Evaluation of poly(L-lactic acid) as a material for intravascular polymeric stents

Agrawal, C. Mauli; Haas, K. F.; Leopold, David A.; Clark, Haydn

doi:10.1016/0142-9612(92)90068-y

Cited by 149 publications

(108 citation statements)

References 20 publications

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“…[ 23] , who tested in vitro the pressure-diameter behaviour of the Duke biodegradable stents made of PLLA fibres. They reported that with a careful balance between fibre mechanical properties (varied with draw ratio and thermal treatments) and stent designs, it was possible to achieve a successful biodegradable stent.…”

Section: Degradation Behaviourmentioning

confidence: 99%

Research into biodegradable polymeric stents: a review of experimental and modelling work

Qiu¹,

Zhao²

2018

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Bioresorbable stents (BRSs) are regarded as the next-generation medical devices to treat blocked or diseased arteries.The use of BRSs aims to reduce the risk of late stent thrombosis and long-term tissue inflammation associated with permanent metallic stents. BRSs are designed to relieve symptoms immediately and also provide mechanical support for an appropriate time period before they are fully absorbed by human body. To promote clinical adoption of BRSs or even to substitute metallic stents, the mechanical performance of BRSs needs to be thoroughly investigated and quantitatively characterised, especially over the full period of degradation. This paper offers a review of current research status of polymeric BRSs, covering both experimental and modelling work. Review of experimental studies highlighted the effects of stent designs and materials on the behaviour of polymeric BRSs. Computational work was able to simulate crimping, expansion and degradation of polymeric BRSs and the results were useful for performance assessment. In summary, the development of polymeric BRSs is still at an early stage, and further research is urgently required for a better understanding and control of their mechanical performance.

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Section: Degradation Behaviourmentioning

confidence: 99%

Research into biodegradable polymeric stents: a review of experimental and modelling work

Qiu¹,

Zhao²

2018

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“…[9] One of the major concerns for polymeric BRSs is their mechanical performance, especially their interaction with blood vessels during and after deployment. Agrawal et al [10] carried out the earliest work in assessing the in vitro performance of the Duke biodegradable stents made of Poly-L lactide (PLLA) fibres. Results showed that a successful biodegradable stent could be achieved by carefully balancing the mechanical properties of PLLA fibres and geometrical design of stents.…”

Section: Introductionmentioning

confidence: 99%

Crimping and deployment of metallic and polymeric stents -- finite element modelling

Schiavone¹,

Qiu²,

Zhao³

2017

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How to cite this article: Schiavone A, Qiu TY, Zhao LG. Crimping and deployment of metallic and polymeric stents --finite element modelling. Vessel Plus 2017;1:12-21.Aim: This paper aims to compare the mechanical performance of metallic (Xience) and bioresorbable polymeric (Elixir) stents during the process of crimping and deployment. Methods: Finite element software ABAQUS was used to create the geometrical models and meshes for the balloon, stent and diseased artery. To simulate the crimping of stents, 12 rigid plates were generated around the stent and subjected to radially enforced displacement. The deployment of both stents was simulated by applying internal pressure to the balloon, where hard contacts were defined between balloon, stent and diseased artery. Results: Elixir stent exhibited a lower expansion rate than Xience stent during deployment. The stent diameter achieved after balloon deflation was found smaller for Elixir stent due to higher recoiling. Lower level of stresses was found in the plaque and artery when expanded by Elixir stent. Reduced expansion, increased dogboning and decreased vessel stresses were obtained when considering the crimping-generated residual stresses in the simulations. Conclusion: There is a challenge for polymeric stents to match the mechanical performance of metallic stents. However, polymeric stents impose lower stresses to the artery system due to less property mismatch between polymers and arterial tissues, which could be clinically beneficial. Key words:Polymeric stents, metallic stents, finite element, crimping, deployment ABSTRACTArticle history:

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“…Biopolymers are desired for blood-contact applications such as tissue-engineered blood vessels and polymer stents. [1][2][3][4] Unfortunately, these polymers have been found to give rise to adverse effects such as blood clots and tissue capsulation by interface reaction between artificial surface and biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Medical Applications of Lotus-leaf-like Structured Superhydrophobic Surfaces

임진익¹,

김승일²,

정영미³

et al. 2013

Polymer Korea

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Various biomaterials have been widely used for biomedical applications, including bio-organs, medical devices, and clinical devices like vessel, blood pumps, artificial kidneys and hearts, even in contact with blood. The issue of blood compatibility has been studied intensively to prevent negative effects such as thrombosis due to the implanted devices. The use of lotus-leaf-like structured surfaces has been extended to an increasing number of applications such as contamination prevention and anticorrosion applications. Various methods such as template, sol-gel transition, layer-bylayer, and other methods, developed for the fabrication of lotus-leaf-like surfaces have been reported for major industrial applications. Recently, the non-wettable character of these surfaces has been shown to be useful for biomedical applications ranging from blood-vessel replacement to antibacterial surface treatment. In this review, we provide a summary of current and future research efforts and opportunities in the development and medical applications of lotus-leaf-like structure surfaces.

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Evaluation of poly(L-lactic acid) as a material for intravascular polymeric stents

Cited by 149 publications

References 20 publications

Research into biodegradable polymeric stents: a review of experimental and modelling work

Research into biodegradable polymeric stents: a review of experimental and modelling work

Crimping and deployment of metallic and polymeric stents -- finite element modelling

Fabrication and Medical Applications of Lotus-leaf-like Structured Superhydrophobic Surfaces

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