Evaluation of polymeric PLGA nanoparticles conjugated to curcumin for use in aPDT

Pietra, Renata Celi Carvalho de Souza; Cruz, Rosana C.; Melo, Carla Nunes de; Rodrigues, Lívia Bomfim; Santos, Patrícia Campi; Bretz, Gabriel Pissolati Matos; Soares, Betânia Maria; Sousa, Gerdal Roberto de; Ferreira, Marta Araújo Tavares; Cisalpino, Patrícia Silva; Magalhães, Paula Prazeres; Farias, Luiz de Mácêdo; Pinotti, Marcos

doi:10.1590/s2175-97902017000216043

Cited by 14 publications

(6 citation statements)

References 35 publications

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“…A possible explanation is that curcumin and the PLGA molecules around it help to create hydrogen connections between their C=O atoms. Other PLGA nanoparticles showed similar effects [ 42 , 50 , 51 ]; absorption curcumin bands were covered partially or totally by the PLGA nanoparticles complex.…”

Section: Resultsmentioning

confidence: 87%

PEG 400:Trehalose Coating Enhances Curcumin-Loaded PLGA Nanoparticle Internalization in Neuronal Cells

et al. 2023

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This work proposes a combination of polyethylene glycol 400 (PEG) and trehalose as a surface modification approach to enhance PLGA-based nanoparticles as a drug carrier for neurons. PEG improves nanoparticles’ hydrophilicity, and trehalose enhances the nanoparticle’s cellular internalization by inducing a more auspicious microenvironment based on inhibiting cell surface receptor denaturation. To optimize the nanoprecipitation process, a central composite design was performed; nanoparticles were adsorbed with PEG and trehalose. PLGA nanoparticles with diameters smaller than 200 nm were produced, and the coating process did not considerably increase their size. Nanoparticles entrapped curcumin, and their release profile was determined. The nanoparticles presented a curcumin entrapment efficiency of over 40%, and coated nanoparticles reached 60% of curcumin release in two weeks. MTT tests and curcumin fluorescence, with confocal imaging, were used to assess nanoparticle cytotoxicity and cell internalization in SH-SY5Y cells. Free curcumin 80 µM depleted the cell survival to 13% at 72 h. Contrariwise, PEG:Trehalose-coated curcumin-loaded and non-loaded nanoparticles preserved cell survival at 76% and 79% under the same conditions, respectively. Cells incubated with 100 µM curcumin or curcumin nanoparticles for 1 h exhibited 13.4% and 14.84% of curcumin’s fluorescence, respectively. Moreover, cells exposed to 100 µM curcumin in PEG:Trehalose-coated nanoparticles for 1 h presented 28% fluorescence. In conclusion, PEG:Trehalose-adsorbed nanoparticles smaller than 200 nm exhibited suitable neural cytotoxicity and increased cell internalization proficiency.

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Section: Resultsmentioning

confidence: 87%

PEG 400:Trehalose Coating Enhances Curcumin-Loaded PLGA Nanoparticle Internalization in Neuronal Cells

et al. 2023

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“…This clearly indicates the importance of stirring speed of the system in gaining the smaller PDI. that preparation of Curcumin-PLGA nano-particles in presence of Sodium docecyl sulfate (SDS) causes similar effect on this peak (Pietra et al, 2017). The intensity of IR peaks is proportional to the changes in dipole moment that a bond undergoes during a vibration (Arrondo et al, 1993).…”

Section: Discussionmentioning

confidence: 93%

Development and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach

Bahadorı

Eskandari

Ebrahimi

et al. 2019

European Journal of Pharmaceutical Sciences

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“…During the past years, numerous researchers have incorporated CUR into different pharmaceutical formulations (chitosan-alginate sponges, polymeric bandages, etc. ), though none of the processes increased the potential of CUR in the wound healing process (Pietra et al, 2017;Akbik et al, 2014). The suggestion, based on some other studies evaluating the activity of CUR as an anti-cancer agent, is that its healing potential might be increased by incorporating this curcuminoid into nano-vesicles (Akbik et al, 2014).…”

Section: Curcumin Nanoliposomes Mitigate Wound Tissue Inflammatory Re...mentioning

confidence: 99%

Curcumin nanoliposomes mitigate wound tissue inflammatory response caused by tooth extraction

Todorovic

Stojiljković

Ilić

et al. 2022

Braz. J. Pharm. Sci.

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Curcumin is a plant-derived compound with polypharmacological properties that are hampered by its poor solubility, fast degradation, etc. Wound closure complications that follow tooth extraction are numerous, and relatively frequently additional treatment is needed to prevent unwanted process chronification. The present study aims to compare the effects of free and the nanoliposome-encapsulated curcumin on tooth extraction wound closure. The experiments were performed on Wistar rats where both forms of curcumin were applied topically on a tooth extraction wound for seven days. Changes in tissue oxidative stress (malondialdehyde and oxidized proteins concentrations, and catalase activity) and inflammation (nitric oxide levels and myeloperoxidase activity) related parameters were studied three and seven days following the tooth extraction. Also, the extent of pathohistological changes and osteopontin immunohistochemical expression were studied. The obtained results indicate that both forms of curcumin prevent an increase in oxidative stress and inflammation-related parameters in the studied samples at 3-and 7-day time points. Additionally, we found that curcumin diminished tissue inflammatory response and osteopontin expression, while at the same time it caused faster granulation tissue maturation. The encapsulation of curcumin in nanoliposomes proved to be better in improving the extraction wound healing process than the free curcumin, giving this formulation a potential in the pharmaceutical industry.

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Evaluation of polymeric PLGA nanoparticles conjugated to curcumin for use in aPDT

Cited by 14 publications

References 35 publications

PEG 400:Trehalose Coating Enhances Curcumin-Loaded PLGA Nanoparticle Internalization in Neuronal Cells

PEG 400:Trehalose Coating Enhances Curcumin-Loaded PLGA Nanoparticle Internalization in Neuronal Cells

Development and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach

Curcumin nanoliposomes mitigate wound tissue inflammatory response caused by tooth extraction

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