Evaluation of Polyethylene Glycol Based Hydrogel for Tissue Sealing After Laparoscopic Partial Nephrectomy in a Porcine Model

Park, Eugene L.; Ulreich, Judith B.; Scott, Katherine; Ullrich, Nathan P.F.; Linehan, Jennifer; French, Michael H.; Ho, W. Y.; White, Melanie J.N.; Talley, John R.; Fellah, Abdul M.; Ramakumar, Sanjay

doi:10.1097/01.ju.0000138159.69642.d9

Cited by 25 publications

(11 citation statements)

References 18 publications

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“…Delayed and recurrent chronic inflammatory and granulomatous reactions could be seen in response to some synthetic gels [42]. However, polyethylene glycol based biodegradable hydrogels used as tissue sealants do not appear to induce immediate humoral or cellular immune reactions [43, 44]. …”

Section: Issues Of Immune Response To Foreign Proteins and Biomateriamentioning

confidence: 99%

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Uibo

Laidmäe

Sawyer

et al. 2009

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Polymeric scaffolds formed from synthetic or natural materials have many applications in tissue engineering and medicine, and multiple material properties need to be optimized for specific applications. Recent studies have emphasized the importance of the scaffolds’ mechanical properties to support specific cellular responses in addition to considerations of biochemical interactions, material transport, immunogenicity, and other factors that determine biocompatibility. Fibrin gels formed from purified fibrinogen and thrombin, the final two reactants in the blood coagulation cascade, have long been shown to be effective in wound healing and supporting the growth of cells in vitro and in vivo. Fibrin, even without additional growth factors or other components has potential for use in neuronal wound healing in part because of its mechanical compliance that supports the growth of neurons without activation of glial proliferation. This review summarizes issues related to the use of fibrin gels in neuronal cell contexts, with an emphasis on issues of immunogenicity, and considers the potential advantages and disadvantages of fibrin prepared from non-mammalian sources.

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Section: Issues Of Immune Response To Foreign Proteins and Biomateriamentioning

confidence: 99%

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Uibo

Laidmäe

Sawyer

et al. 2009

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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“…[10–12] PEO-based hydrogels, such as FocalSeal ® , CoSeal ® , and DuraSeal ® , have satisfactory mechanical performance, are non-immunogenic, and have been used in cardiovascular, [13,14] pulmonary, [15,16] and dural [17,18] surgical procedures, among others. [19,20] …”

Section: Introductionmentioning

confidence: 99%

Mechanically Robust, Negative‐Swelling, Mussel‐Inspired Tissue Adhesives

Barrett

Bushnell

Messersmith

2012

Adv Healthcare Materials

198

171

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Most synthetic polymer hydrogel tissue adhesives and sealants swell considerably in physiologic conditions, which can result in mechanical weakening and adverse medical complications. Herein, we describe the synthesis and characterization of mechanically tough zero- or negative-swelling mussel-inspired surgical adhesives based on catechol-modified amphiphilic poly(propylene oxide)-poly(ethylene oxide) block copolymers. The formation, swelling, bulk mechanical, and tissue adhesive properties of the resulting thermosensitive gels were characterized. Catechol oxidation at or below room temperature rapidly resulted in a chemically cross-linked network, with subsequent warming to physiological temperature inducing a thermal hydrophobic transition in the PPO domains and providing a mechanism for volumetric reduction and mechanical toughening. The described approach can be easily adapted for other thermally sensitive block copolymers and cross-linking strategies, representing a general approach that can be employed to control swelling and enhance mechanical properties of polymer hydrogels used in a medical context.

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“…At 30 and 60 days, no CoSeal was visible grossly or histologically [64]. The hydrogel provided satisfactory hemostasis in a porcine model, and the authors detected no humoral or cell-mediated immune response to the sealant 2 weeks after surgery [65]. The acute inflammation and foreign-body reaction were found to subside by 6-12 weeks [65].…”

Section: Hydrogel-based Sealantsmentioning

confidence: 92%

“…The hydrogel provided satisfactory hemostasis in a porcine model, and the authors detected no humoral or cell-mediated immune response to the sealant 2 weeks after surgery [65]. The acute inflammation and foreign-body reaction were found to subside by 6-12 weeks [65]. However, when compared with intracorporeal suturing and a fibrin sealant in a porcine model, CoSeal was inferior and was found to not adhere as well to the nephrectomy bed, and one animal experienced significant bleeding [66].…”

Section: Hydrogel-based Sealantsmentioning

confidence: 95%

A Review of Methods for Hemostasis and Renorrhaphy After Laparoscopic and Robot-assisted Laparoscopic Partial Nephrectomy

Rajan

Leveillee

2010

Curr Urol Rep

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The techniques for management of small renal masses (SRMs) have evolved over the past several years. Radical nephrectomy can lead to an increased risk of chronic kidney disease, and the emphasis is now shifting to nephron-conserving techniques. Partial nephrectomy is now considered a standard of care for the management of SRMs, and laparoscopic techniques are becoming popular because they are minimally invasive. The kidneys are extremely vascular organs, and renal hemorrhage is a major cause of morbidity after laparoscopic partial nephrectomies. Control of bleeding and management of calyceal injuries can be difficult and make the procedure technically challenging. This review looks at the various modalities that are available to reduce bleeding and reviews some advances in the area of hemostatic maneuvers during laparoscopic partial nephrectomies.

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Evaluation of Polyethylene Glycol Based Hydrogel for Tissue Sealing After Laparoscopic Partial Nephrectomy in a Porcine Model

Cited by 25 publications

References 18 publications

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Soft materials to treat central nervous system injuries: Evaluation of the suitability of non-mammalian fibrin gels

Mechanically Robust, Negative‐Swelling, Mussel‐Inspired Tissue Adhesives

A Review of Methods for Hemostasis and Renorrhaphy After Laparoscopic and Robot-assisted Laparoscopic Partial Nephrectomy

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