Evaluation of postoperative complications after mandibular third molar surgery with the use of platelet-rich fibrin: a systematic review and meta-analysis

Canellas, João Vitor dos Santos; Ritto, Fabio; Medeiros, Paulo José

doi:10.1016/j.ijom.2017.04.006

Cited by 57 publications

(53 citation statements)

References 35 publications

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“…The results of this metaanalysis showed a positive effect of PRF on postoperative pain confirming the results of other recents systematic reviews. 72,73 Our results supported that PRF was more effective to reduce swelling in the third day although only 3 studies have been included and it demands more studies to confirm the real effect. In the bone healing evaluation, the qualitative analysis observed a favorable effect of PRF on hard tissue cicatrization, similarly to other systematic reviews that evaluated platelets concentrates.…”

Section: Discussionsupporting

confidence: 58%

“…A total of 8 types of surgical interventions routinely performed in oral and maxillofacial surgery were analyzed in this systematic review. Currently, the use of PRF in mandibular third molar surgery has been broadly studied, and 3 recents systematic reviews [71][72][73] showed a beneficial effect of PRF on preventing dry sockets within the first 7 days. However, the study of He et al 73 included 1 article 49 that presented 2 cases of infection after surgery (3 weeks and 2 months), that should not have been included in the meta-analysis to evaluate AO.…”

Section: Discussionmentioning

confidence: 99%

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Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

Canellas

Medeiros

Figueredo

et al. 2019

International Journal of Oral and Maxillofacial Surgery

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The effect of platelet-rich fibrin (PRF) in enhancing the healing after oral surgical interventions is still a matter of debate. The purpose of this study was to identify instances where PRF has been shown to be effective in oral surgical procedures. A comprehensive literature search was performed up to 2017 on PubMed/MEDLINE, Cochrane Library, Web of Science, Scopus and LILACS databases and grey literature. The full-text of potentially relevant studies were reviewed and only randomized clinical trials (RCTs) were included. A total of 559 studies were found, of which 30 were included for qualitative analysis and 13 for quantitative analysis. Three review authors assessed the risk of bias independently. The available literature suggests that PRF has a positive effect in improving alveolar preservation on extraction sockets and around dental implants. The qualitative analysis showed a significantly better effect of PRF in promoting bone regeneration for alveolar cleft reconstruction. The meta-analysis for third molar surgery showed a decrease in prevalence of alveolar osteitis. PRF increased implant stability 1 week and 1 month after surgery (P=0.0005 and 0.0003). Due to the lack of studies with low risk of bias and a limited number of patients available, further RCTs are needed to confirm these results.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

Canellas

Medeiros

Figueredo

et al. 2019

International Journal of Oral and Maxillofacial Surgery

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“…At the same time, Castro et al provided systematic reviews on alveolar ridge preservation, sinus floor elevation and implant therapy (Castro et al, 2017b) as well as intrabony defects, furcation defects, and periodontal plastic surgery (Castro et al, 2017a). Also, systematic reviews on mandibular third molar extractions (Al-Hamed, Tawfik, Abdelfadil, & Al-Saleh, 2017;Canellas, Ritto, & Medeiros, 2017) and gingival recessions (Moraschini & Barboza Edos, 2016) became available. This study is complementary to these current systematic reviews.…”

Section: Introductionmentioning

confidence: 99%

The use of platelet‐rich fibrin to enhance the outcomes of implant therapy: A systematic review

Strauß

Stähli

Gruber

2018

Clinical Oral Implants Res

102

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ObjectiveTo assess the impact of platelet‐rich fibrin (PRF) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of PRF administration for bone regeneration and implant therapy?MethodA systematic literature search comprised three databases: MEDLINE, EMBASE, and Cochrane followed by a hand search of relevant scientific journals. Human studies using PRF for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included. Eligible studies were selected based on the inclusion criteria. Randomized controlled trials (RCT) and controlled clinical trials (CCT) were included.ResultsIn total, 5,963 titles were identified with the search terms and by hand search. A total of 12 randomized controlled trials (RCT) met the inclusion criteria and were chosen for data extraction. Included studies focused on alveolar ridge preservation after tooth extraction, osseointegration process, soft tissue management, bone augmentation, bone regeneration after sinus floor elevation and surgical peri‐implantitis treatment. Overall, the risk of bias was moderate or unclear. Nine studies showed superior outcomes for PRF for any of the evaluated variables, such as ridge dimension, bone regeneration, osseointegration process, soft tissue healing. Three studies failed to show any beneficial effects of PRF. No meta‐analysis could be performed due to the heterogeneity of study designs.ConclusionsThere is moderate evidence supporting the clinical benefit of PRF on ridge preservation and in the early phase of osseointegration. It remains unclear whether PRF can reduce pain and improve soft tissue healing. More research support is necessary to comment on the role of PRF to improve other implant therapy outcomes.

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“…The increasing interest in understanding the effects of platelet concentrate application on bone tissue is reflected in the number of recent studies that have examined this topic (Al‐Hamed et al, ; Canellas et al, ; Cortese et al, ; Isobe et al, ; Panda et al, ). Although there have been studies that have used models of bone lesions in animals to clarify the effects of these platelet concentrates at different levels (Acar et al, ; Bölükbaşı, Yeniyolm, Tekkesinm, & Altunatmaz, ; Du et al, ; Ocak et al, ), there are also clinical studies that focus on radiological (Cortese et al, ; Park et al, ) and tomographic analyses (Lim et al, ; Montanari, Callea, Yavuz, & Maglione, ; Öncü & Kaymaz, ) and its use in clinical settings (Barone et al, ; Panda et al, ; Sezgin, Uraz, Taner, & Çulhaoğlu, ), all of which seek to evaluate the effects of this therapy.…”

Section: Discussionmentioning

confidence: 99%

“…PRF is a second‐generation platelet concentrate developed by Choukroun et al () in France. This biomaterial is autologous in clinical applications (Canellas, Ritto, & Medeiros, ; Du et al, ; Öncü & Kaymaz, ) and is produced from immediate blood centrifugation without the addition of an anticoagulant or gelling agent (Al‐Hamed, Tawfik, Abdelfadil, & Al‐Saleh, ; Canellas et al, ; Isobe et al, ).…”

Section: Introductionmentioning

confidence: 99%

Platelet‐rich fibrin and collagen membrane in the preservation of the alveolar bone: Feasibility of the elemental inorganic composition and scanning electron microscopy analysis

Días

Arias

Borie

et al. 2019

Microscopy Res & Technique

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The success of dental implants is related to the amount, quality, and composition of the alveolar bone. The placement of platelet-rich fibrin (PRF) clot associated with a resorbable collagen membrane (RCM) in a postextraction alveolus is a technique used for ridge preservation. This case report study analyzed the ultrastructural characteristics of cross-sectioned alveolar bone that received PRF and RCM using scanning electron microscopy and the inorganic composition using "energy dispersive X-ray spectrometry," in order to explore the feasibility of this method to clinical studies.Three alveolar bone samples from two male patients (37 and 58 years old), obtained in the procedure of placing the dental implant, were analyzed. Two bone samples previously received PRF and RCM (M37 and M58), the third sample represented a physiological bone formation without treatment (M37-control). The bone sample M37 showed irregularly shaped islets of calcified material intermingled with connective tissue. The other samples, from the 58-year-old patient with PRF and RCM (M58); and the other untreated bone sample from the same 37-year-old patient (M37-control) showed similar ultrastructural morphology with trabecular conformation without islets agglomerations. The inorganic composition analysis showed higher concentrations of calcium and phosphorus in both samples treated with PRF and RCM in comparison to the untreated bone sample. The Ca/P ratio was higher in the M37 sample compared to the others samples. The results showed morphology and inorganic composition differences among the treatments used, suggesting that this method is feasible to analyze parameters of the alveolar bone tissue.

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Evaluation of postoperative complications after mandibular third molar surgery with the use of platelet-rich fibrin: a systematic review and meta-analysis

Cited by 57 publications

References 35 publications

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

The use of platelet‐rich fibrin to enhance the outcomes of implant therapy: A systematic review

Platelet‐rich fibrin and collagen membrane in the preservation of the alveolar bone: Feasibility of the elemental inorganic composition and scanning electron microscopy analysis

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