Evaluation of phytochemical and antioxidant potential of various extracts from traditionally used medicinal plants of Pakistan

Jafri, Syed Anis Ali; Khalid, Zafar M.; Khan, Muhammad Zakryya; Jogezai, NaqeebUllah

doi:10.1515/chem-2022-0242

Cited by 14 publications

(8 citation statements)

References 47 publications

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“…The increase of reactive oxygen species in high-altitude areas can damage the cell membrane system, resulting in abnormal metabolism, and even cell death [36,54]. The antioxidant activity of medicinal plants is commonly evaluated by the scavenging rate of DPPH radicals and ABTS radicals [55]. In this study, a higher antioxidant capacity was observed in leaves at medium and high altitudes, corroborating the findings of Joshi et al [56].…”

Section: Discussionsupporting

confidence: 88%

Altitudinal Variation on Metabolites, Elements, and Antioxidant Activities of Medicinal Plant Asarum

Pan,

Yang,

Sui

et al. 2023

Metabolites

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Asarum (Asarum sieboldii Miq. f. seoulense (Nakai) C. Y. Cheng et C. S. Yang) is a medicinal plant that contains asarinin and sesamin, which possess extensive medicinal value. The adaptation and distribution of Asarum’s plant growth are significantly affected by altitude. Although most studies on Asarum have concentrated on its pharmacological activities, little is known about its growth and metabolites with respect to altitude. In this study, the physiology, ionomics, and metabolomics were investigated and conducted on the leaves and roots of Asarum along an altitude gradient, and the content of its medicinal components was determined. The results showed that soil pH and temperature both decreased along the altitude, which restricts the growth of Asarum. The accumulation of TOC, Cu, Mg, and other mineral elements enhanced the photosynthetic capacity and leaf plasticity of Asarum in high-altitude areas. A metabolomics analysis revealed that, at high altitude, nitrogen metabolism in leaves was enhanced, while carbon metabolism in roots was enhanced. Furthermore, the metabolic pathways of some phenolic substances, including syringic acid, vanillic acid, and ferulic acid, were altered to enhance the metabolism of organic acids. The study uncovered the growth and metabolic responses of Asarum to varying altitudes, providing a theoretical foundation for the utilization and cultivation of Asarum.

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Section: Discussionsupporting

confidence: 88%

Altitudinal Variation on Metabolites, Elements, and Antioxidant Activities of Medicinal Plant Asarum

Pan,

Yang,

Sui

et al. 2023

Metabolites

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“…These factors contribute to the fruits' overall nutritional and medicinal value. Phytochemical evaluation involves the analysis of bioactive compounds present in fruits, such as flavonoids, phenolic compounds, and other antioxidants, which contribute to their healthpromoting properties (Olaide et al, 2019, Jafri et al, 2022. The presence of phytochemicals in plants has been linked to their antioxidant and other healthpromoting properties (Akhtar et al, 2018, Jafri et al, 2022.…”

Section: Discussionmentioning

confidence: 99%

Phytochemicals, Mineral Elements and Antioxidants Evaluation of Some Commonly Consumed Desert Fruits

Danzomo,

Yunusa,

Adamu

et al. 2024

SAJOLS

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The medicinal properties of fruits are closely related to their available phytochemicals, as well as antioxidant capacity. Many of the indigenous fruits have been traditionally used as folk medicine. This study aims to evaluate the phytochemicals, mineral elements, and antioxidant properties of five (5) commonly consumed desert fruits such as Hyphaene thebaica, Detarium senegalensce, Ziziphus jujuba, Dialium guineense and Diospyros mespiliformis. The phytochemicals, mineral elements, and antioxidants were carried out using standard methods of analysis. The result revealed that phytochemicals such as alkaloids, flavonoids, phenols, tannins, saponins, steroids, terpenoids, and glycosides were present in all five fruits studied with varied compositions. While the mineral elements such as Potassium (K), Magnesium (Mg), Calcium (Ca), Sodium (Na), Iron (Fe), Manganese (Mn), Zinc (Zn), and Copper (Cu) were present indicated that the fruits have substantial mineral elements, however, varied according to the fruits species studied, Hyphaene thebaica exhibits the highest elemental content. The DPPH inhibition properties emphasize the diverse antioxidant capabilities of the studied fruits in which Diospyrosme spiliformis (DS) emerges as a standout in DPPH inhibition activity, exhibiting robust antioxidant activity, closely followed by Dialium guineense (DG). The nitric oxide radical scavenging reveals a concentration-dependent response in the NO radicals scavenging activity for all the fruits and ascorbic acid. The findings conclude that the five desert fruits species revealed different phyto-constituents, mineral elements, Nitric oxide radical scavenging effect, and DPPH inhibition properties suggesting potential medicinal and nutritional properties of the five desert fruits.

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“…Additionally, free radicals pose a constant threat to human health. These radicals are produced in our bodies during normal metabolic and physiological processes, leading to oxidative stress and the development of chronic diseases such as cancer, aging, diabetes, and inflammatory diseases [ 2 ]. As a result, one of the main objectives of global sustainable development is to support the search for affordable, safe, and effective critical medicines that promote good health [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Variation of antibacterial and antioxidant secondary metabolites and volatiles in leaf and callus extracts of Phulai (Acacia Modesta Wall.)

Hagaggi,

Abdul-Raouf,

Radwan

2024

BMC Plant Biol

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Background Acacia species are economically significant as medicinal plants that have been utilized since ancient times. Acacia modesta has been reported to possess potent antibacterial and antioxidant properties, but its growth rate is slow. In this study, we hypothesized that inducing callus in vitro from A. modesta could enhance the production of antibacterial and antioxidant secondary metabolites, thereby circumventing the issues of slow growth and excessive harvesting of the plant. Results The callus was induced from axillary buds on MS medium supplemented with 1 mg/L of 2,4-D and 1 mg/L of BAP. The secondary metabolites, volatile compounds, antibacterial activity, and antioxidant activity of the callus and parent plant leaf extracts were evaluated. The results revealed that the content of phenolics and flavonoids, the number of volatile compounds, and the antibacterial and antioxidant activities of the callus extract were significantly enhanced (P ≤ 0.05) compared to the leaf extract. The antibacterial and antioxidant effects were strongly correlated with the total phenolic and flavonoid content in the extracts. Conclusions Our findings suggest that in vitro callus culture increases the production of phenolics, flavonoids, and volatile compounds. This subsequently enhances the antibacterial and antioxidant properties of A. modesta.

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Evaluation of phytochemical and antioxidant potential of various extracts from traditionally used medicinal plants of Pakistan

Cited by 14 publications

References 47 publications

Altitudinal Variation on Metabolites, Elements, and Antioxidant Activities of Medicinal Plant Asarum

Altitudinal Variation on Metabolites, Elements, and Antioxidant Activities of Medicinal Plant Asarum

Phytochemicals, Mineral Elements and Antioxidants Evaluation of Some Commonly Consumed Desert Fruits

Variation of antibacterial and antioxidant secondary metabolites and volatiles in leaf and callus extracts of Phulai (Acacia Modesta Wall.)

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