Evaluation of photon-counting spectral breast tomosynthesis

Dahlman, Nils; Fredenberg, Erik; Åslund, Magnus; Lundqvist, Mats; Diekmann, Felix; Danielsson, Mats

doi:10.1117/12.876874

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…6(e) and is explained by Eq. (14). As a result, the overall optimal techniques for a DE projection of a 4 cm breast with 5 mm lesion, is LE and HE tube potentials of 23 kVp and 47 kVp, respectively, f h of 0.64, and w Sub of 0.22.…”

Section: A2 Effect Of Image Subtractionmentioning

confidence: 98%

“…Recently great effort has been devoted to the research and clinical translation of x-ray contrast-enhanced (CE) breast imaging such as contrast-enhanced digital mammography (CE-DM) [1][2][3][4][5][6][7][8][9][10] and digital breast tomosynthesis (CE-DBT). [10][11][12][13][14][15][16][17][18] CE imaging has the potential to increase the sensitivity and specificity of breast cancer diagnosis because: (a) intravenous injection of iodinated contrast agent enhances the detection and diagnosis of malignant lesions, which often exhibit a signature contrast uptake associated with angiogenesis; [1][2][3][4][5] and (b) the obscuring effect of breast tissue structure can be minimized through image subtraction techniques.…”

Section: Introductionmentioning

confidence: 99%

“…Contrast-enhanced imaging can be implemented with contrast enhancement only or by employing dual energy (DE) 2,4,5,9,[12][13][14][15]17,18 or temporal (TE) 1,3,6,8,11 subtraction. In both subtraction techniques, two images are acquired with the intent of performing simple mathematical operations in order to remove the effect of background tissue.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optimization of contrast‐enhanced breast imaging: Analysis using a cascaded linear system model

Scaduto

Zhao

2017

Medical Physics

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Section: A2 Effect Of Image Subtractionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of contrast‐enhanced breast imaging: Analysis using a cascaded linear system model

Scaduto

Zhao

2017

Medical Physics

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“…filtered backprojection (FBP). Similar models have been employed for planar imaging (Cunningham et al , 2002; Hu and Zhao, 2014; Richard and Siewerdsen, 2008a; Richard et al , 2005) and other forms of 3D imaging, including kV-CBCT (Gang et al , 2011; Gang et al , 2010; Tward and Siewerdsen, 2008; Tward et al , 2008) as well as partially-3D modalities such as digital tomosynthesis (DTS) (Dahlman et al , 2011; Fredenberg et al , 2010; Hu et al , 2008; Hu and Zhao, 2011; Ikejimba et al , 2014; Zhao and Zhao, 2008; Zhao et al , 2009). In short, measurements of 3D resolution and noise may be derived from planar measurements or models of projection space MTF and NPS.…”

Section: Theory/methodsmentioning

confidence: 99%

Physics considerations in MV-CBCT multi-layer imager design

Fueglistaller

Myronakis

et al. 2018

Phys. Med. Biol.

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Megavoltage (MV) cone-beam computed tomography (CBCT) using an electronic portal imaging (EPID) offers advantageous features, including 3D mapping, treatment beam registration, high-z artifact suppression, and direct radiation dose calculation. Adoption has been slowed by image quality limitations and concerns about imaging dose. Developments in imager design, including pixelated scintillators, structured phosphors, inexpensive scintillation materials, and multi-layer imager (MLI) architecture have been explored to improve EPID image quality and reduce imaging dose. The present study employs a hybrid Monte Carlo and linear systems model to determine the effect of detector design elements, such as multi-layer architecture and scintillation materials. We follow metrics of image quality including modulation transfer function (MTF) and noise power spectrum (NPS) from projection images to 3D reconstructions to in-plane slices and apply a task based figure-of-merit, the ideal observer signal-to-noise ratio (d') to determine the effect of detector design on object detectability. Generally, detectability was limited by detector noise performance. Deploying an MLI imager with a single scintillation material for all layers yields improvement in noise performance and d' linear with the number of layers. In general, improving x-ray absorption using thicker scintillators results in improved DQE(0). However, if light yield is low, performance will be affected by electronic noise at relatively high doses, resulting in rapid image quality degradation. Maximizing image quality in a heterogenous MLI detector (i.e. multiple different scintillation materials) is most affected by limiting total noise. However, while a second-order effect, maximizing total spatial resolution of the MLI detector is a balance between the intensity contribution of each layer against its individual MTF. So, while a thinner scintillator may yield a maximal individual-layer MTF, its quantum efficiency will be relatively low in comparison to a thicker scintillator and thus, intensity contribution may be insufficient to noticeably improve the total detector MTF.

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“…Tissue equivalence was achieved by finding the combination of polyethylene and aluminum with the closest fit to the energy-dependent attenuation coefficients for the target material. 12 Published attenuation coefficients for normal and cancerous tissue was used, 11 and cysts were assumed to contain pure water. The lesions were 0, 10, 20, and 30 mm thick, embedded in normal breast tissue, and covered an area of 10 × 10 mm 2 ; see Fig.…”

Section: Phantom Design and Measurementsmentioning

confidence: 99%

Lesion characterization using spectral mammography

et al. 2012

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We present a novel method for characterizing mammographic findings using spectral imaging without the use of contrast agent. Within a statistical framework, suspicious findings are analyzed to determine if they are likely to be benign cystic lesions or malignant tissue. To evaluate the method, we have designed a phantom where combinations of different tissue types are realized by decomposition into the material bases aluminum and polyethylene. The results indicate that the lesion size limit for reliable characterization is below 10 mm diameter, when quantum noise is the only considered source of uncertainty. Furthermore, preliminary results using clinical images are encouraging, but allow no conclusions with significance.

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Evaluation of photon-counting spectral breast tomosynthesis

Cited by 4 publications

References 25 publications

Optimization of contrast‐enhanced breast imaging: Analysis using a cascaded linear system model

Optimization of contrast‐enhanced breast imaging: Analysis using a cascaded linear system model

Physics considerations in MV-CBCT multi-layer imager design

Lesion characterization using spectral mammography

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