Evaluation of pomegranate (Punica granatum) pericarp aqueous extract on Eimeria spp. from Japanese quails (Coturnix japonica)

Berto, Bruno Pereira; Borba, HH; Santos, Hataânderson Luíz Cabral dos; Lima, Viviane Moreira de; Flausino, Walter; Teixeira-Filho, Walter L.; Lopes, Carlos Wilson Gomes

doi:10.1016/j.ijvsm.2014.02.002

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…Our research showed that P. granatum has dose-dependent in vitro anticoccidial effect on oocyst sporulation, which is due to a variety of bioactive phytochemical constituents. According to the most recent research, PGY has 100% sporulation inhibition as well as 48.60% for PGE at 72 and 96 h. These results are consistent with earlier studies that found punicalagin to be an effective anticoccidial monomer in P. granatum (Al-Shaibani et al, 2020;Amer et al, 2015;Berto et al, 2014;Dkhil, 2013;Khorrami et al, 2022;Yang et al, 2022) and may be attributable to the fruit harvested in Yemen having higher quantities of polyphenolic compounds.…”

Section: Discussionsupporting

confidence: 85%

In vitro studies for antiparasitic activities of Punica granatum extract

Al‐Shaebi,

Al‐Quraishy,

Maodaa

et al. 2023

Microscopy Res & Technique

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Because of the drug resistance, medicinal plants are used more frequently than coccidiostats to treat and control coccidiosis. Punica granatum is a powerful antioxidant with a variety of medicinal uses. This study used an in vitro experiment to investigate how different P. granatum from Yemen (Y) and Egypt (E) sources affected oocyst sporulation and served as an anthelminthic effector. In contrast to PGE and mebendazole, PGY (200 mg/mL) has the shortest time to paralyze and death the earthworm Eisenia fetida in this investigation. In addition, the treated worm groups' cuticle thickness and shrinkage in comparison to the control group were assessed and contrasted. Eimeria papillata is used as a model protozoan parasite in anticoccidial assays. This study shows that P. granatum affects oocysts sporulation in a dose‐dependent manner, with maximal percentages of 100% (PGY) and 48.60% (PGE) at 96 h for P. granatum concentrations of 200 mg/mL. Inhibition (%) was compared to various detergents, as well as positive and negative controls. According to our research, the P. granatum extract had powerful anthelmintic and anticoccidial properties, with the potency changing according to the environmental conditions of each fruit source.Research Highlights Habitat of the plant is useful for production and accumulation of some secondary metabolites in plants which be effective for the therapeutic uses. Different parameters in the environmental ecosystem affecting variation in chemical compositions and biological activity of P. granatum.

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Section: Discussionsupporting

confidence: 85%

In vitro studies for antiparasitic activities of Punica granatum extract

Al‐Shaebi,

Al‐Quraishy,

Maodaa

et al. 2023

Microscopy Res & Technique

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“…Over time, chickens ( Gallus gallus domesticus ) were object of an intensive genetic selection to respond to market demands, becoming an animal model in biomedical and biomolecular investigations through increasing the scientific knowledge ( Khajali, 2022 ). Japanese quails ( Coturnix japonica ) represent one of the valid alternatives to chickens due to their easy adaptation, low capital investments, and rapid turnover ( Berto et al . , 2014a ).…”

Section: Introductionmentioning

confidence: 99%

Differential diagnosis of Eimeria species in farmed Japanese quails (Coturnix japonica)

Zoroaster,

Singh,

Marchiori

et al. 2024

Poultry Science

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“…17 Extracts of the peel of P. granatum were reported to have anti-coccidial properties in both mice and Japanese quail. 18,19 In vitro and in vivo anthelmintic effect of pomegranate leaves and stem bark extracts were lethal to S. mansoni adult worms. 19 The P. granatumextracts was significantly found to reduced the number and diameter of hepatic granulomas, decrease the number of schistosomal eggs in liver tissues, lowerthe liver inflammatory infiltration, and decrease the hepatic fibrosis in mice.…”

Section: Introductionmentioning

confidence: 99%

“…18,19 In vitro and in vivo anthelmintic effect of pomegranate leaves and stem bark extracts were lethal to S. mansoni adult worms. 19 The P. granatumextracts was significantly found to reduced the number and diameter of hepatic granulomas, decrease the number of schistosomal eggs in liver tissues, lowerthe liver inflammatory infiltration, and decrease the hepatic fibrosis in mice. 20 In previous studies, we demonstrated the lethal effect of P. granatum ellagitannins against both miracidia and cercariae of S. mansoni.…”

Section: Introductionmentioning

confidence: 99%

In vitro Effects of Punica granatum Ellagitannins on Adult Worms of Schistosoma mansoni

Abozeid

El-Badawy

Mahmoud

et al. 2020

RRTM

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Schistosomiasis ranks second behind malaria in terms of overall morbidity and mortality. We evaluated the lethal effect of Punica granatum ellagitannins, extracted from the fruit rind, placenta and barks of the root and stem, on adult worms of Schistosoma mansoni (S. mansoni) . All four ellagitannins were lethal to S. mansoni adult worms. However, while the rind ellagitannins were the most potent, placental ellagitannins were the least. Rind ellagitannins were capable of killing 40% of adult worms at a concentration of 25µg/mL after 5 days. The killing of 100% of the worms was achievable by rind ellagitannins at a concentration of 50µg/mL after 5 days. The LD 50S of the rind ellagitannins after 96h and 120h were 41.25 µg/mL and 28.73 respectively. Ellagitannins-treated worms suffered from erosions, wrinkles, swellings and losses, degenerations of the surface tubercles and tegument. In addition, ellagitannins induced deformation and degradation of oral and ventral suckers and degenerations in the muscles of worms. Ellagitannins also caused a separation of coupled worms and reduction of their motility. Data obtained suggest that ellagitannins of pomegranate could be considered as a cheap candidate for the treatment of schistosomiasis.

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Evaluation of pomegranate (Punica granatum) pericarp aqueous extract on Eimeria spp. from Japanese quails (Coturnix japonica)

Cited by 5 publications

References 16 publications

In vitro studies for antiparasitic activities of Punica granatum extract

In vitro studies for antiparasitic activities of Punica granatum extract

Differential diagnosis of Eimeria species in farmed Japanese quails (Coturnix japonica)

<p>In vitro Effects of <em>Punica granatum</em> Ellagitannins on Adult Worms of <em>Schistosoma mansoni</em></p>

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