Evaluation of Post Wide Excision Non-Melanoma Skin Cancer at DR Cipto Mangunkusumo Hospital in 2012-2015: Recurrence and Prognostic Factors

Abstract

Introduction.Skin cancer is one of many kinds of cancer which incidence increases globally. Basal cell carcinoma (BSC) and squamous cell carcinoma (SCC) are the most common prevalence of non-melanoma skin cancer, and also are the most common cancer among skin cancer. The main therapy for such skin cancer is wide excision within its safety margin added by adjuvant therapy. Despite adequate therapy, people with skin cancer still have a risk of recurrence. This study assesses the prognostic factors of recurrence among people with non-melanoma skin cancer who underwent wide excision surgery. Method. This study was a retrospective cohort with survival analysis. The patient's data who underwent wide excision surgery were from Perhimpunan Ahli Bedah Onkologi Indonesia (PERABOI) registry and medical record from Oncology Surgery Division in RSCM from January 2012-December 2015. Data selection was done based on inclusion and exclusion criteria. Results. There were 187 patients with non-melanoma skin cancer who underwent wide excision surgery; the recurrence was detected on 15% of the case. Most of the patients were ≥45 years old with the most common histopathological feature of the skin cancer was basal cell carcinoma. We did a survival analysis with Cox regression and the result was previous history of skin cancer (RR 6.903; 95% CI 2.925-16.292), perineural invasion (HR 3.818; 95% CI 1.561-9.340), location of the lesion (HR 0.071; 95% CI 0.022-0.228), and size of the tumor (HR 1.842; 95% CI 1.244-2.729) was the factors that increased recurrence. Conclusion. History of previous skin cancer, perineural invasion, location of the lesion, and size of the tumor were the prognostic factors for recurrence among patients with non-melanoma skin cancer who underwent wide excision surgery.

Wide excision of Basal Cell Carcinoma on the upper extremity: A case report

“…It is characterized by a constantly increasing incidence in the population older than 60 years old, and because of widespread sun exposure (Fania et al, 2020;Toha et al, 2019) The most aff ected locations are head and neck. However, other locations, such as trunk, upper, and lower extremities could also be aff ected (Pratama & Kurnia, 2019) Research by Hooshang et al (2017) mentioned that only 3.85% of 650 patients had BCC on the upper extremity and trunk. This might be due to culture and/or clothing style (Hooshang et al, 2017).…”