Evaluation of prescribing pattern of NSAIDs in south Indian teaching hospital

Abstract

The present study was aimed to appropriateness of NSAIDs use with secondary objectives of assessment of co-prescription with gastro-protective agents, the nature and severity of adverse drug reactions and drug-drug interactions with an intention to prevent the inappropriate use of NSAIDs. A prospective study was carried out in 400 In-patients of various departments of the hospital during the 6 months period. Results: Out of 400 patients, 237 were male and 163 were females, in which most of the patients (63.5%) were belonging to age group of 21-50years. The major complaint of the patient was arthritic pain (25.5%). Most of the patients (77%) were prescribed single NSAID as monotherapy in different dosage forms, although some patients were prescribed with combination of Aceclofenac + Paracetamol (13.75%). The preferential COX-2 inhibitors were widely prescribed (84.5%) as compared to non-selective COX inhibitor (15.5%). Among various NSAIDs prescribed, Diclofenac (45.90%) and Aceclofenac (15.96%) were mostly prescribed. NSAIDs were mostly prescribed by parenteral route (36.31%). Most of the patients were co-prescribed NSAIDs with gastro-protective agents (80.5%). In the study, moderate drug interactions were found between NSAIDs and antibiotics and no adverse drug reactions were reported during the study. The study concluded that, prescription of NSAIDs was found to be rational. Education program, counselling program, alertness of community pharmacy regarding OTC drugs can be helpful to minimize harmful effect of the drug to patients.

Quantification of ketoprofen in film-coated tablets using hydrophilic interaction liquid chromatography-Ultraviolet spectrometry

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used worldwide for analgesic, antiinflammatory, and antipyretic properties [1]. Globally, NSAIDs are the most frequently prescribed drugs, accounting for around 5-10% of all medications prescribed each year [2].…”

Prescription Pattern Analysis of Non-Steroidal Anti-Inflammatory Drugs in Tertiary Care Hospital

“…Irrational prescribing and drug usage have become a global problem in the system of health care delivery in recent years [1].…”

“…NSAIDs have been a chosen option for majority of patient attending the hospital with pain as a common symptom for most illnesses since their disclosure as pain, anti-inflammatory, and anti-pyretic. They have become the first line treatment for the pain in the past two decades and they have played a key part in pain management [1].…”

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Usage and co-prescription with other potentially interacting drugs in elderly: A cross-sectional study

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are used all over the world for their analgesic, anti-inflammatory, and antipyretic effects [1]. NSAIDs are among the most commonly prescribed class of medications globally and they account for approximately 5-10% of all medications prescribed each year [2].…”