Evaluation of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO) gels as a release vehicle for percutaneous fentanyl

In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles

“…11 By measuring the intensity ratios of the first to the third vibrational bands of pyrene, it was found that the I 1 /I 3 peak height ratio decreased above 0.1% w/w of only block copolymers (Figure 1, triangles). The magnitude of I 1 /I 3 in the high concentration range (here 1.55) is somewhat higher than that for pyrene in a toluene solution (1.04) but significantly lower than that in water (1.75).…”

“…10 This PEO-type carrier of block copolymer not only leads to enhanced passive transport but also avoids liver degradation. In our previous study, 11 we found through pharmacokinetic data, that using a PEO-PPO-PEO copolymer micelle-fentanyl patch in vivo prolonged the half-life (t 1/2 ) of fentanyl in the blood stream up to five times. Thus, this type of copolymer micelle carrier appears to have the potential to act as a topical drug delivery carrier since it prevents serum/protein interaction and the micelle carrier has good stability characteristics.…”

“…11 The different weighed amounts of copolymer were added to water with gentle mixing. Different concentrations of plasmid were gently mixed with PEO-PPO-PEO polymeric micelles in a vial for 2 h.…”

“…11 The fluorescence emission spectrum of pyrene in the PEO-PPO-PEO copolymer micelle solutions was measured from 350 to 500 nm using a fixed excitation wavelength of 339 nm with a constant pyrene concentration of 6 × 10 −7 m. The PEO-PPO-PEO block copolymer varied from 0.001% to 20% (w/w) with or without 0.08 g/ l of plasmid. The spectral data were acquired using a Hitachi F-4500 fluorescence spectrophotometer (Hitachi, Tokyo, Japan).…”

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

“…Studies on PEO-PPO-based polymeric micelles for transdermal drug delivery have been widely carried out with Poloxamer 407 (Pluronic F127) and these studies mostly focused on small drug molecules in order of anti-inflammatory [8][9][10][11][12][13][14][15][16][17][18][19], analgesic [20], local anesthetic [21] and cardiac effectiveness [19,[22][23][24] and rarely focused on big molecules such as arginine vasopressin (AVP) and insulin [25,26].…”