Evaluation of possible molecular toxicity induced by occupational exposure to lead and concomitant effect of smoking

Fouad, Azza Ali; Foda, Nermine Tawfik; Diab, Iman; Dine, Fatma Mohamed Magdy Badr El; Balah, Manal Ibrahim Fathy

doi:10.1007/s11356-019-06879-0

Cited by 10 publications

(5 citation statements)

References 37 publications

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“…Previous studies have shown that most organic solvents have chronic toxic effects, among which benzene is a known carcinogen in humans ( 29 , 30 ). Regarding lead poisoning, it has been demonstrated that lead, as a cumulative toxicant, has detrimental effects on different organ systems, even in low doses ( 31 , 32 ). In particular, benzene is a common and major toxicant in occupational poisoning in Zhejiang Province, and benzene poisoning in chronic poisoning still needs to be paid attention to.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of occupational chemical poisonings in Zhejiang, China from 2006 to 2020: A descriptive analysis

Zhou

Wei

Fang

et al. 2022

Front. Public Health

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ObjectiveAs the second most common occupational disease in China, occupational poisoning is one of the major public health problems that seriously affect workers' health. This study aimed to investigate the epidemiological and occupational characteristics of acute and chronic occupational poisoning cases in Zhejiang Province, so as to provide a scientific basis for proposing intervention measures and preventive strategies of occupational poisoning.MethodsThe data on occupational poisoning cases in Zhejiang Province from 2006 to 2020 was derived from the National Occupational Disease Network Direct Report System. A descriptive statistical analysis was employed on this data utilizing R software.ResultsFrom 2006 to 2020, 1,008 occupational poisoning cases were reported in Zhejiang Province, with a downward trend since 2007. Of these cases, 81.94% were chronic poisoning and 18.06% were acute poisoning. Ningbo reported the most occupational poisoning cases among the 11 cities in Zhejiang Province, accounting for 20.34% of the total cases. Besides, the occupational poisoning cases in Wenzhou, Jiaxing, and Shaoxing also accounted for 18.15%, 18.06%, and 17.76% of the total number of cases, respectively. Occupational poisoning in male were 693 cases and in female 315 cases. Most of the occupational poisoning cases studied involved people aged between 40 and 49 years (38.19%). The length of work in chronic occupational poisoning cases was significantly higher than that of acute occupational poisoning cases (P < 0.05). Benzene and lead and its compounds (excluding tetraethyl lead) were the major toxicants causing occupational poisoning. More than 60% of occupational poisoning cases were reported in private enterprises. Meanwhile, over 90% of the cases were distributed in medium enterprises and small enterprises. The type of industry with the most occupational poisoning cases was the manufacturing industry.ConclusionAlthough the cases of occupational poisoning in Zhejiang Province have declined, more comprehensive and effective prevention and control measures are still needed. More attention ought to be paid to the management of key points according to the epidemiological and occupational characteristics of occupational poisoning cases.

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Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of occupational chemical poisonings in Zhejiang, China from 2006 to 2020: A descriptive analysis

Zhou

Wei

Fang

et al. 2022

Front. Public Health

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“…42 A recent study showed that lead-exposed workers who smoked presented slightly higher BLLs compared to exposed non-smokers. 43 Hence, the use of tobacco can influence the risk of high BLLs.…”

Section: Discussionmentioning

confidence: 99%

Influence ofVDRandHFEpolymorphisms on blood lead levels of occupationally exposed workers

et al. 2020

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Lead is a ubiquitous heavy metal toxin of significant public health concern. Every individual varies in their response to lead’s toxic effects due to underlying genetic variations in lead metabolizing enzymes or proteins distributed in the population. Earlier studies, including our lab, have attributed the influence of ALAD (δ-Aminolevulinate dehydratase) polymorphism on blood lead retention and ALAD activity. The present study aimed to investigate the influence of VDR (Vitamin D receptor) and HFE (Hemochromatosis) polymorphisms in modulating blood lead levels (BLLs) of occupationally exposed workers. 164 lead-exposed subjects involved in lead alloy manufacturing and battery breaking and recycling processes and 160 unexposed controls with BLLs below 10 µg/dL recruited in the study. Blood lead levels, along with a battery of biochemical assays and genotyping, were performed. Regression analysis revealed a negative influence of BLLs on ALAD activity ( p < 0.0001) and a positive influence on smokeless tobacco use ( p < 0.001) in lead-exposed subjects. A predicted haplotype of the three VDR polymorphisms computed from genotyping data revealed that T-A-A haplotype increased the BLLs by 0.93 units ( p ≤ 0.05) and C-C-A haplotype decreased the BLLs by 7.25 units ( p ≤ 0.05). Further analysis revealed that the wild-type CC genotype of HFE H63D presented a higher median BLL, indicating that variant C allele may have a role in increasing the concentration of lead. Hence, the polymorphism of genes associated with lead metabolism might aid in predicting genetic predisposition to lead and its associated effects.

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“…Tobacco contains many harmful compounds, such as nicotine, nitrous oxide, cadmium, ethanol, etc., that may react with biological macromolecules and increase free radicals formation. Many reports show that smoking induces oxidative stress in humans [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation

et al. 2020

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The purpose of this study was to evaluate the relationship between blood redox status, dose and antioxidant dietary intake of different hospital staff groups exposed to low doses of ionizing radiation (LDIR) (Interventional Radiology and Cardiology, Radiation Oncology, and Nuclear Medicine) and non-exposed. Personal dose equivalent (from last year and cumulative), plasma antioxidant markers (total antioxidant capacity, extracellular superoxide dismutase activity, and glutathione/oxidized glutathione ratio), oxidative stress markers (nitrites and nitrates, and lipid peroxidation) and dietary intake (antioxidant capacity using ORAC values) were collected and analyzed from 28 non-exposed healthcare workers and 42 healthcare workers exposed to LDIR. Hospital staff exposed to LDIR presented a redox imbalance in blood that seems to correlate with dose. Workers from the Nuclear Medicine Unit were the most affected group with the lowest value of plasma antioxidant response and the highest value of plasma thiobarbituric acid reactive substances, TBARS (indicator of lipid peroxidation) of all four groups. Cumulative personal dose equivalent positively correlated with nitrites and negatively correlated with total antioxidant capacity in blood. The diet of healthcare workers from Nuclear Medicine Unit had higher ORAC values than the diet of non-exposed. Therefore, occupational exposure to LDIR, especially for the Nuclear Medicine Unit, seems to produce an imbalanced redox status in blood that would correlate with cumulative personal dose equivalent.

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Evaluation of possible molecular toxicity induced by occupational exposure to lead and concomitant effect of smoking

Cited by 10 publications

References 37 publications

Epidemiological characteristics of occupational chemical poisonings in Zhejiang, China from 2006 to 2020: A descriptive analysis

Epidemiological characteristics of occupational chemical poisonings in Zhejiang, China from 2006 to 2020: A descriptive analysis

Influence ofVDRandHFEpolymorphisms on blood lead levels of occupationally exposed workers

Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation

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