Evaluation of Pre-radiotherapy Sleep Disorders in Patients With Rectal or Anal Cancer

Rades, Dirk; Kopelke, Svenja; Bartscht, Tobias; Schild, Steven E.; Tvilsted, Soeren; Kjær, Troels W.

doi:10.21873/anticanres.15251

Cited by 8 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the prevalence of sleep problems was not stated. In the present small study, the prevalence of sleep disorders prior to planned radiochemotherapy was 50.0%, which was higher than that prior to radiotherapy or radiochemotherapy for other malignancies such as gynecological cancers, prostate cancer, rectal cancer, lung cancer, and anal cancer (19)(20)(21)(22)(23).…”

Section: Discussioncontrasting

confidence: 62%

“…In a previous study of 62 patients with gynecological cancers, pre-radiotherapy sleep disturbances were significantly associated with greater numbers of physical problems, and a trend was found for greater numbers of emotional problems (19). Moreover, in a study of 42 patients with rectal or anal cancers, preradiotherapy sleep disturbances showed significant associations with higher distress scores and with greater numbers of physical problems or emotional problems (20). In a study of 48 patients scheduled for radiotherapy of prostate cancer, higher distress scores and greater numbers of physical problems were significantly associated with pre-radiotherapy sleep disturbances (21).…”

Section: Discussionmentioning

confidence: 85%

“…However, when considering the results of previous studies investigating risk factors for sleep disturbances prior to radiotherapy in patients with other pelvic malignancies, some consistency can be observed (19)(20)(21). In a previous study of 62 patients with gynecological cancers, pre-radiotherapy sleep disturbances were significantly associated with greater numbers of physical problems, and a trend was found for greater numbers of emotional problems (19).…”

Section: Discussionmentioning

confidence: 86%

See 2 more Smart Citations

Evaluation of Sleep Disturbances in Patients With Bladder Cancer Scheduled for Local or Loco-regional Radiochemotherapy

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background/Aim: Organ-sparing treatment is increasingly used for bladder cancer, particularly for patients with significant comorbidities or advanced age. The upcoming treatment can cause distress and sleep disturbances. This study investigated pre-radiotherapy sleep disturbances in these patients. Patients and Methods: Twenty-two patients with bladder cancer scheduled for local or loco-regional radiotherapy were retrospectively evaluated. Sixteen characteristics were analyzed for sleep disturbances including age, sex, performance score, comorbidities, previous malignancy, distress score, emotional problems, physical problems, treatment situation, treatment intent, current primary tumor and nodal stage, distant metastasis, treatment volume, concurrent chemotherapy, and Coronavirus Disease 2019 pandemic. Results: Eleven patients (50.0%) reported sleep disturbances that were significantly associated with distress scores ≥5 (p=0.035). Trends were found for age ≤75 years (p=0.183), ≥2 emotional problems (p=0.183), ≥5 physical problems (p=0.064), and distant metastasis (p=0.090). Conclusion: Half of the patients reported pre-radiotherapy sleep disturbances. Risk factors facilitate identification of patients requiring psychological support.When compared to other solid malignancies, cancers of the urinary bladder are comparably rare (1). Radical cystectomy is considered the standard approach in many institutions but can be associated with major complications including perioperative death (2-4). Therefore, bladder-sparing treatment approaches including radio-chemotherapy or radiotherapy and transurethral resection have become more popular, particularly for patients with significant comorbidities, worse performance status or advanced age (5-8). However, also multimodal bladder-sparing treatment can be quite burdensome for the patients, which may cause significant emotional distress associated with sleep disturbances. Moreover, to be scheduled for radiation therapy may aggravate the distress due to the fear of radiation exposure and high-tech machines. This idea is supported by a study performed in patients with breast or prostate cancer treated with local or loco-regional radiotherapy (9). In that study, the more pronounce sleep disturbances were reported by the patients before or during the initial phase of their course of radiotherapy. However, to our knowledge, no data have been reported so far regarding pre-treatment sleep disturbances in patients with bladder cancer assigned to a multimodal bladdersparing treatment approach. The present study aimed to provide data for this group of patients by evaluating the prevalence of sleep disturbances prior to a radio-chemotherapy course and potential risk factors for such sleep disturbances. These data will likely contribute to the identification of patients who need psycho-oncological support before the start of their radiochemotherapy treatment. Patients and MethodsTwenty-two patients with bladder cancer scheduled for local or loco-regional radiochemotherapy were retrospecti...

show abstract

Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Evaluation of Sleep Disturbances in Patients With Bladder Cancer Scheduled for Local or Loco-regional Radiochemotherapy

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Associations between higher distress scores and sleep problems prior to radiotherapy or radiochemotherapy were shown for patients with breast cancer, prostate cancer, and rectal or anal cancer (20,22,27). A trend for an association between pre-radiotherapy sleep problems and female gender was also reported for patients irradiated for rectal or anal cancer (27). However, since our present study can be considered unique, as it is the first study evaluating sleep problems prior to radiochemotherapy in patients with malignant gliomas, its results may not be directly compared to studies that included differing tumor types.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in the study investigating insomnia in patients with recurrent glial neoplasms, trends were observed for an association between insomnia and fatigue (physical problem) (11). Associations between higher distress scores and sleep problems prior to radiotherapy or radiochemotherapy were shown for patients with breast cancer, prostate cancer, and rectal or anal cancer (20,22,27). A trend for an association between pre-radiotherapy sleep problems and female gender was also reported for patients irradiated for rectal or anal cancer (27).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Sleep Problems Prior to Radiochemotherapy for Malignant Gliomas

Kopelke

Kjær

Tvilsted

et al. 2021

In Vivo

Self Cite

View full text Add to dashboard Cite

Background/Aim: Many patients with malignant gliomas are scheduled for radiochemotherapy, which may cause emotional distress associated with sleep problems. This study aimed to determine the prevalence of such sleep problems in these patients and identify risk factors. Patients and Methods: Fifty-seven patients scheduled for radiochemotherapy for grade II-IV gliomas were retrospectively investigated for pre-treatment sleep problems. Fifteen characteristics were evaluated including temporal relation to age, gender, performance status, comorbidity, (family) history of malignancies, distress score, emotional problems, physical problems, practical problems, involved sites, glioma grade, upfront surgery, and corticosteroids. Results: Nineteen patients stated pre-treatment sleep problems (prevalence=66.7%). Significant associations with sleep problems were found for female gender (p=0.023), presence of emotional problems (p=0.006), and ≥4 physical problems (p<0.001). A trend was found for distress scores ≥5 (p=0.077). Conclusion: The prevalence of sleep problems was high. Risk factors were determined that can be used to identify patients who likely benefit from psychological support.According to the classification of the World Health Organization (WHO), the group of gliomas includes four grades (grades I to IV), of which grade IV tumors (glioblastoma multiforme) are the most aggressive lesions with a 5-year survival rate of about 5% (1-3).Neurosurgical resection should be performed whenever safely possible. In patients with grade III or IV gliomas, resection is generally followed by radiochemotherapy (4-6). This applies also to selected patients with grade II gliomas, mainly after incomplete resection. Assignment to a course of radiochemotherapy may cause significant distress for the patients who may be afraid particularly of the exposure to radiation and potential treatment-related adverse events (7-10). The distress may lead to sleep problems that can significantly impair the patients' quality of life and require psychological support already prior to the start of radiochemotherapy (11)(12)(13). Therefore, the present study investigated the prevalence and potential risk factors of pre-treatment sleep problems in patients with grade II to IV gliomas assigned to radiochemotherapy. These data can contribute to the identification of patients who would likely benefit from psychological support beginning already prior to their course of radiochemotherapy. Patients and MethodsIn this retrospective study, 57 patients scheduled for radiochemotherapy of WHO grade II-IV gliomas were investigated with respect to pre-treatment sleep problems. These patients had completed the National Comprehensive Cancer Network (NCCN) Distress Thermometer (14,15) between February 2019 and March 2021. The study was approved as a part of a larger project by the Ethics Committee of the University of Lübeck (reference 21-284). The technique to be used for the planned radiotherapy was volumetricmodulated arc therapy (VMAT). The preferred dose-frac...

show abstract

Subgroups of sleep quality and associated risk factors in patients with cancer undergoing radiotherapy: A cross-sectional study based on latent profile analysis

Bi,

Zhang,

Wang

et al. 2024

European Journal of Oncology Nursing

View full text Add to dashboard Cite

Evaluation of Pre-radiotherapy Sleep Disorders in Patients With Rectal or Anal Cancer

Cited by 8 publications

References 15 publications

Evaluation of Sleep Disturbances in Patients With Bladder Cancer Scheduled for Local or Loco-regional Radiochemotherapy

Evaluation of Sleep Disturbances in Patients With Bladder Cancer Scheduled for Local or Loco-regional Radiochemotherapy

Risk Factors for Sleep Problems Prior to Radiochemotherapy for Malignant Gliomas

Subgroups of sleep quality and associated risk factors in patients with cancer undergoing radiotherapy: A cross-sectional study based on latent profile analysis

Contact Info

Product

Resources

About