Evaluation of possible role of the hTERT gene rs2853669 polymorphism in the development of colorectal cancer as a genetic risk factor

Kaya, Berrin Yalınbaş; Ülger, Yakup

doi:10.1080/15257770.2022.2086694

Cited by 1 publication

(2 citation statements)

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“…Studies have presented that SNPs in hTERT gene are closely related to an increased risk of cancers (Leao et al 2018). In studies conducted in the Turkish population, hTERT gene rs2853669 and rs2736098 polymorphisms are investigated in CRC, and negative correlations are detected between rs2853669 and rs2736098 polymorphisms and CRC susceptibility (Jannuzzi et al 2015, Yalinbas Kaya andUlger 2022). Currently, our study is the first to investigate the association of hTERT gene rs2853669 and rs2736098 polymorphisms with CRC susceptibility in the Chinese Han population.…”

Section: Discussionmentioning

confidence: 76%

“…Rs2853669 (−245T > C) and rs2736098 are two common functional SNPs in the promoter region of hTERT gene, they can influence the telomerase activity and telomere length (Oztas et al 2016). In previous studies, hTERT gene rs2853669 and rs2736098 polymorphisms are detected in multiple tumors, such as gastric cancer, melanoma, hepatocellular carcinoma and so on (Bayram et al 2016, Yalinbas Kaya and Ulger 2022. In terms of CRC, the genetic association of hTERT…”

Section: Introductionmentioning

confidence: 99%

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Association of hTERT Gene Polymorphism and Colorectal Cancer (CRC) Risk in the Chinese Han Population

Fu,

Xiong,

Tang

et al. 2024

Tohoku J. Exp. Med.

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The catalytic subunit telomerase reverse transcriptase (hTERT) is a prerequisite for malignant transformation of human cells. Colorectal cancer (CRC) is a common malignant tumor. The genetic association of hTERT gene rs2853669 and rs2736098 polymorphisms with CRC was surveyed in the Chinese population. 200 patients with CRC and 200 healthy controls were taken for blood sample collection. Sanger sequencing was applied for genotyping. Multiple logistic regression analysis was performed and odds ratio (OR) together with confidence interval (CI) were calculated to obtain the corresponding association power. Among CRC cases (49.50%), hTERT gene rs2736098 GA genotype carriers were more prevalent compared with the control group (41.00%, P = 0.035), which increased the risk of CRC by 1.576 times (95% CI = 1.031-2.409). Distribution of the rs2736098 genotypes was significantly associated with TNM stage, tumor differentiation, tumor size and lymph node metastasis (P < 0.05). The frequencies of hTERT gene rs2853669 polymorphism were not significantly different between CRC patients and healthy controls. Logistic regression analysis indicated that both BMI and hTERT gene rs2736098 polymorphism remained significantly correlated with CRC susceptibility. The frequencies of hTERT gene rs2853669 polymorphism did not differ significantly between CRC patients and control group (P > 0.05). The hTERT gene rs2736098 polymorphism was correlated with CRC risk in the Chinese Han population, and the GA genotype was a risk element for the onset of CRC.

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Section: Discussionmentioning

confidence: 76%