Evaluation of Pregnancy Outcomes at Advanced Maternal Age

Radoń-Pokracka, Małgorzata; Adrianowicz, Beata; Płonka, Magdalena; Danił, Paulina; Nowak, Magdalena; Huras, Hubert

doi:10.3889/oamjms.2019.587

Cited by 32 publications

(32 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our group of 563 participants (in the current analysis), the frequency of the pregnancy outcomes (8.4% of the deliveries were <37th week; 8.5% of the women gave birth to newborn <10th percentile, and 11.4% gave birth to newborn >90th percentile) was close to the frequency in other Polish studies [43,44]. In our analysis, the frequency of main complications (21.3% of the women have developed PIH and 19.5% have developed GDM) was about 2-4 times higher compared to the frequency in several Polish studies [43,45,46]. At the same time, among our participants, 40.7% of the women were primiparous, 39.1% had prepregnancy BMI ≥25 kg/m 2 , and 63.6% were ≥35 years.…”

Section: Discussionsupporting

confidence: 81%

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Lewandowska

Więckowska

Sajdak³

et al. 2020

Nutrients

View full text Add to dashboard Cite

Microelements involved in the oxidative balance have a significant impact on human health, but their role in pregnancy are poorly studied. We examined the relationships between first trimester levels of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu), as well as maternal characteristics and pregnancy results. The data came from a Polish prospective cohort of women in a single pregnancy without chronic diseases. A group of 563 women who had a complete set of data, including serum microelements in the 10–14th week was examined, and the following were found: 47 deliveries <37th week; 48 cases of birth weight <10th and 64 newborns >90th percentile; 13 intrauterine growth restriction (IUGR) cases; 105 gestational hypertension (GH) and 15 preeclampsia (PE) cases; and 110 gestational diabetes mellitus (GDM) cases. The microelements were quantified using mass spectrometry. The average concentrations (and ranges) of the elements were as follows: Se: 60.75 µg/L (40.91–125.54); Zn: 618.50 µg/L (394.04–3238.90); Cu: 1735.91 µg/L (883.61–3956.76); and Fe: 1018.33 µg/L (217.55–2806.24). In the multivariate logistic regression, we found that an increase in Se of 1 µg/L reduces the risk of GH by 6% (AOR = 0.94; p = 0.004), the risk of IUGR by 11% (AOR = 0.89; p = 0.013), and the risk of birth <34th week by 7% (but close to the significance) (AOR = 0.93; p = 0.061). An increase in Fe of 100 µg/L reduces the risk of PE by 27% (AOR = 0.73; p = 0.009). In the multivariable linear regression, we found negative strong associations between prepregnancy BMI, Se (β = −0.130; p = 0.002), and Fe (β = −0.164; p < 0.0001), but positive associations with Cu (β = 0.320; p < 0.000001). The relationships between Se and maternal age (β = 0.167; p < 0.0001), Se and smoking (β = −0.106; p = 0.011) and Cu, and gestational age from the 10–14th week (β = 0.142; p < 0.001) were also found. Secondary education was associated with Zn (β = 0.132; p = 0.004) and higher education was associated with Cu (β = −0.102; p = 0.023). A higher financial status was associated with Fe (β = 0.195; p = 0.005). Other relationships were statistically insignificant. Further research is needed to clarify relationships between first trimester microelements and pregnancy complications. In addition, attention should be paid to lifestyle-related and socioeconomic factors that affect microelement levels.

show abstract

Section: Discussionsupporting

confidence: 81%

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Lewandowska

Więckowska

Sajdak³

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…The analysis of our results requires highlighting a few facts. The frequency of all PIH cases in our cohort ( n = 137 = 15.0%) is 2–3 times higher than in other Polish studies [ 26 , 27 ]. The probable reason for this is the fact that the study was performed in a third-degree reference center, where women with risk factors report for additional tests.…”

Section: Discussioncontrasting

confidence: 68%

The Influence of Various Smoking Categories on The Risk of Gestational Hypertension and Pre-Eclampsia

Lewandowska

Więckowska

2020

JCM

View full text Add to dashboard Cite

The relationship between smoking and the risk of pregnancy-induced hypertension (PIH) is not clearly established. Therefore, we conducted an analysis of cigarette smoking in a Polish cohort of women, recruited in the first trimester of a single pregnancy in 2015–2016. We evaluated the women who subsequently developed PIH (n = 137) (gestational hypertension—GH (n = 113) and pre-eclampsia—PE (n = 24)), and the women who remained normotensive (n = 775). The diseases odds ratios (and 95% CI—confidence intervals) were calculated in a multivariate logistic regression. In the PIH cases (vs. normotensive women) we found more smokers (25.6% vs. 17.2%, p = 0.020) including smokers in the first trimester (14.6% vs. 4.8%, p < 0.001). The average number of cigarettes smoked daily per smokers in the first trimester was 11.2 (range 2–30), and the average number of years of smoking was 11.6 (range 2–25). The number of years of smoking was a stronger risk factor for GH and PE than the number of cigarettes/day. Compared to the women who have never smoked, smoking ever before pregnancy was associated with a higher GH risk (AOR = 1.68; p = 0.043), and with no effect on PE risk (OR = 0.97; p = 0.950). Smokers in the first trimester had a higher odds ratio of GH (AOR = 4.75; p < 0.001) and PE (OR = 2.60; p = 0.136). Quitting smoking before pregnancy (ex-smokers) was associated with a lower odds ratio of GH (AOR = 0.83; p = 0.596) and PE (OR = 0.33; p = 0.288). However, quitting smoking during pregnancy was associated with a higher risk of GH (AOR = 11.63; p < 0.0001) and PE (OR = 3.57; p = 0.238). After dissection of the cohort into pre-pregnancy body–mass index (BMI) categories, smoking in the first trimester was associated with the higher hypertension risk in underweight women (OR = 22.00, p = 0.024). Conclusions: The factors that increased the risk of GH and PE were smoking in the first trimester and (paradoxically and more strongly) smoking cessation during pregnancy. Our results suggest that women of childbearing potential should be encouraged to quit smoking before pregnancy.

show abstract

“…In this study, mothers aged 35 were one of the contributing factors to birth asphyxia rates. The following discovery was very nearly found to be a universal fact: the increased age of the mother increased the risk of several adverse outcomes [32][33][34]. Similar findings were also reported from a study carried out in Cameroon [20] which revealed that mothers aged 35 were more likely to experience a birth asphyxia.…”

Section: Discussionsupporting

confidence: 61%

Birth asphyxia and its contributing factors among the neonates delivered at Negest Eleni Mohammed memorial teaching hospital, Southern Ethiopia: A cross-sectional study

Ahmed

Halil

Kebede

et al. 2019

Preprint

View full text Add to dashboard Cite

Background : Birth asphyxia is a major contributor to neonatal mortality worldwide. In Ethiopia, birth asphyxia remains a severe condition that leads to significant mortality and morbidity. This study aimed to assess the prevalence and contributing factors of birth asphyxia among the neonates delivered at the Negest Eleni Mohammed Memorial Teaching Hospital, Southern Ethiopia. Methods: A hospital based cross-sectional study design was employed from June 1- 30, 2019. Two hundred seventy nine study participants were selected using the systematic sampling method. Data were collected using a pretested structured interviewer administered questionnaire, check list and chart review . Data were entered into Epi-data version 3.1 and analyzed using statistical package for social sciences version 24. Descriptive and binary logistic regression analysis were made and P value of < 0.05 was considered significant. Result: The overall prevalence of birth asphyxia among newborns was 15.1%. Factors that were significantly associated with birth asphyxia included mothers aged ≥ 35 [AOR=6.4, 95% CI (2.0, 20.5)], primigravida [AOR=5.1, 95% CI (2.0, 13.3)], prolonged second stage of labor [AOR=4.6, 95%CI (1.6, 13.3)], preterm birth [AOR=4.7, 95% CI (1.5, 14.1)], meconium stained amniotic fluid [AOR=7.5, 95% CI (2.5, 21.4)]and tight nuchal [AOR=3.1, 95% CI (1.2, 9.3)]. Conclusion: Birth asphyxia is still prevalent in the study setting. The results of this study show the need for better maternal care, creating awareness about contributing factors of birth asphyxia to the maternity health professionals, careful monitoring of labor, and identifying and taking proper measures that could help in reducing the occurrence of birth asphyxia.

show abstract

Evaluation of Pregnancy Outcomes at Advanced Maternal Age

Cited by 32 publications

References 23 publications

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

The Influence of Various Smoking Categories on The Risk of Gestational Hypertension and Pre-Eclampsia

Birth asphyxia and its contributing factors among the neonates delivered at Negest Eleni Mohammed memorial teaching hospital, Southern Ethiopia: A cross-sectional study

Contact Info

Product

Resources

About