Evaluation of powder mixtures and hydrophilic gastroretentive drug delivery systems containing zinc acetate and sodium bicarbonate

Mebeverine‐Loaded Electrospun Nanofibers: Physicochemical Characterization and Dissolution Studies

“…MB‐HCl has poor oral bioavailability; it suffers extensive first pass metabolism through the action of esterases in the blood plasma, and has a short half‐life in vivo . As a result of its method of action and in vivo degradation, traditional MB‐HCl formulations do not provide immediate relief of symptoms and typically show activity 2 h, but not 4 h, after administration . The development of DDSs able to provide very rapid or long‐lasting relief of symptoms is hence desirable.…”

Freeze-Dried Highly Porous Matrix as a New Gastroretentive Dosage Form for Ecabet Sodium: In Vitro and In Vivo Characterizations

“…Although the morphologies of FD‐GRT were affected by freezing temperature, both true density and porosity were not. GRT that were buoyant due to the generation of CO 2 usually require some lag time (>0.5 min) to float on the surface of the medium . The lag time could cause early escape of GRT from the stomach.…”

Gastro-retentive drug delivery technologies and their applications with cardiovascular medications

“…Fill an inflated chamber with a volatile liquid, like ether or cyclopentane, which volatilizes near body temperature, permitting the chamber to be inflated in the gut [32]. Various types of hydroxypropylmethylcellulose and alginate which are hydrophilic polymers frequently utilized as a matrix in noneffervescent systems because they allow for drug release control [60].…”