Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs

Zhang, Yufeng; Lyu, Chunming; Fong, Sophia Yui Kau; Wang, Qian; Li, Chenrui; Ho, Nicolas James; Chan, Kay Sheung; Yan, Xiaoyu; Zuo, Zhong

doi:10.1016/j.jep.2019.112097

Cited by 20 publications

(12 citation statements)

References 25 publications

(25 reference statements)

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“…Recently, natural products have been paid more and more attentions because of their wide sources, pharmacological activities, low costs, and minimal side effects [ 32 ]. Most of the research studies have focused on the analysis of the species of natural products and their active components [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Han

Guo

Meng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Introduction. Forsythin is the main ingredient of Forsythia suspensa and is widely used in treatment of fever, viral cold, gonorrhea, and ulcers clinically. This study aimed to evaluate the potential genetic toxicity of forsythin and its safety for human use. Methods. Based on the Good Laboratory Practice regulations and test guidelines, the genetic toxicity of forsythin was assessed by the Ames test, chromosome aberration (CA) test, and bone marrow micronucleus (MN) test in vivo. In the Ames test, five strains of Salmonella typhimurium were exposed to different concentrations of forsythin in the presence or absence of the S9 mixture, and then, the number of His + revertant colonies was counted. In the CA test, Chinese hamster lung (CHL) fibroblast cells were treated with different concentrations of forsythin, mitomycin C, or cyclophosphamide in the presence or absence of the S9 mixture, and the chromosomal aberrations were determined. In the MN test, bone marrow was isolated from the mice with different treatments, and the ratios of polychromatic erythrocytes (PCE) and erythrocytes (PCE/(PCE + NCE)) were measured. Finally, beagle dogs were divided into four groups (negative control, low dose, medium dose, and high dose groups), and then, a telemetry system was used to evaluate the safe use of forsythin. Results. Ames test results showed that the number of colonies in all test strains with different treatments showed no significantly dose-dependent increase in the presence or absence of the S9 mixture ( p > 0.05 ). In the CA test, the number of cells with aberrations in the CHL fibroblast cells treated with low, medium, and high doses of forsythin for 24/48 h in the absence of the S9 mixture was, respectively, 5.0/2.5, 4.5/1.5, and 5.0/5.0, and in the presence of the S9 mixture, the number was, respectively, 5.0, 5.0, and 4.5. These results showed that there was no significant difference compared to the negative control group either in the presence (2.0) or in the absence (4.0/2.5 for 24/48 h) of the S9 mixture ( p > 0.05 ). The MN test showed that the values of PCE/(PCE + NCE) in the negative, positive controls, and forsythin treatment groups were all more than 20%, which indicated that forsythin had no cytotoxicity. Additionally, no significant toxicological effects of forsythin on blood pressure, respiration, temperature, electrocardiogram, and other physiological indicators in the conscious beagle dogs of different groups were observed by the telemetry method. Conclusion. Our findings showed that forsythin has low probability of genetic toxicity and no significant toxicological effects, which implied that forsythin is suitable for further development and potential application.

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Section: Discussionmentioning

confidence: 99%

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Han

Guo

Meng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…No one can guarantee that traditional Chinese medicine will not make some breakthroughs in these unsolved fields, similar to Tu [ 59 ]. The potential utility of Chinese herbs in clinical practice in the future includes replacing or reducing the use of antibiotics [ 60 , 61 ], reducing the overuse of hormone drugs [ 62 ], antivirus activity [ 63 ], antitumor activity [ 64 ], improving immunity [ 65 ], and others. After all, humans know too little about the world.…”

Section: Discussionmentioning

confidence: 99%

Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example

Sun

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Pneumonia is a serious global health problem and the leading cause of mortality in children. Antibiotics are the main treatment for bacterial pneumonia, but there are serious drug resistance problems. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and has a unique theory. This article takes the treatment of pneumonia with Ephedra sinica as a representative hot medicine and Scutellariae Radix as a representative cold medicine as an example. We explore and explain the theory of treating the same disease with different TCM treatments. Using transcriptomics and network pharmacology methods, GO, KEGG enrichment, and PPI network construction were carried out, demonstrating that Ephedra sinica plays a therapeutic role through the NF-κB and apoptosis signaling pathways targeting PLAU, CD40LG, BLC2L1, CASP7, and CXCL8. The targets of Scutellariae Radix through the IL-17 signaling pathway are MMP9, CXCL8, and MAPK14. Molecular docking technology was also used to verify the results. In short, our results provide evidence for the theory of treating the same disease with different treatments, and we also discuss future directions for traditional Chinese medicine.

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“…MDCK cells are susceptible to multiple influenza virus strains, supporting numerous passages of virus replication (capable of 35 consecutive rounds), and are widely used in antiviral activity assessment, mechanism research, and influenza vaccine development. MDCK cells are the most widely used cell lines for antiviral research in TCM [ 27 – 29 ]. Single herb such as Scutellariae Radix (黄芩) [ 30 ], Isatidis Radix (板蓝根) [ 31 ], Lonicerae Japonicae Flos (金银花) [ 32 ], Houttuyniae Herba (鱼腥草) [ 32 ], etc.…”

Section: Experimental Modelsmentioning

confidence: 99%

Anti-COVID-19 drug screening: Frontier concepts and core technologies

et al. 2020

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The outbreak of COVID-19 has recently evolved into a global pandemic. Up to July 2020, almost every country has confirmed COVID-19 cases reported worldwide. Many leading experts have predicted that the epidemic will persist for relatively a long period of time. Thus far, there have been no remedies proven effective against the disease. As the nation where COVID-19 broke out first, China has adopted a combination of traditional Chinese medicine and western medicine to fight against the disease, and has achieved significant clinical result. Up to now, the COVID-19 pandemic has been effectively controlled in China. However, the rest of the world (except for a limited number of countries and regions) is still in deep water. This paper thoroughly summarizes interdisciplinary notions and techniques, including disease model, biochip, network pharmacology, and molecular docking technology, etc., providing a reference for researchers in the screening of drugs for COVID-19 prevention and treatment. These methodologies may facilitate researchers to screen out more potential drugs for treating COVID-19 pneumonia and to tackle this global crisis.

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Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs

Cited by 20 publications

References 25 publications

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example

Anti-COVID-19 drug screening: Frontier concepts and core technologies

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