Evaluation of platelet-rich plasma gel potential in acceleration of wound healing duration in patients underwent pilonidal sinus surgery: A randomized controlled parallel clinical trial

Effectiveness of platelet‐rich plasma therapy in wound healing of pilonidal sinus surgery: A comprehensive systematic review and meta‐analysis

“…Among 11 eligible articles found, four were selected according to the criteria already mentioned in method section. Among these four articles, three were in English and one was in Russian which was translated by a bilingual medical doctor. Only one trial had been published before 2013.…”

“…Thus, they suggested angiogenesis as a possible pathway in PRP‐induced accelerated wound healing; since the angiogenic inducers such as VEGF, PDGF, and PDAF are concentrated in PRP . Mohammadi et al hypothesized that the reason underlying both less pain and less antibiotic consumption in patients treated with PRP is the higher angiogenesis rate …”

Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation

“…All patients were cancer-free according to according to their clinical and para-clinical evaluation. An exclusion criteria were defined as follows: lower platelet count of <10 3 µL, hemoglobin <10g/dL, anti-proliferative therapies such as chemotherapy in the past 3 months, anti-inflammation medications in the past 2 weeks, radiation in the past 3 months, growth factor therapies in the last 2 weeks, history of diabetes, history of mal-absorption (celiac disease) and any contra-indication in peripheral venues access (Mohammadi et al, 2017b). All the patients were asked to sign a written consent form freely after explanation of all the aspects of study according to their level of knowledge.…”

“…Over the last decades, the role of platelet-derived growth factors has been highlighted in regenerative medicine (Mostafaei et al). Plateletderived growth factors are biologic active compounds and also acting in different mechanisms and pathways including activation or induction of chemotaxis, cellular proliferation and angiogenesis (Mohammadi et al, 2016;Mohammadi et al, 2017b). Platelet related products have been a satisfactory outcome in the treatment of chronic skin and soft tissue lesions and plastic surgeries (Serra-Mestre et al, 2014;Mohammadi et al, 2017a).…”

Celecoxib, Angiogenesis, and Wound Healing

“…In other words, only a few physi-W ological processes like wound healing and the female reproductive cycle are dependent on angiogenesis [7,8]. In wound healing, angiogenesis is very important due to its role in supplying nutrition and oxygenation for proliferating cells and also removing waste materials from both necrotic and proliferating tissues [9,10]. Angiogenesis is induced by different cytokines such as Hypoxia-Inducible Factor α (HIF-α), Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF), Matrix MetalloProteinases (MMPs), Platelet-Derived Growth Factor (PDGF), Angiopoietin 1 (Ang-1) and Tumor Necrosis Factor α (TNF-α).…”