Evaluation of pirenzepine on gastric acidity in healthy volunteers using ambulatory 24 hour intragastric pH-monitoring.

Etienne, Andre; Fimmel, Claus J.; Bron, B; Loizeau, E; Blum, A. L.

doi:10.1136/gut.26.3.241

Cited by 35 publications

(9 citation statements)

References 7 publications

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“…Intragastric pH monitoring has been used in the past years mainly for controlling Hr blocker and antacid therapy [8][9][10], For this latter purpose Walt [11] and Merki et al [ 12] have given directions of evaluation and Merki et al have shown its reproducibility.…”

Section: Discussionmentioning

confidence: 99%

Intragastric pH Pattern Analysis in Patients with Duodenogastric Reflux

Fuchs

DeMeester²

1990

Dig Dis

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The intention of the present study was to apply 24-hour intragastric pH monitoring as a diagnostic tool for the detection of pathologic duodenogastric reflux. Therefore, an evaluation system was developed which is able to recognize and quantify specific intraluminal gastric pH patterns regarding their specificity for the disease. pH parameters, stored during 24 h and processed, according to the evaluation system, were obtained for a healthy control population (n = 30) and for patients with pathologic duodenogastric reflux (n = 11). These data were subjected to computerized discriminant analysis to identify pH changes with a high probability of resulting from pathologic duodenogastric reflux. The computer analysis identified 16 discriminating pH parameters to separate a physiologic pH pattern from a 24-hour intragastric pH pattern with a high probability of being associated with pathologic duodenogastric reflux.

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Section: Discussionmentioning

confidence: 99%

Intragastric pH Pattern Analysis in Patients with Duodenogastric Reflux

Fuchs

DeMeester²

1990

Dig Dis

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“…The ability of the electrodes to detect small changes of acidity and the reproducibility of the procedure are now well established [2,3]. Measurements have generally been used to assess the effects of new antisecretory drugs and therefore analytical methods are re quired to enable one to distinguish true dif ferences between drugs or different doses.…”

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confidence: 99%

“…The vol ume of data collected enables us to review critically the distributions and patterns of acidity that were less clear when few mea surements were usual. This paper presents, in two parts, the arguments relating to the handling of individual pH recordings and the problems associated with group analy ses.The technique of continuous gastric pH recording has previously been described [1][2][3], Regular pH measurements from intra gastric electrodes are transferred via solid state recording devices to computer discs. The ability of the electrodes to detect small changes of acidity and the reproducibility of the procedure are now well established [2,3].…”

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confidence: 99%

Analysis and Statistical Evaluation of Continuous pH Recordings

Röhmel¹,

Merki

Wilder‐Smith

et al. 1990

Dig Dis

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“…Continuous 24-hour pH measurement by means of intraluminal glass or antimony electrodes [1][2][3][4][5][6] is coming of age and is replacing the standard hourly aspiration method [7][8][9][10] in the assessment of intra gastric acidity, especially in pharmacological studies. In a recent investigation [11] we showed that good correlation exists between hourly pH values measured simultaneously in the stomach with an antimony minielec trode and in gastric aspirates.…”

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confidence: 99%

Comparison of Gastric Aspiration and Continuous pH Monitoring with Antimony Electrode: Methodological Remarks

Savarino¹,

1990

Dig Dis

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In an attempt to eliminate the noise affecting continuous 24-hour intragastric pH metry curves in order to obtain a more appropriate identification of hourly intraluminal pH values to which the corresponding aspirate ones were compared, the raw data of one of our previous experiments were treated using a smoothing technique (removal of noise peaks was followed by moving averages on three adjacent points, 1 min apart, which were applied both singly and combined with Fourier’s filtration employing the first 32 harmonics) A gradual improvement of all parameters of regression analysis from original data to those achieved with the two above-mentioned methods was found. In particular, the regression coefficient r increased from 0.83 to 0.88 with the singly moving averages technique and even to 0.95 when Fourier’s filtration was combined. Both techniques provided also similar improvement as far as slope and elevation values were concerned: the slope was almost equal to 1 and the elevation was very low, so that paired data might be assumed to be proportional. It can be concluded that hourly pH values of continuous intraluminal monitoring and those of simultaneous gastric aspiration appear better correlated if the elimination of noise disturbing the in vivo pH metry curves is obtained. With regard to this, the use of a combined smoothing-filtering technique, such as moving averages plus Fourier’s filtration after removal of the noise peaks, seems a very advantageous modality.

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Evaluation of pirenzepine on gastric acidity in healthy volunteers using ambulatory 24 hour intragastric pH-monitoring.

Abstract: SUMMARY The effect of pirenzepine on 24 hour intragastric acidity was studied in 10 healthy volunteers using ambulatory 24

Cited by 35 publications

References 7 publications

Intragastric pH Pattern Analysis in Patients with Duodenogastric Reflux

Intragastric pH Pattern Analysis in Patients with Duodenogastric Reflux

Analysis and Statistical Evaluation of Continuous pH Recordings

Comparison of Gastric Aspiration and Continuous pH Monitoring with Antimony Electrode: Methodological Remarks

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