Evaluation of platelet-rich plasma efficacy in melasma

Acar, Ayda; Ozturk, Ayris; Sokmen, Nur; Ünal, İdil; Ertam, İlgen

doi:10.1080/14764172.2022.2099898

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Therefore, novel therapeutic approaches are urgently needed. PRP, a recent approach for treating melasma, has provided significant therapeutic benefits in recent years [13,14], which produces large quantities of growth factors when activated, which can improve pigmentation [15][16][17]. However, several problems are associated with the use of PRP for the treatment of melasma, including the use of anticoagulants, cumbersome preparation steps that may increase the risk of bacterial contamination, and a shorter maintenance period when growth factors are present at higher concentrations due to the fast rate of protein coagulation [18].…”

Section: Discussionmentioning

confidence: 99%

Treatment with injectable platelet-rich fibrin in a rat model of melasma

Liang,

Wang,

Xiang

et al. 2023

European Journal of Dermatology

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Background: The management of melasma is challenging. Plateletrich plasma (PRP) therapy has been shown to be beneficial, however, the use of anticoagulants for PRP is dangerous. Objectives: To evaluate the efficacy of recently developed blood-derived biomaterials (injectable platelet-rich fibrin [I-PRF]) in a rat model of melasma. Materials & Methods: Sprague Dawley (SD) rats were used to replicate an experimental animal model of melasma. SD rats exhibiting melasma were randomly divided into experimental and control groups. The experimental group was administered weekly intradermal injections of I-PRF, whereas the control group received an equivalent amount of saline. After four weeks, back skin was removed and evaluated based on (1) gross observation, (2) pathological examination and imaging analysis, and (3) biochemical detection. Data were analysed using SAS9.4 software. Results: I-PRF, a safe blood product without anticoagulants, inhibited melanin production in the epidermis and reduced oxidative stress damage in the cortex, improving melasma. Conclusion: I-PRF is a safe and cost-effective blood-derived biomaterial which is useful for the treatment of melasma.

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Section: Discussionmentioning

confidence: 99%

Treatment with injectable platelet-rich fibrin in a rat model of melasma

Liang,

Wang,

Xiang

et al. 2023

European Journal of Dermatology

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“…Platelet-rich plasma (PRP), a commonly utilized treatment in various dermatologic conditions, has emerged as a viable option for addressing melasma in recent years [ 53 ]. Its effectiveness in melasma treatment lies in its ability to inhibit melanin synthesis through delayed extracellular signal-regulated kinase activation.…”

Section: Managementmentioning

confidence: 99%

Management of Melasma: Laser and Other Therapies—Review Study

Jiryis,

Toledano,

Avitan-Hersh

et al. 2024

JCM

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Melasma is a commonly occurring pigmented skin condition that can significantly affect one’s appearance, described as symmetric hyperpigmentation that presents as irregular brown to gray-brown macules on various facial areas, such as the cheeks, forehead, nasal bridge, and upper lip, along with the mandible and upper arms. Due to its complex pathogenesis and recurrent nature, melasma management is challenging and the outcomes following treatment are not always deemed satisfactory. Solely treating hyperpigmentation may prove ineffective unless paired with regenerative techniques and photoprotection, since one of the main reasons for recurrence is sun exposure. Hence, the treatment protocol starts with addressing risk factors, implementing stringent UV protection, and then treatment using different strategies, like applying topical treatments, employing chemical peels, laser and light therapies, microneedling, and systemic therapy. This review aims to provide a summary of the effectiveness and safety of the frequently employed laser and light therapies for treating melasma, focusing on laser therapy as a treatment for melasma.

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Autolougous platelet concentrates in esthetic medicine

Davies,

Miron

2024

Periodontology 2000

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This narrative review summarizes current knowledge on the use of autologous platelet concentrates (APCs) in esthetic medicine, with the goal of providing clinicians with reliable information for clinical practice. APCs contain platelets that release various growth factors with potential applications in facial and dermatologic treatments. This review examines several facial esthetic applications of APCs, including acne scarring, skin rejuvenation, melasma, vitiligo, stretchmarks, peri‐orbital rejuvenation, peri‐oral rejuvenation, hair regeneration and the volumizing effects of APC gels. A systematic review of literature databases (PubMed/MEDLINE) was conducted up to October 2023 to identify randomized controlled trials (RCTs) in the English language on APCs for facial rejuvenation and dermatology. A total of 96 articles were selected including those on platelet rich plasma (PRP), plasma‐rich in growth factors (PRGF), and platelet‐rich fibrin (PRF). Clinical recommendations gained from the reviews are provided. In summary, the use of APCs in facial esthetics is a promising yet relatively recent treatment approach. Overall, the majority of studies have focused on the use of PRP with positive outcomes. Only few studies have compared PRP versus PRF with all demonstrating superior outcomes using PRF. The existing studies have limitations including small sample sizes and lack of standardized assessment criteria. Future research should utilize well‐designed RCTs, incorporating appropriate controls, such as split‐face comparisons, and standardized protocols for APC usage, including optimal number of sessions, interval between sessions, and objective improvement scores. Nevertheless, the most recent formulations of platelet concentrates offer clinicians an ability to improve various clinical parameters and esthetic concerns.

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Evaluation of platelet-rich plasma efficacy in melasma

Cited by 4 publications

References 10 publications

Treatment with injectable platelet-rich fibrin in a rat model of melasma

Treatment with injectable platelet-rich fibrin in a rat model of melasma

Management of Melasma: Laser and Other Therapies—Review Study

Autolougous platelet concentrates in esthetic medicine

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