Evaluation of Potential Skin Sensitization of Humans Receiving Bright and Firm Hybrid Emulsion I

Abstract

In 2011, Bunman et al., 1 discovered and developed cream extraction from the head of fish cartilage. In 2015, this material has been added to silver sulfadiazine for accelerate and facilitate wound healing and to promote collagen synthesis. In 2016, Bunman et al., 2 studied liver and kidney toxicity in rats receiving cream extraction from fish cartilage. This result demonstrated that cream extracted from fish cartilage accelerated and facilitated wound healing without causing toxic effects to the liver and kidney in rats in long term use.In 2018, Bunman 3 formulated a new serum for facial wrinkle relief and to promote collagen synthesis. The study demonstrated that this serum has accelerated collagen synthesis and low potential skin sensitization in rat models. In 2019, Bunman developed and formulated a new cream for facial care, Bright and Firm Hybrid Emulsion I. Bright and Firm Hybrid Emulsion I is composed of many active ingredients to reduce wrinkles, to promote facial whitening and collagen synthesis. However, this product hasn't been investigated for potential skin sensitization in humans.The aim of this study is to evaluate potential skin sensitization of applied Bright and Firm Hybrid Emulsion I using modified HRIPT.