Evaluation of pig esophageal mucosa as a permeability barrier model for buccal tissue

In Silico Prediction of Drug Permeability Across Buccal Mucosa

“…Heat-separated epithelia were also included as one study reported the thickness of the heat-separated tissue to be 410 μ (43). The permeabilities for the following compounds were obtained from literature: sotalol, flecainide, morphine, zalcitabine, fentanyl, thiocolchicoside, nicotine, estradiol, triamcinololne acetonide, testosterone, labetalol, acebutolol, timolol, oxprenolol, alprenolol, and tertatolol (43)(44)(45)(46)(47)(48)(49)(50)(51). Sotalol was excluded as it has a logD 6.8 of −2.59, which is lower than that of atenolol, the most hydrophilic compound (logD 6.8 =−1.3) in the training group used in developing the model (16).…”

Transbuccal delivery of doxepin: Studies on permeation and histological investigation

“…These, are spherical or oval organelles which are 100-300 nm in diameter (Hayward, 1979). The arrangement of these lipids is quite amorphous, with only a minor component organized into lamellae, and it appears to be related to the permeability barrier (Diaz Del Consuelo et al, 2005b).…”

Transport of Fentanyl Through Pig Buccal and Esophageal Epithelia in Vitro. Influence of Concentration and Vehicle pH

“…Previously, we have shown that the in vitro permeability of fentanyl across buccal and esophageal mucosae is similar (4). Here, the influence of drug concentration and vehicle pH on the transport of fentanyl across buccal and esophageal epithelia in vitro was evaluated.…”