Evaluation of Platelet Indices and Red Cell Distribution Width as New Biomarkers for the Diagnosis of Acute Appendicitis

Boshnak, Noha H; Boshnaq, Mohamed; Elgohary, Hatem

doi:10.1080/08941939.2017.1284964

Cited by 64 publications

(87 citation statements)

References 49 publications

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“…Recently, Plt counts and Plt-related parameters (such as PBW, MPW) have become the focus of interest for various diseases. Some studies have shown that Plt counts decrease in AA (36). In our study, Plt counts were significantly lower in the AG than in the CG (p<0.03).…”

Section: The Demographic Results Of Groupssupporting

confidence: 45%

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

Demir¹,

Günal²,

Özmen³

et al. 2020

Turkish Journal of Pediatric Disease

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Objective: We aimed to investigate the potential of assessing thiol/disulfide homeostasis as novel oxidative stress markers to improve the challenging diagnosis of acute appendicitis in children. Material and Methods: A total of 60 pediatric patients (0-18 years) were enrolled in the study, 30 of which were in the control group and 30 in the acute appendicitis group. Native thiol, total thiol, dynamic disulfide, dynamic thiol, ischemia modified albümin, albumin, White blood cell, hemoglobin, hematocrit, and platelet counts of both groups were measured. The results of both groups were compared using the SPSS (Statistical Package for Social Sciences) version 17 (Chicago, USA) program. For all variables, p <0.05 was considered significant. Results: Total thiol (p<0.001), native thiol (p<0.001), and albümin (p<0.001) levels were significantly decreased while dynamic disulfide, dynamic thiol (p=0.003), and ischemia modified albümin (p<0.001) levels those indicating oxidant side were increased in acute appendicitis group compared to control. White blood cell counts in acute appendicitis group were higher (p<0.001), and platelet counts were lower (p=0.03) than the control group. Conclusion: In the differential diagnosis of acute appendicitis, especially in case that are difficult to diagnose, besides a physical examination, imaging, and current laboratory tests, quantification of thiol/disulfide homeostasis may be helpful in diagnosing. In addition, evaluating albumin and IMA levels may increase the specificity of the test. This test can be more helpful in cases diagnosis is difficult such as children small in their ages and mental retardation.

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Section: The Demographic Results Of Groupssupporting

confidence: 45%

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

Demir¹,

Günal²,

Özmen³

et al. 2020

Turkish Journal of Pediatric Disease

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“…PDW values were significantly higher in the patient group than in the control group. 23,24 There are studies which found similar results and opposite results with our study. [23][24][25] It is known that WBC values are frequently elevated in patients with acute appendicitis.…”

Section: Discussioncontrasting

confidence: 36%

“…23,24 There are studies which found similar results and opposite results with our study. [23][24][25] It is known that WBC values are frequently elevated in patients with acute appendicitis. 23,26 In our study, WBC count was significantly higher in the acute appendicitis group.…”

Section: Discussioncontrasting

confidence: 36%

“…The platelet counts were also within the normal range in a similar study. 23 Thus, we think that platelet count is insufficient for a clinical decision of acute appendicitis. PDW values were significantly higher in the patient group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25] It is known that WBC values are frequently elevated in patients with acute appendicitis. 23,26 In our study, WBC count was significantly higher in the acute appendicitis group. Nevertheless, high WBC values alone are insufficient as a diagnostic tool in patients with appendicitis.…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Acute Appendicitis and Platelet Indices in Childhood

Sucu¹,

Tolunay²,

Cesur³

et al. 2018

cayd

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Introduction:Appendicitis is the inflammation of the appendix vermiformis. Clinical diagnosis of acute appendicitis in children is still a problem. Platelet indices, platelet distribution width and mean platelet volume have been evaluated for some infectious and inflammatory diseases. In this study, we aimed to investigate whether platelet distribution width values and mean platelet volume were decisive for the diagnosis of appendicitis in children. Methods: In our hospital, 504 pediatric patients who presented with acute abdomen and received the diagnosis of acute appendicitis between 2011 and 2016, and 106 children living in the same region, who attended the pediatric outpatient clinics for general followup, were included in the study. The patient and control groups were analyzed for gender, age, platelet count, platelet distribution width and mean platelet volume. A receiver operating characteristic (ROC) curve was drawn to describe the parameters that may be statistically significant. Results: There was a significant difference in platelet distribution width and mean platelet volume values between the two groups (p<0.001). The platelet distribution width values were higher and the mean platelet volume values were lower in appendicitis patients than in healthy children. The ROC curve analysis suggested a cut-off value of >14.3 fL for platelet distribution width for the diagnosis of appendicitis with a sensitivity, specificity, positive predictive value, and negative predictive value of 77.6%, 85.8%, 96.3%, and 44.6%, respectively. A cut-off value of <9.35 fL for mean platelet volume was used for the diagnosis of appendicitis with a sensitivity, specificity, positive predictive value, and negative predictive value of 78.1%, 81.1%, 95.2%, and 43.9%, respectively. Conclusion: Our results suggest that platelet distribution width and mean platelet volume may be used for the diagnosis of appendicitis in children with the sensitivity of at least 77.6% and 78.1%, respectively. Mean platelet volume and platelet distribution width, which can easily be investigated in complete blood count, may serve as markers for the diagnosis of appendicitis in children, however, further large-scale studies are needed. Keywords: Appendicitis, mean platelet volume, platelet indices, platelet distribution width Giriş: Apandisit appendiks vermiformisin iltihaplanmasıdır. Akut apandisitin klinik tanısı çocuklarda hala bir problemdir. Trombosit indeksleri, ortalama trombosit dağılım genişliği ve trombosit hacmi, bazı enfeksiyöz ve enflamatuvar hastalıklar için değerlendirilmiştir. Bu çalışmada, çocuklarda apandisit tanısı için ortalama trombosit dağılım genişliği ve trombosit hacmi değerlerinin belirleyici olup olmadığını araştırmayı amaçladık. Yöntemler: Hastanemizde, 2011-2016 yılları arasında akut karın nedeniyle akut apandisit tanısı alan 504 çocuk ve aynı bölgede yaşayan sağlam çocuk polikliniğine genel takip için başvuran 106 çocuk çalışmaya alındı. Hasta ve kontrol grupları cinsiyet, yaş, trombosit sayısı, ortalama trombosit dağılım...

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Clinical-pathological features and treatment of acute appendicitis in the very elderly: an interim analysis of the FRAILESEL Italian multicentre prospective study

Fransvea

Fico

Cozza

et al. 2021

Eur J Trauma Emerg Surg

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Background emergency abdominal surgery in the elderly represents a global issue. Diagnosis of AA in old patients is often more di cult. Appendectomy remains the gold standard of treatment and, even though it is performed almost exclusively with a minimally invasive technique, it can still represent a great risk for the elderly patient, especially above 80 years of age. A careful selection of elderly patients to be directed to surgery is therefore fundamental. The primary aim was to critically appraise and compare the clinical-pathological characteristics and the outcomes between oldest old (≥ 80 years) and elderly (65-79 years) patients with Acute Appendicitis (AA). MethodsThe FRAILESEL is a large, nationwide, multicenter, prospective study investigating the perioperative outcomes of patients aged ≥ 65 years who underwent emergency abdominal surgery. Particular focus has been directed to the clinical and biochemical presentation as well as to the need for operative procedures, type of surgical approach, morbidity and mortality, and in-hospital length of stay. Two multivariate logistic regression analyses were performed to assess perioperative risk factors for morbidity and mortality. Results182 patients ful lled the inclusions criteria. Mean age, ileocecal resection, OAD and ASA score ≥ 3 were related with both overall and major complication. The multivariate analysis showed that MPI and complicated appendicitis were independently factors associated with overall complications. OAD and ASA score ≥ 3 were independently factors for both overall and major complications. Conclusionsage ≥ 80 years is not an independent risk factor for morbidities. POCUS is safe and effective for the diagnosis; however, a CECT is often needed Having the oldest old a smaller functional organ reserve, an earlier intervention is needed, especially because they required greater rate of major resection.

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Evaluation of Platelet Indices and Red Cell Distribution Width as New Biomarkers for the Diagnosis of Acute Appendicitis

Abstract: Increased PDW combined with elevated WBC and neutrophil counts maybe used as diagnostic tests in the cases of acute appendicitis, while MPV and RDW levels were not useful diagnostic markers.

Cited by 64 publications

References 49 publications

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

Tiyol / Disülfit dengesinin değerlendirilmesi çocuklarda apandisitin ayırıcı tanısında yardımcı olabilir mi?

Relationship Between Acute Appendicitis and Platelet Indices in Childhood

Clinical-pathological features and treatment of acute appendicitis in the very elderly: an interim analysis of the FRAILESEL Italian multicentre prospective study

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