Evaluation of placental oxygenation in fetal growth restriction using blood oxygen level-dependent magnetic resonance imaging

Magawa, Shoichi; Nii, Masafumi; Enomoto, Naosuke; Takakura, Satoshi; Maki, Seijiro; Tanaka, Hiroaki; Ishida, Masaki; Kondo, Eiji; Sakuma, Hajime; Ikeda, Tomoaki

doi:10.1016/j.placenta.2022.06.005

Cited by 8 publications

(5 citation statements)

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“…These findings underscore the potential value of these biomarkers in improving our understanding and detection of placental hypoxia in pregnancy complications (Figure 2). 25,28,30,38], CAIX [13,42,43], miR-210 [14,[46][47][48][49][50], T2* MRI [16,55,56,59,[62][63][64], PAI [35,37,67] Studying molecular or imaging biomarkers solely has established consistent findings in associating placental hypoxia with an increase in molecular biomarkers such as HIFa, CAIX, and miR-210 levels or a decrease in imaging biomarker values obtained by T2* MRI and PAI. On the other hand, few preclinical studies using PAI have explored the integration of molecular and imaging biomarkers to validate their findings.…”

Section: Discussion: the Integration Of Molecular And Imaging Biomark...mentioning

confidence: 85%

“…This suggests that the levels of oxygen Overview of the molecular and imaging biomarkers of placental hypoxia. HIF-α [16][17][18][19][20][21][22][23][24][25]28,30,38], CAIX [13,42,43], miR-210 [14,[46][47][48][49][50], T2* MRI [16,55,56,59,[62][63][64], PAI [35,37,67].…”

Section: Discussion: the Integration Of Molecular And Imaging Biomark...mentioning

confidence: 99%

“…Limited studies used oxygenation challenge with MRI to assess the placental condition in abnormal pregnancies. In cases diagnosed with FGR, the peak delta R2* (1/T2*) value, representing a change in oxygen saturation levels, during hyperoxia was lower in FGR cases compared to healthy controls [ 59 ]. However, another study found no difference in delta T2* values in the placenta [ 60 ].…”

Section: Imaging Biomarkers Of Hypoxiamentioning

confidence: 99%

“… Overview of the molecular and imaging biomarkers of placental hypoxia. HIF-α [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 28 , 30 , 38 ], CAIX [ 13 , 42 , 43 ], miR-210 [ 14 , 46 , 47 , 48 , 49 , 50 ], T2* MRI [ 16 , 55 , 56 , 59 , 62 , 63 , 64 ], PAI [ 35 , 37 , 67 ]. …”

Section: Figurementioning

confidence: 99%

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From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes

Al Darwish,

Meijerink,

Coolen

et al. 2023

Cells

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Placental hypoxia poses significant risks to both the developing fetus and the mother during pregnancy, underscoring the importance of early detection and monitoring. Effectively identifying placental hypoxia and evaluating the deterioration in placental function requires reliable biomarkers. Molecular biomarkers in placental tissue can only be determined post-delivery and while maternal blood biomarkers can be measured over time, they can merely serve as proxies for placental function. Therefore, there is an increasing demand for non-invasive imaging techniques capable of directly assessing the placental condition over time. Recent advancements in imaging technologies, including photoacoustic and magnetic resonance imaging, offer promising tools for detecting and monitoring placental hypoxia. Integrating molecular and imaging biomarkers may revolutionize the detection and monitoring of placental hypoxia, improving pregnancy outcomes and reducing long-term health complications. This review describes current research on molecular and imaging biomarkers of placental hypoxia both in human and animal studies and aims to explore the benefits of an integrated approach throughout gestation.

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Section: Discussion: the Integration Of Molecular And Imaging Biomark...mentioning

confidence: 85%

Section: Discussion: the Integration Of Molecular And Imaging Biomark...mentioning

confidence: 99%

Section: Imaging Biomarkers Of Hypoxiamentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes

Al Darwish,

Meijerink,

Coolen

et al. 2023

Cells

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show abstract

“…We previously demonstrated that placental oxygenation was significantly reduced in the FGR group than in controls. 25,26 As efficient oxygen extraction requires sufficient fetal blood flow in the intervillus and chorionic villi, it is likely that fetal blood flow and chorionic villus changes in FGR reduce oxygen extraction efficiency. 27 Additionally, the days to delivery were significantly shorter in the FGR group than in the controls in the present study; this might be due to insufficient blood flow between the uterus and placenta owing to placental abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Two-dimensional phase-contrast magnetic resonance imaging reveals changes in uterine arterial blood flow in pregnant women treated with tadalafil for fetal growth restriction: A prospective study.

Nii

Enomoto

Ishida

et al. 2023

Preprint

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Objective: To examine the effect of uterine arterial (UtA) blood flow changes after tadalafil treatment for fetal growth restriction (FGR) using two-dimensional (2D) phase-contrast magnetic resonance imaging (PC-MRI). Design: Prospective, controlled study. Setting: Single tertiary center. Population or Sample: Fourteen pregnant women with FGR aged 20–44 years and at ≥20 weeks’ gestation were recruited between May 2019 and July 2020. Methods: They underwent 2D PC-MRI for UtA blood flow measurement 3 days after diagnosis. They were compared with 14 gestational age (GA)-matched healthy pregnant women (control group). Six patients in the FGR group received tadalafil at 20 mg twice daily after the first MRI until delivery. They underwent a second MRI 1 week later and were compared with 6 of the 14 GA-matched healthy pregnant women. Main Outcome Measures: Total UtA blood/body surface area Results: The median total UtA blood/body surface area was 420 mL/min/m (290–494) in the FGR group and 547 mL/min/m (433–681) in the control group (p=0.01). Percent increases of blood flow in the FGR and control groups were significantly different at 68.8% (51–75) and 18.8% (16–57), respectively (p<0.01). Both intraobserver reproducibility (r=0.997, p<0.01; intraclass correlation coefficients (ICC), 0.997) and interobserver reproducibility (r=0.997, p<0.01; ICC, 0.998) were high. Conclusions: UtA blood flow in pregnant women with FGR was significantly lower than that in healthy pregnant women. Tadalafil may improve UtA blood flow, thereby improving placental function in pregnant patients with FGR.

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Two-dimensional phase-contrast MRI reveals changes in uterine arterial blood flow in pregnant women administered tadalafil for fetal growth restriction

Nii,

Enomoto,

Ishida

et al. 2024

Placenta

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Evaluation of placental oxygenation in fetal growth restriction using blood oxygen level-dependent magnetic resonance imaging

Cited by 8 publications

References 44 publications

From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes

From Molecules to Imaging: Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes

Two-dimensional phase-contrast magnetic resonance imaging reveals changes in uterine arterial blood flow in pregnant women treated with tadalafil for fetal growth restriction: A prospective study.

Two-dimensional phase-contrast MRI reveals changes in uterine arterial blood flow in pregnant women administered tadalafil for fetal growth restriction

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