“…Heat-separated epithelia were also included as one study reported the thickness of the heat-separated tissue to be 410 μ (43). The permeabilities for the following compounds were obtained from literature: sotalol, flecainide, morphine, zalcitabine, fentanyl, thiocolchicoside, nicotine, estradiol, triamcinololne acetonide, testosterone, labetalol, acebutolol, timolol, oxprenolol, alprenolol, and tertatolol (43)(44)(45)(46)(47)(48)(49)(50)(51). Sotalol was excluded as it has a logD 6.8 of −2.59, which is lower than that of atenolol, the most hydrophilic compound (logD 6.8 =−1.3) in the training group used in developing the model (16).…”