Evaluation of physical, mechanical and biological properties of poly 3-hydroxybutyrate-chitosan-multiwalled carbon nanotube/silk nano-micro composite scaffold for cartilage tissue engineering applications

Mirmusavi, Mohammad Hossein; Zadehnajar, Parisa; Semnani, Dariush; Karbasi, Saeed; Fekrat, Farnoosh; Heidari, Fariba

doi:10.1016/j.ijbiomac.2019.03.227

Cited by 70 publications

(22 citation statements)

References 38 publications

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“…First, Ca 2+ ions in SFB are selectively adsorbed onto negatively charged surfaces (OH − groups of the CS). Second, PO 4 3− ions are attracted to the calcium-rich surfaces to form an amorphous calcium phosphate (ACP), and finally, the ACP is converted into apatite [ 9 , 13 , 17 , 35 ]. The presence of Ca and P ions in the first week of immersion of the cement specimens in SFB has been reported in the literature for cement formulations with CS loading > 20 wt.% [ 3 , 13 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Acrylic Bone Cement Incorporated with Low Chitosan Loadings

2020

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Despite the potential of acrylic bone cement (ABC) loaded with chitosan (CS) for orthopedic applications, there are only a few in vitro studies of this composite with CS loading ≤ 15 wt.% evaluated in bioactivity tests in simulated body fluid (SBF) for duration > 30 days. The purpose of the present work was to address this shortcoming of the literature. In addition to bioactivity, a wide range of cement properties were determined for composites with CS loading ranging from 0 to 20 wt.%. These properties included maximum exotherm temperature (Tmax), setting time (tset), water contact angle, residual monomer content, flexural strength, bending modulus, glass transition temperature, and water uptake. For cement with CS loading ≥ 15 wt.%, there was an increase in bioactivity, increase in biocompatibility, decrease in Tmax, increase in tset, all of which are desirable trends, but increase in residual monomer content and decrease in each of the mechanical properties, with each of these trends, were undesirable. Thus, a composite with CS loading of 15 wt.% should be further characterized to explore its suitability for use in low-weight-bearing applications, such as bone void filler and balloon kyphoplasty.

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Section: Discussionmentioning

confidence: 99%

Acrylic Bone Cement Incorporated with Low Chitosan Loadings

2020

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“…However, in contrast to these findings, other studies have reported no cytotoxicity effects when CNTs were incorporated into matrix-based materials for bone tissue-engineered scaffolds [162][163][164][165].…”

Section: Limitations and Toxicitymentioning

confidence: 65%

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

et al. 2020

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Bone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this context, porous biodegradable scaffolds have emerged as an interesting solution. They act as external support for cell growth and degrade when the defect is repaired. For an adequate performance, these scaffolds must meet specific requirements: biocompatibility, interconnected porosity, mechanical properties and biodegradability. To obtain the required porosity, many methods have conventionally been used (e.g., electrospinning, freeze-drying and salt-leaching). However, from the development of additive manufacturing methods a promising solution for this application has been proposed since such methods allow the complete customisation and control of scaffold geometry and porosity. Furthermore, carbon-based nanomaterials present the potential to impart osteoconductivity and antimicrobial properties and reinforce the matrix from a mechanical perspective. These properties make them ideal for use as nanomaterials to improve the properties and performance of scaffolds for bone tissue engineering. This work explores the potential research opportunities and challenges of 3D printed biodegradable composite-based scaffolds containing carbon-based nanomaterials for bone tissue engineering applications.

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“…Due to the low cost and versatility, chitosan is effective biomaterial as food packaging films [113,117], preservation of food [118] and drink [119], pharmaceutical science [120], cosmetics [121], or antibacterial agents [115]. In regenerative medicine, chitosan is often selected for blood vessels [42][43][44], cartilage [45][46][47][48][122][123][124], bone [49,50,125,126], the intervertebral disc [51][52][53]127,128], or skin [54,55,129] regeneration. For example, glycosaminoglycan (GAG) is essential to stimulate the formation of cartilage.…”

Section: Chitosanmentioning

confidence: 99%

Biomaterial-Assisted Regenerative Medicine

Nii

Katayama

2021

IJMS

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This review aims to show case recent regenerative medicine based on biomaterial technologies. Regenerative medicine has arousing substantial interest throughout the world, with “The enhancement of cell activity” one of the essential concepts for the development of regenerative medicine. For example, drug research on drug screening is an important field of regenerative medicine, with the purpose of efficient evaluation of drug effects. It is crucial to enhance cell activity in the body for drug research because the difference in cell condition between in vitro and in vivo leads to a gap in drug evaluation. Biomaterial technology is essential for the further development of regenerative medicine because biomaterials effectively support cell culture or cell transplantation with high cell viability or activity. For example, biomaterial-based cell culture and drug screening could obtain information similar to preclinical or clinical studies. In the case of in vivo studies, biomaterials can assist cell activity, such as natural healing potential, leading to efficient tissue repair of damaged tissue. Therefore, regenerative medicine combined with biomaterials has been noted. For the research of biomaterial-based regenerative medicine, the research objective of regenerative medicine should link to the properties of the biomaterial used in the study. This review introduces regenerative medicine with biomaterial.

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Evaluation of physical, mechanical and biological properties of poly 3-hydroxybutyrate-chitosan-multiwalled carbon nanotube/silk nano-micro composite scaffold for cartilage tissue engineering applications

Cited by 70 publications

References 38 publications

Acrylic Bone Cement Incorporated with Low Chitosan Loadings

Acrylic Bone Cement Incorporated with Low Chitosan Loadings

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

Biomaterial-Assisted Regenerative Medicine

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