Evaluation of possible mechanisms of Cordia dichotoma fruits for hyperlipidemia controlling in Wistar albino rats

El-Newary, Samah A.; Ibrahim, Abeer Y.

doi:10.4103/2221-1691.235325

Cited by 7 publications

(12 citation statements)

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“…These findings agreed with El-Fattah et al ( 61 ), who reported that camel milk’s DPPH% inhibition was 18.57%, whereas CMP’s TPC and DPPH% were 682.70 mg/100 g and 80.70%, respectively. Several previous reports ( 25 , 59 , 62 ) explained that fruit from Cordia myxa is rich in bioactive compounds such as flavonoids and phenolics.…”

Section: Resultsmentioning

confidence: 92%

“…Another study ( 65 ) revealed that camel milk yogurt’s pH and TA values increased when it was fortified with monk fruit sweetener. The pulp-induced high-viscosity conditions greatly raised ( p ≤ 0.05) the viscosity values of the treatments enhanced with CMP, and this rise was proportionate to the fortification ratios ( 25 ). Similarly, earlier investigations ( 30 , 65 ) found that the viscosity of camel milk yoghurt increased when sidr fruit pulp or monk fruit sweetness was added.…”

Section: Resultsmentioning

confidence: 99%

“…Fruits have hepatoprotective, wound-healing, anti-ulcer, and anthelmintic properties, as well as hypolipidemic and anti-diabetic properties ( 22–24 ). Polyphenols, flavonoids, alkaloids, and mucilage are just a few of the essential substances found in Cordia myxa fruit ( 25 ). The viscid layer aqueous extract contains the major polyphenols quercetin, rosmarinic acid, caffeic acid, kaempferol, chlorogenic acid, and rutin ( 26–28 ).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the physicochemical and sensory characteristics of fermented camel milk fortified with Cordia myxa and its biological effects against oxidative stress and hyperlipidemia in rats

et al. 2023

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Natural feed additives and their potential benefits in production of safe and highly nutritious food have gained the attention of many researchers the last decades. Cordia myxa is a nutrient-dense food with various health benefits. Despite this fact, very limited studied investigated the physicochemical and sensory impacts of incorporation of fermented camel milk with Cordia myxa and its biological effects. The current study aimed to assess the physical, chemical, and sensory characteristics of fermented camel milk (FCM) fortified with 5, 10, and 15% Cordia myxa pulp. The study demonstrated that fortification of camel milk efficiently enhanced protein, total solids, ash, fiber, phenolic substance, and antioxidant activity. When compared to other treatments, FCM supplemented with 10% Cordia myxa pulp had the best sensory features. In addition, FCM fortified with 10% Cordia myxa pulp was investigated as a potential inhibitor of hypercholesterolemia agents in obese rats. Thirty-two male Wistar rats were split into two main groups including normal pellet group (n = 8) served as negative control group (G1) and a group of hyperlipidemic animals (n = 24) were feed on a high-fat diet (HFD). Hyperlipidemic rats group (n = 24) were then divided into three subgroups (8 per each); second group or positive control (G2) which include hyperlipidemic rats received distilled water (1 mL/day), the third group (G3) involved hyperlipidemic rats feed on FCM (10 g/day) and the fourth group (G4) included hyperlipidemic animals feed on 10 g/day FCM fortified with 10% of Cordia myxa pulp by oral treatment via an intestinal tube for another 4 weeks. In contrast to the positive control group, G4 treated with Cordia myxa showed a substantial decrease in malondialdehyde, LDL, cholesterol, triglycerides, AST, ALT, creatinine, and urea levels, while a significant increase in HDL, albumin, and total protein concentrations. The number of large adipocytes decreased while the number of small adipocytes increased after consumption of fortified FCM. The results indicated that fermented milk fortified with Cordia myxa pulp improved the functions of the liver and kidney in hyperlipidemic rats. These results demonstrated the protective effects of camel milk and Cordia myxa pulp against hyperlipidemia in rats.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of the physicochemical and sensory characteristics of fermented camel milk fortified with Cordia myxa and its biological effects against oxidative stress and hyperlipidemia in rats

et al. 2023

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“…The effect of selected defatted flaxseed extract on the serum total cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL) and triglycerides levels of rats were determined by using method as described by (El-Newary et al,2018).…”

Section: Serum Lipid Profilementioning

confidence: 99%

Hypocholesterolemic Effect of Microwave Assisted Defatted Flaxseed Extract in Experimental Rats

Khalil¹

2020

J microb biotech food sci

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The research was aimed to determine the hypocholesterolemic property of microwave assisted defatted flaxseed extract (MADFEs) on rat model under study. The study trial included 25 male rats which were separated into 5 groups having 5 rats in each group. Twenty rats out of 25 were hypercholesterolemic and remaining 5 were normal rats. High cholesterol diet was administered for 15 days in order to induce hypercholesterolemia, and after the induction these rats were administered different concentrations of MADFEs (150, 300 & 450mg/kg B.W.) for a time interval of 28 days. A significant reduction was observed in the levels of lipid profile parameters by the administration of extracts. The extract at a dose of 300mg/kg B.W. was shown to have provided optimal results displaying lowered cholesterol content, triglyceride and LDL-c by 16.79%, 15.41% and 12.68%, while the level of HDL elevated by 14.71% in comparison to the control Fo group. Likewise, the percent increase in the concentrations of catalase and SOD by 10.89% and 29.38%. The study determined that MADFEs displayed hypocholesterolemic effect and can be utilized for its therapeutic benefits. The lignin present in defatted flaxseed provide with the potential against diseases.

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“… 2007 ), antioxidant (El-Newary et al. 2018 ), anti-inflammatory (Sharma et al. 2014 ), hypolipidemic (Sulieman and El-Newary 2014 ), and anticancer and antitumor (Ibrahim et al.…”

Section: Introductionmentioning

confidence: 99%

Sperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of Cordia dichotoma fruits

El-Newary

Aly

Hameed

et al. 2022

Pharmaceutical Biology

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Context Cordia dichotoma Forst. (Boraginaceae) has potent pharmacological impact. Meanwhile, its effect on fertility is unclear. Objective This study investigates the effect of Cordia fresh fruits hydroethanolic extract on fertility. Materials and methods 120 Wistar albino male rats were divided into four groups ( n = 30). The first group was negative control, and the second, third, and fourth groups received 125, 250, and 500 mg extract/kg bodyweight for 56 days. After 56 days, Cordia force-feeding stopped, and all groups were kept under laboratory conditions for another month to study the recovering effect. Results After day 56, extract at 500 mg/kg significantly reduced sperm total count, motility%, and alive%, to 47.60 ± 2.27 × 10 6 sperm/mL, 43.33% ± 1.49, and 63.67% ± 1.19, respectively, abnormalities% increased considerably (26.67% ± 0.54), compared to the negative control. Also, significant depletion on follicle-stimulating hormone (2.66 ± 0.21 mIU/L), luteinizing hormone (1.07 ± 0.06 mIU/L), and testosterone (2.69 ± 0.13 nmol/L) level was recorded, compared to the negative control. Cordia negative effect showed on histopathological studies of testes, prostate, and seminal vesicles. Fortunately, these adverse effects of Cordia recovered remarkably after stopping administration for one month. Conclusions Cordia antifertility effect may be due to its hypocholesterolemic effect, where cholesterol, the steroid cycle precursor, was significantly reduced. This study can be incorporated in clinical research after being repeated on another small experimental animal, their offspring, and one large experimental animal, then going to a clinical study that we plan to do in the future.

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Evaluation of possible mechanisms of Cordia dichotoma fruits for hyperlipidemia controlling in Wistar albino rats

Cited by 7 publications

References 0 publications

Assessment of the physicochemical and sensory characteristics of fermented camel milk fortified with Cordia myxa and its biological effects against oxidative stress and hyperlipidemia in rats

Assessment of the physicochemical and sensory characteristics of fermented camel milk fortified with Cordia myxa and its biological effects against oxidative stress and hyperlipidemia in rats

Hypocholesterolemic Effect of Microwave Assisted Defatted Flaxseed Extract in Experimental Rats

Sperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of Cordia dichotoma fruits

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