Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (Wall.): A comprehensive review

Sinha, Sunanda; Sharma, Aishwarye; Reddy, P. Madhusudhana; Rathi, Brijesh; Prasad, Neetu; Vashishtha, Amit

doi:10.1016/j.jopr.2013.04.004

Cited by 35 publications

(25 citation statements)

References 13 publications

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“…Holarrhena antidysenterica (L.) is a well-known plant in Asia that has been traditionally used to treat diarrhea, dysen-tery, inflammation, and hemorrhoids. Recently, some properties such as anti-oxidant, anti-malarial, anti-urolithic, and anti-diabetic have been revealed in HA extracts [9]. The bioactive compounds of HA may have the potential to act on pancreatic beta cells, inhibiting carbohydrate metabolizing enzymes and increasing blood glucose uptake by neighboring tissues (Indrayava).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes

Riaz

Ali

Qureshi

et al. 2020

Journal of Diabetes Research

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Background/Aim. Type 2 diabetes is the most common form of diabetes mellitus. The aim of this study was to develop and standardize the polyhedral formulation (granule) and check its efficacy with regard to type 2 diabetes. Methods. The alcoholic extract of each plant (H. antidysentrica, Prunus dulcis and Cicer arietinum) and oleic acid was mixed and then formulated by wet granulation method. FTIR was done to investigate the presence of active compounds. Physicochemical properties of granules were evaluated and antidiabetic potential was substantiated through inhibition of carbohydrate digestive enzyme (α-amylase and α-glucosidase), glucose uptake activity in yeast cells, and antioxidant activity. Results. IR spectra indicated the presence of active compounds by showing the characteristic peaks of phenols and amines. The FTIR results also showed no interaction between drug and excipients. The prepared granules exhibited excellent flow properties according to USP 30. The dissolution profile of active pharmaceutical ingredient (API) from granules showed 72–80% release in 2 hrs. Granules exhibited better inhibition of α-amylase and α-glucosidase as in comparison with the standard drug and found to be dose-dependent. The enhanced uptake of glucose was observed with a decrease in drug concentration. Moreover, the DPPH scavenging activity was high (98%) at 1 mg/ml. Conclusion. The stabilized formulation (granules) was formed and the presence of active compounds is responsible for better antidiabetic activity by inhibiting carbohydrate-digesting enzymes. Hence, it could lower the postprandial hyperglycemia and has the potential to be used for the treatment of type II diabetes after determining the dose regime.

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Section: Introductionmentioning

confidence: 99%

In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes

Riaz

Ali

Qureshi

et al. 2020

Journal of Diabetes Research

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“…H. antidysenterica (L.) Wall. ex A.DC., H. floribunda T.Durand & Schinz) are well studied, with steroidal alkaloids and glycosides of primary interest for their potential bioactivity (Kumar et al, 2007;Sinha et al, 2013). Three steroidal amino-glycosides previously reported from H. pubescens (holantosine B, D, and F, MW=475.3 Da) correspond in mass to one of the ions detected in PREC 120 (Afendi et al, 2011(Afendi et al, , queried 16.07.2020Janot et al, 1970).…”

Section: Malouetieaementioning

confidence: 99%

“…On the other hand, we assign low probability to presence of retronecine-type PAs in seeds of Holarrhena pubescens, separated from contaminating Wrightia tinctoria seeds. Because specialized metabolites of Holarrhena pubescens are so well studied (Sinha et al, 2013) and because neither of the candidate compounds fragmented in the PREC 138 and 156 scans (Table 2), we consider it more likely that the m/z 476 and 498 ions identified in PREC 120 correspond to other primary or secondary metabolites. We suggest that the Arseculeratne et al (1981) report of PAs in H. pubescens seeds derives from either non-specificity of their colorimetric assay or contamination by Wrightia spp.…”

Section: Implications For Human Healthmentioning

confidence: 99%

Chemotaxonomic Investigation of Apocynaceae for Retronecine-Type Pyrrolizidine Alkaloids Using HPLC-MS/MS

Barny

Tasca

Sánchez

et al. 2020

Preprint

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Apocynaceae are well-known for diverse specialized metabolites that are distributed in a phylogenetically informative manner. Pyrrolizidine alkaloids (PAs) have been reported sporadically in one lineage in the family, the APSA clade, but few species had been studied to date. We conduct the first systematic survey of Apocynaceae for retronecine-type PAs, sampling leaves from 231 species from 13 of 16 major lineages within the APSA clade using HPLC-MS/MS. We also follow up on preliminary evidence for infra-specific variation of PA detectability in Echites umbellatus Jacq. Four precursor ion scans (PREC) were developed for a high-throughput survey for chemicals containing a structural moiety common to many PAs, the retronecine core. We identified with high confidence PAs in 7 of 8 sampled genera of tribe Echiteae, but not in samples from the closely related Odontadenieae and Mesechiteae, confirming the utility of PAs as a taxonomic character in tribal delimitation. The presence of PAs in Malouetieae was confirmed, as we report with high confidence their presence in Galactophora schomburgkiana Woodson and Eucorymbia alba Stapf, but currently we have low confidence of their presence in Holarrena pubescens Wall. ex G. Don (the one Malouetieae species where they were previously reported), as well as in Kibatalia macrophylla (Pierre ex Hua) Woodson and in Holarrena curtisii King & Gamble. For the first time the presence of PAs in species of Wrightia R. Br. (Wrightieae) and Marsdenia R. Br. (Marsdenieae) was confirmed. Detectability of PAs was found to vary among samples of Echites umbellatus and intra-individual plasticity contributes to this variation. Of toxicological importance, novel potential sources of human exposure to pro-toxic PAs were identified in the medicinal plants, Wrightia tinctoria R.Br. and Marsdenia tinctoria R.Br., and the food plant, Echites panduratus A. DC., warranting immediate further research to elucidate the structures of the candidate PAs identified. Method development and limitations are discussed.

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“…Reported biological properties of H. antidysenterica include cytotoxic effects against human cell lines [170], antibacterial [171], anti-malarial [172], antioxidant, antihyperglycemic [173], and antidiarrheal activities [174]. In other studies, analgesic, anti-amoebic, anti-inflammatory, antihemorrhoidal, anti-diabetic, antiurolithic, anti-mutagenic properties, CNS-stimulating effects, angiotensin-converting-enzyme and acetylcholinesterase inhibitory activity have been proved [175]. The medicinal uses of H. antidysenterica are thus supported by sound scientific evidence.…”

Section: Desmodium Triquetum DCmentioning

confidence: 99%

A Review of Traditional Medicinal Plants from Kachin State, Northern Myanmar

Aung

Sein

Aye

et al. 2016

Natural Product Communications

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Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (Wall.): A comprehensive review

Cited by 35 publications

References 13 publications

In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes

In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes

Chemotaxonomic Investigation of Apocynaceae for Retronecine-Type Pyrrolizidine Alkaloids Using HPLC-MS/MS

A Review of Traditional Medicinal Plants from Kachin State, Northern Myanmar

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