Evaluation of potential prebiotics: a review

Bajury, Dayang Marshitah; Nashri, Siti Maisarah; King, Patricia Jie Hung; Sarbini, Shahrul Razid

doi:10.1080/87559129.2017.1373287

Cited by 21 publications

(14 citation statements)

References 121 publications

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“…Fructans and galactans are examples of popular prebiotics with several research investigations highlighting their effect in enriching beneficial gut bacteria such as Lactobacillus and/or Bifidobacterium spp. (Bajury et al, 2017). With advances in microbiome research, our understanding of gut microbiota composition and substances that modify the microbiota has improved.…”

Section: Introductionmentioning

confidence: 99%

Review of Antibiotic Resistance, Ecology, Dissemination, and Mitigation in U.S. Broiler Poultry Systems

et al. 2019

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Since the onset of land application of poultry litter, transportation of microorganisms, antibiotics, and disinfectants to new locations has occurred. While some studies provide evidence that antimicrobial resistance (AMR), an evolutionary phenomenon, could be influenced by animal production systems, other research suggests AMR originates in the environment from non-anthropogenic sources. In addition, AMR impacts the effective prevention and treatment of poultry illnesses and is increasingly a threat to global public health. Therefore, there is a need to understand the dissemination of AMR genes to the environment, particularly those directly relevant to animal health using the One Health Approach. This review focuses on the potential movement of resistance genes to the soil via land application of poultry litter. Additionally, we highlight impacts of AMR on microbial ecology and explore hypotheses explaining gene movement pathways from U.S. broiler operations to the environment. Current approaches for decreasing antibiotic use in U.S. poultry operations are also described in this review.

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Section: Introductionmentioning

confidence: 99%

Review of Antibiotic Resistance, Ecology, Dissemination, and Mitigation in U.S. Broiler Poultry Systems

et al. 2019

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“…This may explain why in some cases the experiments may have failed in the identification of the most suited strains for a given target population. The use of fecal culture models, or intestinal simulators, has been also common in the search for prebiotics with microbiota modulating abilities ( Roberfroid et al, 2010 ; Shen et al, 2011 ; Bajury et al, 2018 ; Nogacka et al, 2020b ). However, such models have not been so extensively used in probiotics research.…”

Section: Discussionmentioning

confidence: 99%

In vitro Selection of Probiotics for Microbiota Modulation in Normal-Weight and Severely Obese Individuals: Focus on Gas Production and Interaction With Intestinal Epithelial Cells

et al. 2021

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The intestinal microbiota plays important roles in the maintenance of health. Strategies aiming at its modulation, such as probiotics, have received a deal of attention. Several strains have been studied in different in vitro models; however, the correlation of results obtained with the in vivo data has been limited. This questions the usefulness of such in vitro selection models, traditionally relying on over-simplified tests, not considering the influence of the accompanying microbiota or focusing on microbiota composition without considering functional traits. Here we assess the potential of six Bifidobacterium, Lactobacillus and Lacticaseibacillus strains in an in vitro model to determine their impact on the microbiota not just in terms of composition but also of functionality. Moreover, we compared the responses obtained in two different population groups: normal-weight and severely obese subjects. Fecal cultures were conducted to evaluate the impact of the strains on specific intestinal microbial groups, on the production of short-chain fatty acids, and on two functional responses: the production of gas and the interaction with human intestinal epithelial cells. The response to the different probiotics differed between both human groups. The addition of the probiotic strains did not induce major changes on the microbiota composition, with significant increases detected almost exclusively for the species added. Higher levels of gas production were observed in cultures from normal-weight subjects than in the obese population, with some strains being able to significantly reduce gas production in the latter group. Moreover, in obese subjects all the Bifidobacterium strains tested and Lacticaseibacillus rhamnosus GG were able to modify the response of the intestinal cells, restoring values similar to those obtained with the microbiotas of normal-weight subjects. Our results underline the need for the screening and selection of probiotics in a target-population specific manner by using appropriate in vitro models before enrolling in clinical intervention trials.

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“…Prebiotics are recognised for their ability to manipulate host microbiota to the benefit of the host (Gibson et al ., ). Currently fructans (Ahmad & Khalid, ; Bajury et al ., ; Joshi et al ., ), inulin (Ahmadi et al ., ; Fu et al ., ; Heydari et al ., ) and galactans (Cremon et al ., ; Fehlbaum et al ., ; Ndeh & Gilbert, ), fit this definition of prebiotics. Prebiotic products have a strong science background from positive clinical trials but have yet to obtain regulator‐approved health claims from the European Food Safety Authority (EFSA) in Europe.…”

Section: Prebioticsmentioning

confidence: 97%

Ensuring the future of functional foods

Birch

Bonwick

2018

Int J of Food Sci Tech

125

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Consumption of functional foods suggests a strategy to reduce the incidence of chronic health disorders. This message has resonated with consumers and driven market growth. Functional food research has significantly increased over the last decade but few studies have addressed the bioavailability of active ingredients for clinical efficacy. Baked goods such as bread, biscuits and cake are popular categories for innovation due to their widespread consumption. These new developments have often impacted on organoleptic properties of the finished products and thus consumer acceptance. Blending of bioactive ingredients may overcome this deficit. However, an understanding of the role of the microbiome in health has indicated that the efficacy of functional foods is unlikely to be uniform within the population. Further growth in the functional foods market, is likely to require greater evidence of the bioavailability of active ingredients, clinical effect and support for health claims by regulators especially in the EU.

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Evaluation of potential prebiotics: a review

Cited by 21 publications

References 121 publications

Review of Antibiotic Resistance, Ecology, Dissemination, and Mitigation in U.S. Broiler Poultry Systems

Review of Antibiotic Resistance, Ecology, Dissemination, and Mitigation in U.S. Broiler Poultry Systems

In vitro Selection of Probiotics for Microbiota Modulation in Normal-Weight and Severely Obese Individuals: Focus on Gas Production and Interaction With Intestinal Epithelial Cells

Ensuring the future of functional foods

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