Evaluation of physical and emotional responses to vibrotactile stimulation of the forearm in young adults, the elderly, and transradial amputees

Ko, Chang-Yong; Chang, Yun Hee; Kim, Solbi; Kim, Shin-Ki; Kim, Gyoosuk; Ryu, Jeicheong; Mun, Mu Seong

doi:10.1016/j.physbeh.2014.10.021

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…Yet, there is one major question that remains open: what is the mechanism that induces this improvement? We hypothesize that, like in the case of our previous results with the WANR, the concurrent occurrence of cortical plasticity, induced by BMI use 11,13,14 and spinal plasticity, promoted by sFES through ascending signals 59–61 was an essential agent for the observed neurological motor improvement in our study. Recent work with human subjects showed that the use of invasive epidural stimulation has the potential to induce partial neurological restoration in chronic complete SCI patients 9 .…”

Section: Discussionsupporting

confidence: 85%

Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia

Selfslagh

Shokur²,

Campos³

et al. 2019

Sci Rep

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Spinal cord injury (SCI) impairs the flow of sensory and motor signals between the brain and the areas of the body located below the lesion level. Here, we describe a neurorehabilitation setup combining several approaches that were shown to have a positive effect in patients with SCI: gait training by means of non-invasive, surface functional electrical stimulation (sFES) of the lower-limbs, proprioceptive and tactile feedback, balance control through overground walking and cue-based decoding of cortical motor commands using a brain-machine interface (BMI). The central component of this new approach was the development of a novel muscle stimulation paradigm for step generation using 16 sFES channels taking all sub-phases of physiological gait into account. We also developed a new BMI protocol to identify left and right leg motor imagery that was used to trigger an sFES-generated step movement. Our system was tested and validated with two patients with chronic paraplegia. These patients were able to walk safely with 65–70% body weight support, accumulating a total of 4,580 steps with this setup. We observed cardiovascular improvements and less dependency on walking assistance, but also partial neurological recovery in both patients, with substantial rates of motor improvement for one of them.

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Section: Discussionsupporting

confidence: 85%

Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia

Selfslagh

Shokur²,

Campos³

et al. 2019

Sci Rep

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“…Amputee patients with a body image disorder often have reduced sensorimotor function, emotional disorders, and compromised social skills ( Ko et al, 2015 ). The present study showed that the occipital lobe, which is involved in the expression of body image disorders, has varying degrees of reduced FC with brain areas that control sensorimotor functions and brain areas that are involved in depression and social emotions.…”

Section: Discussionmentioning

confidence: 99%

Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study

et al. 2021

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The right parietal lobe plays an important role in body image, and disorders of body image emerge after lesions in the parietal lobe or with parietal lobe epilepsy. Body image disorder also often accompanies upper-limb amputation, in which the patient misperceives that their missing limb is still part of their body. Cortical reorganization is known to occur after upper-limb amputation, but it is not clear how widespread and to what degree functional connectivity (FC) is reorganized post-amputation, nor whether such changes might be related to misperceptions of body image. Twenty-four subjects who had a traumatically upper-limb amputees (ULAs) and 24 age-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. Regions of interest (ROIs) in the right superior parietal gyrus (SPG_R) and right inferior parietal lobule (IPL_R) were defined using BrainNet Viewer. We calculated the amplitude of low-frequency fluctuations (ALFF) in ROIs and correlated the ROI mean amplitude of low-frequency fluctuations (mALFF) and mean scores on the phantom limb sensation (PLS) scale and beck depression index (BDI). We also calculated ROIs and whole-brain FC. Compared to the HC group, we observed significantly increased activation (mALFF) in ROIs of the ULA group. Moreover, correlation analyses revealed a significant positive correlation between ROI mALFF and scores on the PLS. There was a significant negative correlation between the SPG_R mALFF and BDI scores. Seed-based, whole-brain FC analysis revealed that FC in the ULA group significantly decreased in many brain regions across the entire brain. The right parietal lobe appears to be involved in some aspect of body awareness and depression in amputation patients. Upper-limb amputation results not only in reorganization in the local brain area formerly representing the missing limb, but also results in more widespread reorganization through FC changes in whole brain.

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“…The discriminating values of amplitude thresholds differ by prostheses and interface locations. Several sensory substitutions have been achieved through vibro-tactile stimulation, which includes the mapping of sensation from the prosthetic hand to the phantom hand for transradial amputees (Antfolk et al, 2013b ; Papetti et al, 2016 ), the increase and decrease of texture roughness feeling on fingers (Asano et al, 2015 ), the sensation through stretching of the skin (Wheeler et al, 2010 ; Motamedi et al, 2017 ), the improvement in grasping force (Chatterjee et al, 2008 ; Cipriani et al, 2008 , 2014 ; Saunders and Vijayakumar, 2011 ; Montagnani et al, 2015 ; Witteveen et al, 2015 ), the evoked sense of proprioception by the vibrations of a tendon (Thyrion and Roll, 2010 ), an object manipulation (Rombokas et al, 2013 ), the sense of embodiment (D'Alonzo et al, 2015 ; Ko et al, 2015 ), and the sensation on the surface of the skin (Kangas et al, 2017 ). The early devices were heavy and energy consuming.…”

Section: Non-invasive Methods Of Sensory Feedbackmentioning

confidence: 99%

Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review

2017

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For those individuals with upper-extremity amputation, a daily normal living activity is no longer possible or it requires additional effort and time. With the aim of restoring their sensory and motor functions, theoretical and technological investigations have been carried out in the field of neuroprosthetic systems. For transmission of sensory feedback, several interfacing modalities including indirect (non-invasive), direct-to-peripheral-nerve (invasive), and cortical stimulation have been applied. Peripheral nerve interfaces demonstrate an edge over the cortical interfaces due to the sensitivity in attaining cortical brain signals. The peripheral nerve interfaces are highly dependent on interface designs and are required to be biocompatible with the nerves to achieve prolonged stability and longevity. Another criterion is the selection of nerves that allows minimal invasiveness and damages as well as high selectivity for a large number of nerve fascicles. In this paper, we review the nerve-machine interface modalities noted above with more focus on peripheral nerve interfaces, which are responsible for provision of sensory feedback. The invasive interfaces for recording and stimulation of electro-neurographic signals include intra-fascicular, regenerative-type interfaces that provide multiple contact channels to a group of axons inside the nerve and the extra-neural-cuff-type interfaces that enable interaction with many axons around the periphery of the nerve. Section Current Prosthetic Technology summarizes the advancements made to date in the field of neuroprosthetics toward the achievement of a bidirectional nerve-machine interface with more focus on sensory feedback. In the Discussion section, the authors propose a hybrid interface technique for achieving better selectivity and long-term stability using the available nerve interfacing techniques.

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Evaluation of physical and emotional responses to vibrotactile stimulation of the forearm in young adults, the elderly, and transradial amputees

Cited by 7 publications

References 34 publications

Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia

Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia

Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study

Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review

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