Evaluation of Poly(lactic-co-glycolic Acid) Plate and Screw System for Bone Fixation

Park, Subin; Kim, Jin Hee; Kim, Il Hwan; Lee, Minsu; Heo, Su‐Hak; Hong, Kim Jae; Kim, Eun Hee; Choy, Young Bin; Heo, Chan Yeong

doi:10.1097/scs.0b013e31827fee09

Cited by 27 publications

(12 citation statements)

References 12 publications

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“…Future work should investigate dynamic testing of motion segments and their biomechanics in the full six degrees of freedom characteristic of the spine. Second, while favorable outcomes in terms of durability and minimal negative inflammatory responses have been shown in cranio‐maxillo‐facial approaches with several animal models using PLGA plates and screws, their load‐bearing capacity remains limited . Recent work by Maenz et al with PLGA‐reinforced calcium phosphate cement in ovine VBs suggests a potential use in load‐bearing structures given the versatility and manufacturability of PLGA.…”

Section: Discussionmentioning

confidence: 99%

Resorbable plating system stabilizes tissue‐engineered intervertebral discs implanted ex vivo in canine cervical spines

et al. 2018

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Total disc replacement using tissue‐engineered intervertebral discs (TE‐IVDs) may offer a biological alternative to treat radiculopathy caused by disc degeneration. A composite TE‐IVD was previously developed and evaluated in rat tail and beagle cervical spine models in vivo. Although cell viability and tissue integration into host tissue were promising, significant implant displacement occurred at multiple spinal levels. The goal of the present study was to assess the effects of a resorbable plating system on the stiffness of motion segments and stability of tissue‐engineered implants subjected to axial compression. Canine motion segments from levels C2/C3 to C5/C6 were assessed as intact (CTRL), after discectomy (Dx), with an implanted TE‐IVD only (PLATE−), and with a TE‐IVD combined with an attached resorbable plate (PLATE+). Segments under PLATE+ conditions fully restored separation between endplates and showed significantly higher compressive stiffness than segments under PLATE− conditions. Plated segments partially restored more than 25% of the CTRL motion segment stiffness. Plate attachment also prevented implant extrusion from the disc space at 50% compressive strain, and this effect was more significant in segments from levels C3/C4 when compared to segments from level C5/C6. These results suggest that stabilization of motion segments via resorbable plating assists TE‐IVD retention in the disc space while allowing the opportunity for implants to fully integrate into the host tissue and achieve optimal restoration of spine biomechanics.

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Section: Discussionmentioning

confidence: 99%

Resorbable plating system stabilizes tissue‐engineered intervertebral discs implanted ex vivo in canine cervical spines

et al. 2018

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“…For this property, PLLA has been used as a source reagent of bioresorbable osteosynthetic materials since the 1990s [5,6]. In 2006, new biomaterial for osteosynthesis was developed, which was composed of incalescent/unsintered hydroxyapatite (u-HA) particles and PLLA, and has been commonly used due to (1) its better osteoconductivity [7][8][9][10], (2) no need for secondary surgery to remove the materials [11,12], (3) no restriction to bone growth in young patients [13][14][15], and (4) no elution of metal ions that could act as allergens [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Irradiation with a 405 nm Blue-Violet Laser on the Bacterial Adhesion on the Osteosynthetic Biomaterials

Terada

Imamura

Ohshima

et al. 2018

International Journal of Photoenergy

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Delayed postoperative infection is known as a major complication after bone surgeries using osteosynthetic biomaterial such as titanium (Ti) and bioresorbable organic materials. However, the precise cause of this type of infection is still unclear and no effective prevention has been established. The purpose of this study is to investigate the effect of irradiation with a 405 nm blue-violet laser on the bacteria adhered on the Ti and hydroxyapatite-poly-L-lactic acid- (HA-PLLA) based material surfaces and to verify the possibility of its clinical application to prevent the delayed postoperative infection after bone surgeries using osteosynthetic biomaterial. The suspension of Staphylococcus aureus FDA 209P was delivered onto the surface of disks composed of Ti or HA-PLLA. Bacterial adhesion on each disk was observed using a scanning electron microscope (SEM). After thorough washing with distilled water, the growth of bacteria attached to the material surfaces was examined with an alamar blue-based redox indicator. Moreover, a bactericidal effect of 405 nm blue-violet laser irradiation on residual bacteria on both materials was investigated using colony-forming assay. As a result, there was no significant difference in the bacterial adhesion between Ti and HA-PLLA materials. In contrast, 45 J/cm2 of irradiation with 405 nm blue-violet laser inhibited the bacterial growth at approximately 93% on Ti disks and at approximately 99% on HA-PLLA disks. This study clearly demonstrated the possibility that the irradiation with a 405 nm blue-violet laser is useful as an alternative management strategy for the prevention of delayed postoperative infection after bone surgeries using osteosynthetic biomaterials.

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“…[12][13][14] The screws maintained adequate strength for across the recovery period (ie, bone healing), which is typically known to require as long as 8 to 12 weeks. 9,[15][16][17][18][19][20] In general, although biodegradables themselves may not be as strong as metal, we suggest that they can still provide adequate fixation for complete bone healing (Fig. 5).…”

Section: Discussionmentioning

confidence: 92%

A Simple and Reliable Method of Narrowing Genioplasty Using Biodegradable Screws

Lee¹

2016

Journal of Craniofacial Surgery

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The T-osteotomy technique is widely performed to improve lower face aesthetics. During this narrowing genioplasty procedure, metal fixtures are required to rigidly fix the bone segments. Specifically, the use of biodegradable osteofixations has become a viable surgical option as more patients now have the desire to surreptitiously undergo aesthetic surgery. The present report describes a narrowing genioplasty procedure with the use of biodegradable screws only. When the T-osteotomy technique was performed to narrow the chin, the bone segments were first temporarily fixed with a 4-hole titanium plate and screws. Later during the operation, the plate and screws were replaced with 4 biodegradable screws with bicortical fixation. Completion of bone healing can be confirmed by follow-up radiographs taken 6 months after the surgery. Despite increasing demand for the use of absorbable materials in aesthetic surgeries, biodegradable fixation systems have not been widely used for aesthetic surgeries due to a perception of high cost, inconvenient manipulation, prolonged operative time, and suspicions on long-term stability. Our novel method of using only biodegradable screws allows such limitations to be easily overcome by surgeons.

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Evaluation of Poly(lactic-co-glycolic Acid) Plate and Screw System for Bone Fixation

Cited by 27 publications

References 12 publications

Resorbable plating system stabilizes tissue‐engineered intervertebral discs implanted ex vivo in canine cervical spines

Resorbable plating system stabilizes tissue‐engineered intervertebral discs implanted ex vivo in canine cervical spines

The Effect of Irradiation with a 405 nm Blue-Violet Laser on the Bacterial Adhesion on the Osteosynthetic Biomaterials

A Simple and Reliable Method of Narrowing Genioplasty Using Biodegradable Screws

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