Evaluation of Potential Drug–Drug Interactions in Adults in the Intensive Care Unit: A Systematic Review and Meta-Analysis

Fitzmaurice, Mary Grace; Wong, Adrian; Akerberg, Hannah; Avramovska, Simona; Smithburger, Pamela L.; Buckley, Mitchell S.; Kane‐Gill, Sandra L.

doi:10.1007/s40264-019-00829-y

Cited by 49 publications

(54 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Using the techniques of improving relevance, soliciting feedback, customization, measurement of outcomes and metrics, and iteration, the effects of CDS on burnout can be ameliorated. [20,24,97] -Role tailoring of alerts [21,82] -Tiering of alerts [20,80] -Iterative design [25] Harmful -Interruptive or hard stop alerts [21,25,80] -Lack of "right information" [18] -Lack of relevance [80,97,108] -Lack of integration [78]…”

Section: Resultsmentioning

confidence: 99%

Clinical Decision Support and Implications for the Clinician Burnout Crisis

Janković

Chen

2020

Yearb Med Inform

View full text Add to dashboard Cite

Objectives: This survey aimed to review aspects of clinical decision support (CDS) that contribute to burnout and identify key themes for improving the acceptability of CDS to clinicians, with the goal of decreasing said burnout. Methods: We performed a survey of relevant articles from 2018-2019 addressing CDS and aspects of clinician burnout from PubMed and Web of Science™. Themes were manually extracted from publications that met inclusion criteria. Results: Eighty-nine articles met inclusion criteria, including 12 review articles. Review articles were either prescriptive, describing how CDS should work, or analytic, describing how current CDS tools are deployed. The non-review articles largely demonstrated poor relevance and acceptability of current tools, and few studies showed benefits in terms of efficiency or patient outcomes from implemented CDS. Encouragingly, multiple studies highlighted steps that succeeded in improving both acceptability and relevance of CDS. Conclusions: CDS can contribute to clinician frustration and burnout. Using the techniques of improving relevance, soliciting feedback, customization, measurement of outcomes and metrics, and iteration, the effects of CDS on burnout can be ameliorated.

show abstract

Section: Resultsmentioning

confidence: 99%

Clinical Decision Support and Implications for the Clinician Burnout Crisis

Janković

Chen

2020

Yearb Med Inform

View full text Add to dashboard Cite

show abstract

“…We read with interest the systematic review and meta-analysis by Fitzmaurice et al published in the May 2019 issue of Drug Safety [1]. The clinical significance of drug-drug interactions is a significantly important yet understudied domain and the authors have made a notable contribution in this area.…”

Section: Dear Editormentioning

confidence: 99%

Comment on “Evaluation of Potential Drug–Drug Interactions in Adults in the Intensive Care Unit: A Systematic Review and Meta-analysis”

et al. 2020

View full text Add to dashboard Cite

“…Laut einer aktuellen Metaanalyse lässt sich bei 58 % aller Intensivpatienten mindestens eine potenzielle Arzneimittelinteraktion detektieren, wobei diese bei jedem 6. betroffenen Patienten relevant verläuft. Umgekehrt lässt sich zeigen, dass je nach Einzeluntersuchung 7-44 % der klinisch relevanten unerwünschten Arzneimittelwirkungen interaktionsbedingt sind [5]. Kenntnisse wichtiger Wechselwirkungen sind für den Intensivmediziner daher für die Therapiesicherheit von großer Bedeutung.…”

Section: Definition Und Häufigkeitunclassified

Arzneimittelinteraktionen in der Intensivmedizin

Drust¹

2020

Intensivmedizin up2date

View full text Add to dashboard Cite

ZusammenfassungArzneimittelinteraktionen sind auf Intensivstationen ein häufiges Problem. Dabei spielt die Gesamtmenge der verschriebenen Medikamente bei kritisch kranken Patienten eine große Rolle: Durchschnittlich werden hier 25 – 35 Medikamente pro Patient eingesetzt. Fundierte Kenntnisse über entsprechende pharmakodynamische und pharmakokinetische Mechanismen sind für die Behandlungssicherheit daher essenziell.

show abstract

Evaluation of Potential Drug–Drug Interactions in Adults in the Intensive Care Unit: A Systematic Review and Meta-Analysis

Cited by 49 publications

References 52 publications

Clinical Decision Support and Implications for the Clinician Burnout Crisis

Clinical Decision Support and Implications for the Clinician Burnout Crisis

Comment on “Evaluation of Potential Drug–Drug Interactions in Adults in the Intensive Care Unit: A Systematic Review and Meta-analysis”

Arzneimittelinteraktionen in der Intensivmedizin

Contact Info

Product

Resources

About