with other cells that produce dopamine has been the main approach in the cell transplantation field for PD research. The isolation, differentiation, and long-term cultivation of human embryonic stem cells and the therapeutic research discovery made in relation to the beneficial properties of neurotrophic and neural growth factors has advanced the transplantation field beyond dopamine-producing cells. The present review addresses recent advances in human embryonic stem cell experimentation in relation to treating PD, as well as cell transplantation techniques in conjunction with alternative therapeutics.

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Section: Identifying Differentiated Hescs and Hnscsmentioning

confidence: 99%

Therapeutic Potentials of Human Embryonic Stem Cells in Parkinson’s Disease

Newman

Bakay

2008

Neurotherapeutics

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“…Expression of surface markers A2B5 which recognizes an epitope common to neurons, neuroendocrine, and glial cells, and the polysialylated form of neural cell adhesion molecule (PSA-NCAM) have been used to select NSCs from murine (Redies et al, 1991;Mujtaba et al, 1999), human ES cell cultures (Thomas et al, 2000;Carpenter et al, 2001) and human fetal brain (Dietrich et al, 2002). Nestin, an intermediate filament protein, is a neural precursor cell marker that has been expressed in rat (Lendahl et al, 1990), mice (Reynolds and Weiss, 1992;Palmer et al, 1999), and humans (Johansson et al, 1999;Shih et al, 2001;Poltavtseva et al, 2002). Although nestin has been used extensively to determine cells of neural linage, this marker has also been found in endothelial cells, embryonic tissues, glioblastoma mulitformes, and many melanomas (as reviewed in Mokry and Nemecek, 1998;Shih et al, 2001), therefore, it is not specific to the CNS.…”

Section: Phenotyping Of Hucb Cellsmentioning

confidence: 99%

Human umbilical cord blood (HUCB) cells for central nervous system repair

et al. 2003

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Cellular therapy is a compelling and potential treatment for certain neurological and neurodegenerative diseases as well as a viable treatment for acute injury to the spinal cord and brain. The hematopoietic system offers alternative sources for stem cells compared to those of fetal or embryonic origin. Bone marrow stromal and umbilical cord cells have been used in pre-clinical models of brain injury, directed to differentiate into neural phenotypes, and have been related to functional recovery after engraftment in central nervous system (CNS) injury models. This paper reviews the advantages, utilization and progress of human umbilical cord blood (HUCB) cells in the neural cell transplantation and repair field.

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“…We studied the effect of the status of recipient brain and the regimen of culturing of the transplanted material on the behavior of human fetal cells transplanted into rat brain [1][2][3][4][5]7,12].…”

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confidence: 99%

Human Fetal Neural Stem Cells in Rat Brain: Effects of Preculturing and Transplantation

et al. 2005

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The fate of human fetal stem/progenitor cells transplanted into rat brain depends on conditions of preculturing (long or short) and state and site of transplantation. Human nestin-positive stem cells cultured according to the short protocol did not migrate into hypoxic and normal brain after transplantation, but actively migrated in damaged spinal cord. After transplantation of long-cultured cells into the brain mainly committed neuroblasts and solitary nestin-positive cells migrated from the site of transplantation into the brain.

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Evaluation of progenitor cell cultures from human embryos for neurotransplantation

Cited by 34 publications

References 27 publications

Therapeutic Potentials of Human Embryonic Stem Cells in Parkinson’s Disease

Therapeutic Potentials of Human Embryonic Stem Cells in Parkinson’s Disease

Human umbilical cord blood (HUCB) cells for central nervous system repair

Human Fetal Neural Stem Cells in Rat Brain: Effects of Preculturing and Transplantation

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